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Author Details

Lee J Helman
Osteosarcoma Institute
1977
219
75
Nathan Sheffield (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36302175A Phase II Trial of Guadecitabine in Children and Adults with SDH-Deficient GIST, Pheochromocytoma, Paraganglioma, and HLRCC-Associated Renal Cell Carcinoma.Clin Cancer Res2023
36302175A Phase II Trial of Guadecitabine in Children and Adults with SDH-Deficient GIST, Pheochromocytoma, Paraganglioma, and HLRCC-Associated Renal Cell Carcinoma.Clin Cancer Res2023
37398992Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma.Clin Cancer Res2023
37267580The Childhood Cancer Data Initiative: Using the Power of Data to Learn From and Improve Outcomes for Every Child and Young Adult With Pediatric Cancer.J Clin Oncol2023
37398992Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma.Clin Cancer Res2023
37267580The Childhood Cancer Data Initiative: Using the Power of Data to Learn From and Improve Outcomes for Every Child and Young Adult With Pediatric Cancer.J Clin Oncol2023
33063919LRRC15 antibody-drug conjugates show promise as osteosarcoma therapeutics in preclinical studies.Pediatr Blood Cancer2021
33289920SARC025 arms 1 and 2: A phase 1 study of the poly(ADP-ribose) polymerase inhibitor niraparib with temozolomide or irinotecan in patients with advanced Ewing sarcoma.Cancer2021
33063919LRRC15 antibody-drug conjugates show promise as osteosarcoma therapeutics in preclinical studies.Pediatr Blood Cancer2021
34561271Recent Advances in Pediatric Cancer Research.Cancer Res2021
34818481New Horizons in the Treatment of Osteosarcoma.N Engl J Med2021
34818481New Horizons in the Treatment of Osteosarcoma.N Engl J Med2021
34561271Recent Advances in Pediatric Cancer Research.Cancer Res2021
33289920SARC025 arms 1 and 2: A phase 1 study of the poly(ADP-ribose) polymerase inhibitor niraparib with temozolomide or irinotecan in patients with advanced Ewing sarcoma.Cancer2021
32127464CDK9 Blockade Exploits Context-dependent Transcriptional Changes to Improve Activity and Limit Toxicity of Mithramycin for Ewing Sarcoma.Mol Cancer Ther2020
32371575EWS-FLI1-regulated Serine Synthesis and Exogenous Serine are Necessary for Ewing Sarcoma Cellular Proliferation and Tumor Growth.Mol Cancer Ther2020
32127464CDK9 Blockade Exploits Context-dependent Transcriptional Changes to Improve Activity and Limit Toxicity of Mithramycin for Ewing Sarcoma.Mol Cancer Ther2020
32354737Targeting Hippo-Dependent and Hippo-Independent YAP1 Signaling for the Treatment of Childhood Rhabdomyosarcoma.Cancer Res2020
32398945Results of a Randomized, Double-Blinded, Placebo-Controlled, Phase 2.5 Study of Saracatinib (AZD0530), in Patients with Recurrent Osteosarcoma Localized to the Lung.Sarcoma2020
32464274Molecular mechanisms of Guadecitabine induced FGFR4 down regulation in alveolar rhabdomyosarcomas.Neoplasia2020
32354737Targeting Hippo-Dependent and Hippo-Independent YAP1 Signaling for the Treatment of Childhood Rhabdomyosarcoma.Cancer Res2020
32464274Molecular mechanisms of Guadecitabine induced FGFR4 down regulation in alveolar rhabdomyosarcomas.Neoplasia2020
32398945Results of a Randomized, Double-Blinded, Placebo-Controlled, Phase 2.5 Study of Saracatinib (AZD0530), in Patients with Recurrent Osteosarcoma Localized to the Lung.Sarcoma2020
32371575EWS-FLI1-regulated Serine Synthesis and Exogenous Serine are Necessary for Ewing Sarcoma Cellular Proliferation and Tumor Growth.Mol Cancer Ther2020
30808861Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth.Oncogenesis2019
31222885Insights into pediatric rhabdomyosarcoma research: Challenges and goals.Pediatr Blood Cancer2019
30808861Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth.Oncogenesis2019
31431459Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma.Cancer Res2019
31427883Targeting Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors (MPNST) in a Phase II Study of Everolimus in Combination with Bevacizumab (SARC016).Sarcoma2019
31439578A Phase II Trial of Vandetanib in Children and Adults with Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumor.Clin Cancer Res2019
31439578A Phase II Trial of Vandetanib in Children and Adults with Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumor.Clin Cancer Res2019
31431459Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma.Cancer Res2019
31427883Targeting Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors (MPNST) in a Phase II Study of Everolimus in Combination with Bevacizumab (SARC016).Sarcoma2019
