Author details

Full Name

Jerry L Nadler

Affiliation

ORCID

Career Start Year

1983

Papers

253

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36865098	Neutrophil-specific STAT4 deficiency attenuates atherosclerotic burden and improves plaque stability via reduction in neutrophil activation and recruitment into aortas of mice.		2023
37783748	Myeloid cell deficiency of the inflammatory transcription factor Stat4 protects long-term synaptic plasticity from the effects of a high-fat, high-cholesterol diet.		2023
37034649	Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications.	medRxiv	2023
37396582	Neutrophil-specific STAT4 deficiency attenuates atherosclerotic burden and improves plaque stability via reduction in neutrophil activation and recruitment into aortas of mice.		2023
37259182	The severity of SARS-CoV-2 infection in K18-hACE2 mice is attenuated by a novel steroid-derivative in a gender-specific manner.		2023
35399580	Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium.	HGG Adv	2022
35767947	Proinflammatory signaling in islet Î² cells propagates invasion of pathogenic immune cells in autoimmune diabetes.	Cell Reports	2022
35551307	Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.	Nat Genet	2022
36268164	Erratum: Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium.	HGG Adv	2022
35919346	The AAV-PCSK9 murine model of atherosclerosis and metabolic dysfunction.		2022
35136384	Loop-Mediated Isothermal Amplification Detection of SARS-CoV-2 and Myriad Other Applications.	J Biomol Tech	2021
34064822	Regulation of Tissue Inflammation by 12-Lipoxygenases.	Biomolecules	2021
34138758	STAT4 is expressed in neutrophils and promotes antimicrobial immunity.	JCI insight	2021
34507163	Docking and mutagenesis studies lead to improved inhibitor development of ML355 for human platelet 12-lipoxygenase.	Bioorg Med Chem	2021
32093375	Proteomic and Transcriptional Profiles of Human Stem Cell-Derived Î² Cells Following Enteroviral Challenge.	Microorganisms	2020
31442418	Abnormalities in proinsulin processing in islets from individuals with longstanding T1D.	Transl Res	2019
30347209	Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications.	Pharmacology and Therapeutics	2019
30530850	Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes.	Diabetes Care	2019
29463570	Correction: Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease.	J Exp Med	2018
29605541	Activation of the 12/15 lipoxygenase pathway accompanies metabolic decline in db/db pre-diabetic mice.	Prostaglandins and Other Lipid Mediators	2018
28107529	Complement Activation and STAT4 Expression Are Associated with Early Inflammation in Diabetic Wounds.	PLoS ONE	2017
28842399	Inhibition of 12/15-Lipoxygenase Protects Against Î²-Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes.		2017
28877242	Comparative quantitative proteomic analysis of disease stratified laser captured microdissected human islets identifies proteins and pathways potentially related to type 1 diabetes.	PLoS One	2017
28400678	Key Role of STAT4 Deficiency in the Hematopoietic Compartment in Insulin Resistance and Adipose Tissue Inflammation.	Mediators of Inflammation	2017
28609824	12-Lipoxygenase Inhibitor Improves Functions of Cytokine-Treated Human Islets and Type 2 Diabetic Islets.	Journal of Clinical Endocrinology and Metabolism	2017
28566277	Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease.	J Exp Med	2017
29055004	STAT4 Regulates the CD8 Regulatory T Cell/T Follicular Helper Cell Axis and Promotes Atherogenesis in Insulin-Resistant Mice.	Journal of Immunology	2017
29264452	Coxsackievirus-Induced Proteomic Alterations in Primary Human Islets Provide Insights for the Etiology of Diabetes.	J Endocr Soc	2017
27770396	Insulin resistance elicited in postpubertal primate offspring deprived of estrogen in utero.	Endocrine	2016
31741751	Host Factors Alter Effects of Angiopoietin-Like Protein 8 on Glucose Homeostasis in Diabetic Mice.		2016
26757816	Activation of Transmembrane Bile Acid Receptor TGR5 Modulates Pancreatic Islet Î± Cells to Promote Glucose Homeostasis.	J Biol Chem	2016
26875099	Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells.	J Clin Virol	2016
26868492	Lipids and immunoinflammatory pathways of beta cell destruction.	Diabetologia	2016
27207093	Estrogen deprivation in primate pregnancy leads to insulin resistance in offspring.	Journal of Endocrinology	2016
26285907	STAT4 contributes to adipose tissue inflammation and atherosclerosis.	Journal of Endocrinology	2015
25803446	Minireview: 12-Lipoxygenase and Islet Î²-Cell Dysfunction in Diabetes.	Molecular Endocrinology	2015
25417214	Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction.	Diabetologia	2015
25532042	Expression pattern of 12-lipoxygenase in human islets with type 1 diabetes and type 2 diabetes.	Journal of Clinical Endocrinology and Metabolism	2015
25524916	Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.	Diabetes	2015
26555476	Interleukin-12 (IL-12)/STAT4 Axis Is an Important Element for Î²-Cell Dysfunction Induced by Inflammatory Cytokines.	PLoS ONE	2015
26599207	A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS).	PLoS One	2015
26302420	Proteomic Analysis of Disease Stratified Human Pancreas Tissue Indicates Unique Signature of Type 1 Diabetes.	PLoS One	2015
26386214	STAT4 deficiency reduces the development of atherosclerosis in mice.	Atherosclerosis	2015
24955608	Adipose tissue 12/15 lipoxygenase pathway in human obesity and diabetes.	Journal of Clinical Endocrinology and Metabolism	2014
24124113	Insulin sensitivity and insulin clearance are heritable and have strong genetic correlation in Mexican Americans.	Obesity (Silver Spring)	2014
24393039	Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase.	Journal of Medicinal Chemistry	2014
24429578	Association of proinflammatory cytokines and islet resident leucocytes with islet dysfunction in type 2 diabetes.	Diabetologia	2014
24817373	Bariatric surgery decreases monocyte-platelet aggregates in blood: a pilot study.	Obesity Surgery	2014
25071151	12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets.	Molecular and Cellular Biology	2014
23052055	Production and function of IL-12 in islets and beta cells.	Diabetologia	2013