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Author Details

Matthew W Vetting
Albert Einstein College of Medicine
1994
63
30
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
29377793Prediction of enzymatic pathways by integrative pathway mapping.Elife2018
29867142Functional assignment of multiple catabolic pathways for D-apiose.Nat Chem Biol2018
30249705Novel Metabolic Pathways and Regulons for Hexuronate Utilization in Proteobacteria.J Bacteriol2018
28073944A novel bifunctional transcriptional regulator of riboflavin metabolism in Archaea.Nucleic Acids Res2017
26978037Correction to "A General Strategy for the Discovery of Metabolic Pathways: D-Threitol, L-Threitol, and Erythritol Utilization in Mycobacterium smegmatis".J Am Chem Soc2016
27303900Structure of an ABC transporter solute-binding protein specific for the amino sugars glucosamine and galactosamine.Acta Crystallogr F Struct Biol Commun2016
27402745Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars.Proc Natl Acad Sci U S A2016
26750482Purification, crystallization and structural elucidation of D-galactaro-1,4-lactone cycloisomerase from Agrobacterium tumefaciens involved in pectin degradation.Acta Crystallogr F Struct Biol Commun2016
25608448A unique cis-3-hydroxy-l-proline dehydratase in the enolase superfamily.J Am Chem Soc2015
26560079A General Strategy for the Discovery of Metabolic Pathways: d-Threitol, l-Threitol, and Erythritol Utilization in Mycobacterium smegmatis.J Am Chem Soc2015
26472925ATP-binding Cassette (ABC) Transport System Solute-binding Protein-guided Identification of Novel d-Altritol and Galactitol Catabolic Pathways in Agrobacterium tumefaciens C58.J Biol Chem2015
25540822Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes.Biochemistry2015
24450804Galactaro δ-lactone isomerase: lactone isomerization by a member of the amidohydrolase superfamily.Biochemistry2014
24980702Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks.Elife2014
24756107Large-scale determination of sequence, structure, and function relationships in cytosolic glutathione transferases across the biosphere.PLoS Biol2014
24926996Evolution of enzymatic activities in the enolase superfamily: galactarate dehydratase III from Agrobacterium tumefaciens C58.Biochemistry2014
24520058Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant proline betaine.mBio2014
24697546Discovery of function in the enolase superfamily: D-mannonate and d-gluconate dehydratases in the D-mannonate dehydratase subgroup.Biochemistry2014
24401123Prospecting for unannotated enzymes: discovery of a 3',5'-nucleotide bisphosphate phosphatase within the amidohydrolase superfamily.Biochemistry2014
23214453Discovery of an L-fucono-1,5-lactonase from cog3618 of the amidohydrolase superfamily.Biochemistry2013
24056934Discovery of new enzymes and metabolic pathways by using structure and genome context.Nature2013
23968233Structure-guided discovery of new deaminase enzymes.J Am Chem Soc2013
22392983Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily.Proc Natl Acad Sci U S A2012
20937785Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor.Antimicrob Agents Chemother2011
21597116Structure of QnrB1, a plasmid-mediated fluoroquinolone resistance factor.J Biol Chem2011
21393830Pentapeptide-repeat proteins that act as topoisomerase poison resistance factors have a common dimer interface.Acta Crystallogr Sect F Struct Biol Cryst Commun2011
20852636The structure and mechanism of the Mycobacterium tuberculosis cyclodityrosine synthetase.Nat Chem Biol2010
19485344Structure of the ternary complex of phosphomevalonate kinase: the enzyme and its family.Biochemistry2009
19699138Structures and mechanisms of the mycothiol biosynthetic enzymes.Curr Opin Chem Biol2009
19390151Crystallization of a pentapeptide-repeat protein by reductive cyclic pentylation of free amines with glutaraldehyde.Acta Crystallogr D Biol Crystallogr2009
18095712Kinetic and structural analysis of bisubstrate inhibition of the Salmonella enterica aminoglycoside 6'-N-acetyltransferase.Biochemistry2008