31222885Insights into pediatric rhabdomyosarcoma research: Challenges and goals.Pediatr Blood Cancer2019
29334376Positively selected enhancer elements endow osteosarcoma cells with metastatic competence.Nat Med2018
29334376Positively selected enhancer elements endow osteosarcoma cells with metastatic competence.Nat Med2018
29634688Corrigendum: Positively selected enhancer elements endow osteosarcoma cells with metastatic competence.Nat Med2018
29634688Corrigendum: Positively selected enhancer elements endow osteosarcoma cells with metastatic competence.Nat Med2018
28029307Surgical Management of Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Pediatric and Wildtype GIST Clinic.J Clin Oncol2017
28350521Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis).J Clin Oncol2017
28735378A phase I/II trial and pharmacokinetic study of mithramycin in children and adults with refractory Ewing sarcoma and EWS-FLI1 fusion transcript.Cancer Chemother Pharmacol2017
28899971Matrix Screen Identifies Synergistic Combination of PARP Inhibitors and Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors in Ewing Sarcoma.Clin Cancer Res2017
28674120Surveillance Recommendations for Children with Overgrowth Syndromes and Predisposition to Wilms Tumors and Hepatoblastoma.Clin Cancer Res2017
29138631SARC006: Phase II Trial of Chemotherapy in Sporadic and Neurofibromatosis Type 1 Associated Chemotherapy-Naive Malignant Peripheral Nerve Sheath Tumors.Sarcoma2017
28029307Surgical Management of Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Pediatric and Wildtype GIST Clinic.J Clin Oncol2017
27768921A simple and rapid UHPLC-MS/MS method for the quantitation of the dual aurora kinase A/B inhibitor SCH-1473759 in murine plasma.J Pharm Biomed Anal2017
28350521Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis).J Clin Oncol2017
29138631SARC006: Phase II Trial of Chemotherapy in Sporadic and Neurofibromatosis Type 1 Associated Chemotherapy-Naive Malignant Peripheral Nerve Sheath Tumors.Sarcoma2017
28674120Surveillance Recommendations for Children with Overgrowth Syndromes and Predisposition to Wilms Tumors and Hepatoblastoma.Clin Cancer Res2017
28899971Matrix Screen Identifies Synergistic Combination of PARP Inhibitors and Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors in Ewing Sarcoma.Clin Cancer Res2017
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Collaborators

National Cancer Institute, National Institutes of Health
Co-authored papers 33
Center for Cancer Research, National Cancer Institute, National Institutes of Health
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National Cancer Institute, National Institutes of Health
Co-authored papers 21
Center for Cancer Research, National Cancer Institute
Co-authored papers 20
Center for Cancer Research, National Cancer Institute
Co-authored papers 14
Center for Cancer Research, National Cancer Institute
Co-authored papers 12
Georgetown University Medical Center, Georgetown University
Co-authored papers 11
Children's Hospital of Philadelphia.
Co-authored papers 11
National Cancer Institute
Co-authored papers 10
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Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 8
National Cancer Institute, National Institutes of Health
Co-authored papers 8
Stanford University School of Medicine
Co-authored papers 7
University of Texas MD Anderson Cancer Center
Co-authored papers 7
IRCCS Istituto Ortopedico Rizzoli
Co-authored papers 7
Co-authored papers 7
From Foundation Medicine
Co-authored papers 7
The University of Texas Health Science Center at San Antonio
Co-authored papers 6
Clinical Genetics Branch, National Cancer Institute (NCI)
Co-authored papers 6
Center for Cancer Research, National Cancer Institute
Co-authored papers 6
Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 6
National Cancer Institute, National Institutes of Health
Co-authored papers 6
Eunice Kennedy Shriver National Institute of Child Health and Human Development
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St Jude Children's Research Hospital
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Co-authored papers 5
National Cancer Institute, National Institutes of Health
Co-authored papers 5
Co-authored papers 5
National Cancer Institute
Co-authored papers 5
Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 5
National Cancer Institute
Co-authored papers 4