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Author Details

Cindy A Hunt
University of California san francisco
1973
126
33
PMIDPaper TitleJournal TitlePublished Year
35867653Utilizing virtual experiments to increase understanding of discrepancies involving in vitro-to-in vivo predictions of hepatic clearance.PLoS One2022
32484845Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms.PLoS Comput Biol2020
32591215Biomedical research models in the science of fracture healing - Pitfalls & promises.Injury2020
32788308A Noncanonical Hippo Pathway Regulates Spindle Disassembly and Cytokinesis During Meiosis in Saccharomyces cerevisiae.Genetics2020
30698817Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange.Toxicol Sci2019
29394245Simulation enabled search for explanatory mechanisms of the fracture healing process.PLoS Comput Biol2018
29434053A Model Mechanism-Based Explanation of an In Vitro-In Vivo Disconnect for Improving Extrapolation and Translation.J Pharmacol Exp Ther2018
26839017A cell-centered, agent-based framework that enables flexible environment granularities.Theor Biol Med Model2016
27984590Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments.PLoS Comput Biol2016
27227433Virtual Experiments Enable Exploring and Challenging Explanatory Mechanisms of Immune-Mediated P450 Down-Regulation.PLoS One2016
24810243Tuneable resolution as a systems biology approach for multi-scale, multi-compartment computational models.Wiley Interdiscip Rev Syst Biol Med2014
25268237In silico, experimental, mechanistic model for extended-release felodipine disposition exhibiting complex absorption and a highly variable food interaction.PLoS One2014
25123169Toward modular biological models: defining analog modules based on referent physiological mechanisms.BMC Syst Biol2014
23737142Agent-based modeling: a systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity.Wiley Interdiscip Rev Syst Biol Med2013
22938185Individualized, discrete event, simulations provide insight into inter- and intra-subject variability of extended-release, drug products.Theor Biol Med Model2012
21490722MDCK cystogenesis driven by cell stabilization within computational analogues.PLoS Comput Biol2011
21768275Enabling clearance predictions to emerge from in silico actions of quasi-autonomous hepatocyte components.Drug Metab Dispos2011
21951817Relational grounding facilitates development of scientifically useful multiscale models.Theor Biol Med Model2011
19864617Mechanistic insight from in silico pharmacokinetic experiments: roles of P-glycoprotein, Cyp3A4 enzymes, and microenvironments.J Pharmacol Exp Ther2010
21129207Cloud computing and validation of expandable in silico livers.BMC Syst Biol2010
20541559Computational experiments reveal plausible mechanisms for changing patterns of hepatic zonation of xenobiotic clearance and hepatotoxicity.J Theor Biol2010
20174606Identifying the rules of engagement enabling leukocyte rolling, activation, and adhesion.PLoS Comput Biol2010
20236957Simulation of lung alveolar epithelial wound healing in vitro.J R Soc Interface2010
20406856Tracing multiscale mechanisms of drug disposition in normal and diseased livers.J Pharmacol Exp Ther2010
18948498Computational strategies unravel and trace how liver disease changes hepatic drug disposition.J Pharmacol Exp Ther2009
20043854A computational approach to resolve cell level contributions to early glandular epithelial cancer progression.BMC Syst Biol2009
19756975At the biological modeling and simulation frontier.Pharm Res2009
19476639Computational investigation of epithelial cell dynamic phenotype in vitro.Theor Biol Med Model2009
19283073A computational approach to understand in vitro alveolar morphogenesis.PLoS One2009
18936110Discovering plausible mechanistic details of hepatic drug interactions.Drug Metab Dispos2009
18044012Modeling and simulation of hepatic drug disposition using a physiologically based, multi-agent in silico liver.Pharm Res2008
21347126A framework and mechanistically focused, in silico method for enabling rational translational research.Summit Transl Bioinform2008
19105850Essential operating principles for tumor spheroid growth.BMC Syst Biol2008
19163953Mechanistic simulations explain paradoxical saquinavir metabolism during in vitro vectorial transport study.Annu Int Conf IEEE Eng Med Biol Soc2008
19163189Using an in silico liver to evaluate a hepatic enzyme induction mechanism.Annu Int Conf IEEE Eng Med Biol Soc2008
19162839In silico simulation of epithelial cell tubulogenesis.Annu Int Conf IEEE Eng Med Biol Soc2008
18612289Dichotomies between computational and mathematical models.Nat Biotechnol2008
18227144Predictions of hepatic disposition properties using a mechanistically realistic, physiologically based model.Drug Metab Dispos2008
18436618In silico methods for unraveling the mechanistic complexities of intestinal absorption: metabolism-efflux transport interactions.Drug Metab Dispos2008
17408504Dynamics of in silico leukocyte rolling, activation, and adhesion.BMC Syst Biol2007
17964677Synthetic nano-LDL with paclitaxel oleate as a targeted drug delivery vehicle for glioblastoma multiforme.J Control Release2007
17548029Challenges and rewards on the road to translational systems biology in acute illness: four case reports from interdisciplinary teams.J Crit Care2007
17703347An in silico transwell device for the study of drug transport and drug-drug interactions.Pharm Res2007
17371750Evidence-based modeling of critical illness: an initial consensus from the Society for Complexity in Acute Illness.J Crit Care2007
17332496Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis.Mol Biol Cell2007
16435171Mechanistic study of the cellular interplay of transport and metabolism using the synthetic modeling method.Pharm Res2006
17369657Simulating in vitro epithelial morphogenesis in multiple environments.Comput Syst Bioinformatics Conf2006
17029556Simulating properties of in vitro epithelial cell morphogenesis.PLoS Comput Biol2006
17051440Physiologically based synthetic models of hepatic disposition.J Pharmacokinet Pharmacodyn2006
16269321Glucose transport to the brain: a systems model.Brain Res Brain Res Rev2005
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Collaborators

Buck Institute for Research on Aging
Co-authored papers 5
Department of Pharmaceutical Sciences, State University of New York
Co-authored papers 4
Cardiovascular Research Institute, University of California san francisco
Co-authored papers 4
University of California san francisco
Co-authored papers 3
University of Vermont
Co-authored papers 2
California Institute of Technology
Co-authored papers 2
University of Pittsburgh
Co-authored papers 2
University of Texas at San Antonio
Co-authored papers 2
University of California San Francisco
Co-authored papers 2
Co-authored papers 2
Center for Health Services Research, Brandenburg Medical School Theodor Fontane
Co-authored papers 2
University of Michigan ann arbor
Co-authored papers 2
University of Pittsburgh
Co-authored papers 2
The University of Sydney
Co-authored papers 1
Co-authored papers 1
University of California at San Francisco
Co-authored papers 1
Universitat Witten/Herdecke Institute for Research in Operative Medicine (IFOM)
Co-authored papers 1
Carnegie Mellon University
Co-authored papers 1
Co-authored papers 1
University of California san francisco
Co-authored papers 1
Co-authored papers 1
Pittsburgh VA Medical Center
Co-authored papers 1
Co-authored papers 1