Author details

Full Name

Michael Karin

Affiliation

ORCID

Career Start Year

1979

Papers

679

H Index

239

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37502951	Macrophage Xanthine Oxidoreductase Links LPS Induced Lung Inflammatory Injury to NLRP3 Inflammasome Expression and Mitochondrial Respiration.		2023
35398929	P53 deficiency affects cholesterol esterification to exacerbate hepatocarcinogenesis.	Hepatology	2023
38023993	Cholesterol esterification and p53-mediated tumor suppression.		2023
37889967	IRF1 regulates self-renewal and stress responsiveness to support hematopoietic stem cell maintenance.		2023
37709651	Multifaceted collagen-DDR1 signaling in cancer.		2023
37156770	Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - Î²-catenin cascade to promote liver tumorigenesis.	Nat Commun	2023
37344645	Signalling by senescent melanocytes hyperactivates hair growth.	Nature	2023
37084733	Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness.		2023
37400314	Collagen architecture and signaling orchestrate cancer development.		2023
37328696	Author Correction: A central role for JNK in obesity and insulin resistance.		2023
36882540	Publisher Correction: Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome.	Nature	2023
37126700	Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells.		2023
36945365	Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells.		2023
36747722	IRF1 regulates self-renewal and stress-responsiveness to support hematopoietic stem cell maintenance.		2023
36996941	ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis.		2023
36739208	Oxidized mitochondrial DNA: a protective signal gone awry.		2023
37228755	Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential.		2023
37100955	Apoptotic cell death in disease-Current understanding of the NCCD 2023.	Cell Death Differ	2023
35121655	IKKÎ±-deficient lung adenocarcinomas generate an immunosuppressive microenvironment by overproducing Treg-inducing cytokines.	Proc Natl Acad Sci U S A	2022
36109671	An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory.	Nature Cell Biology	2022
36041455	PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis.	Cell Metab	2022
35835107	Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling.	Immunity	2022
35896521	Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice.	Nat Commun	2022
36001995	Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD.	Semin Liver Dis	2022
35740272	NF-ÎºB: A Double-Edged Sword Controlling Inflammation.	Biomedicines	2022
36198802	Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis.	Nature	2022
36198801	Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome.	Nature	2022
35793657	Diabesity? No worries, FKBP11 to the rescue.		2022
35921818	Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis.		2022
34465885	Regulation of antitumor immunity by inflammation-induced epigenetic alterations.	Cellular and Molecular Immunology	2022
34810213	Concurrent Disruption of the Ras/MAPK and NF-ÎºB Pathways Induces Circadian Deregulation and Hepatocarcinogenesis.	Molecular Cancer Research	2022
35241649	Concerted BAG3 and SIRPÎ± blockade impairs pancreatic tumor growth.	Cell Death Discovery	2022
34887405	CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease.	Nat Commun	2021
33806428	From Liver Fat to Cancer: Perils of the Western Diet.	Cancers	2021
33806040	Honokiol Prevents Non-Alcoholic Steatohepatitis-Induced Liver Cancer via EGFR Degradation through the Glucocorticoid Receptor-MIG6 Axis.	Cancers	2021
34119473	Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice.	Am J Pathol	2021
34115964	Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation.	Immunity	2021
33740421	Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis.	Cancer Cell	2021
33469195	Targeting cancer-promoting inflammation - have anti-inflammatory therapies come of age?	Nature Reviews Clinical Oncology	2021
34215491	The neglected brothers come of age: B cells and cancer.	Seminars in Immunology	2021
33515644	STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway.	Journal of Hepatology	2021
33833060	Soluble Î±-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia.	Proc Natl Acad Sci U S A	2021
33879021	Macropinocytosis: the big drinker behind cancer cell self-consumption.		2021
33602823	Activation of NF-ÎºB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation.	Proc Natl Acad Sci U S A	2021
34403365	Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis.	JCI Insight	2021
34619076	Sweet death: Fructose as a metabolic toxin that targets the gut-liver axis.		2021
31449859	The immunobiology of hepatocellular carcinoma in humans and mice: Basic concepts and therapeutic implications.	Journal of Hepatology	2020
32143413	Immunotherapy, Inflammation and Colorectal Cancer.	Cells	2020
32029622	An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis.	Science	2020
31954207	A dual role for hepatocyte-intrinsic canonical NF-ÎºB signalingÂ inÂ virus control.	J Hepatol	2020