19053270The 1.6 A crystal structure of Mycobacterium smegmatis MshC: the penultimate enzyme in the mycothiol biosynthetic pathway.Biochemistry2008
18997321Rv0802c from Mycobacterium tuberculosis: the first structure of a succinyltransferase with the GNAT fold.Acta Crystallogr Sect F Struct Biol Cryst Commun2008
18596200Crystal structure of RimI from Salmonella typhimurium LT2, the GNAT responsible for N(alpha)-acetylation of ribosomal protein S18.Protein Sci2008
18710261Mechanistic and structural analysis of aminoglycoside N-acetyltransferase AAC(6')-Ib and its bifunctional, fluoroquinolone-active AAC(6')-Ib-cr variant.Biochemistry2008
18390549Structural and enzymatic analysis of MshA from Corynebacterium glutamicum: substrate-assisted catalysis.J Biol Chem2008
17516632Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase.Biochemistry2007
17636923New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.J Am Chem Soc2007
17384236Structural characterization of the fusion of two pentapeptide repeat proteins, Np275 and Np276, from Nostoc punctiforme: resurrection of an ancestral protein.Protein Sci2007
17473010Structure of the E. coli bifunctional GlmU acetyltransferase active site with substrates and products.Protein Sci2007
17400916Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate.Protein Sci2007
16388575Pentapeptide repeat proteins.Biochemistry2006
16648861Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid.Nat Struct Mol Biol2006
16326705The substrate-induced conformational change of Mycobacterium tuberculosis mycothiol synthase.J Biol Chem2006
15581578Structure and functions of the GNAT superfamily of acetyltransferases.Arch Biochem Biophys2005
16171781Structure of catechol 1,2-dioxygenase from Pseudomonas arvilla.Biochem Biophys Res Commun2005
15933203A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA.Science2005
15817456A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium.J Biol Chem2005
15838047The active site of O-acetylserine sulfhydrylase is the anchor point for bienzyme complex formation with serine acetyltransferase.J Bacteriol2005
16101286Roles of the equatorial tyrosyl iron ligand of protocatechuate 3,4-dioxygenase in catalysis.Biochemistry2005
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Collaborators

Albert Einstein College of Medicine
Co-authored papers 23
University of Illinois at Urbana-Champaign
Co-authored papers 18
Albert Einstein College of Medicine
Co-authored papers 9
Cardiovascular Research Unit, Newark Beth Israel Medical Center
Co-authored papers 9
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 9
Cue BioPharma Inc.
Co-authored papers 9
ShanghaiTech University, China iHuman Institute
Co-authored papers 7
Carl R. Woese Institute for Genomic Biology , University of Illinois
Co-authored papers 5
New York University Grossman School of Medicine
Co-authored papers 5
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 4
University of California san francisco
Co-authored papers 4
Institute for Genomic Biology, University of Illinois
Co-authored papers 4
University of Illinois
Co-authored papers 3
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 3
Texas A&M University, College Station
Co-authored papers 3
University of California san francisco
Co-authored papers 3
Gwangju Institute of Science and Technology
Co-authored papers 3
University of California san francisco
Co-authored papers 2
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 2
Massachusetts General Hospital
Co-authored papers 2
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 2
Albert Einstein College of Medicine
Co-authored papers 2
University of California at San Diego
Co-authored papers 2
Medical College of Wisconsin
Co-authored papers 2
University of Illinois at Urbana-Champaign
Co-authored papers 2
University of California San Francisco
Co-authored papers 2
Albert Einstein College of Medicine
Co-authored papers 1
The Hospital for Sick Children
Co-authored papers 1
US DOE Joint Genome Institute, Lawrence Berkeley National Laboratory
Co-authored papers 1
Broad Institute of MIT and Harvard
Co-authored papers 1