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Author Details

Alex Look
Dana-Farber Cancer Institute
1975
465
116
PMIDPaper TitleJournal TitlePublished Year
36534523Targeting MET and FGFR in Relapsed or Refractory Acute Myeloid Leukemia: Preclinical and Clinical Findings, and Signal Transduction Correlates.Clin Cancer Res2023
38060444ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factors.Cell Rep2023
37937078Depletion of <i>tet2</i> results in age-dependent changes in DNA methylation and gene expression in a zebrafish model of myelodysplastic syndrome.Front Hematol2023
37153585Towards a better understanding of human iNKT cell subpopulations for improved clinical outcomes.Front Immunol2023
37183825Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state.J Clin Invest2023
37224228Targeted delivery of tumor necrosis factor in combination with CCNU induces a T cell-dependent regression of glioblastoma.Sci Transl Med2023
36916882A lncRNA identifies <i>Irf8</i> enhancer element in negative feedback control of dendritic cell differentiation.Elife2023
36746437Synthetic lethal targeting of TET2-mutant haematopoietic stem and progenitor cells by XPO1 inhibitors.Br J Haematol2023
36909587Genetic Predisposition to Neuroblastoma Results from a Regulatory Polymorphism that Promotes the Adrenergic Cell State.bioRxiv2023
34826338CRISPR/Cas9 editing in conditionally immortalized HoxB8 cells for studying gene regulation in mouse dendritic cells.Eur J Immunol2022
36045346PDGFRβ promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma.Mol Cancer2022
36104101Generation and <i>in vivo</i> validation of an IL-12 fusion protein based on a novel anti-human FAP monoclonal antibody.J Immunother Cancer2022
36037304Multifunctional mRNA-Based CAR T Cells Display Promising Antitumor Activity Against Glioblastoma.Clin Cancer Res2022
36099437p53 Pathway Inactivation Drives SMARCB1-deficient p53-wildtype Epithelioid Sarcoma Onset Indicating Therapeutic Vulnerability Through MDM2 Inhibition.Mol Cancer Ther2022
35931023Retraction Notice to: Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2.Cell2022
35157041Toward Clinical Application of Leukocyte Counts Based on Targeted DNA Methylation Analysis.Clin Chem2022
34772733EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma.Cancer Discov2022
34535013Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL.Blood Adv2022
33972797Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo.Nat Chem Biol2021
33602789GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma.Cancer Res2021
33664368Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL).Sci Rep2021
33553609Targeting ganglioneuromas with mTOR inhibitors.Mol Cell Oncol2021
34956606SARS-CoV-2-host cell surface interactions and potential antiviral therapies.Interface Focus2021
34552066Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.Nat Commun2021
34669465Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma.Sci Adv2021
34638267MEIS2 Is an Adrenergic Core Regulatory Transcription Factor Involved in Early Initiation of TH-MYCN-Driven Neuroblastoma Formation.Cancers (Basel)2021
34233924Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma.Cancer Res2021
34331013Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss.Oncogene2021
32315619Retracted: Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2.Cell2020
32665700Correction: Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma.Leukemia2020
32632335Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X.Nat Genet2020
32572188Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells (HSPCs) with TOP1-targeted drugs and PARP1 inhibitors.Leukemia2020
32651197<i>suz12</i> inactivation in <i>p53</i>- and <i>nf1</i>-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types.Dis Model Mech2020
32728700Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors.J Exp Med2020
30970016Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies.PLoS Genet2019
31819055ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry.Nat Commun2019
30131584Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma.Leukemia2019
30008477The MCL1-specific inhibitor S63845 acts synergistically with venetoclax/ABT-199 to induce apoptosis in T-cell acute lymphoblastic leukemia cells.Leukemia2019
31335977High ENT1 and DCK gene expression levels are a potential biomarker to predict favorable response to nelarabine therapy in T-cell acute lymphoblastic leukemia.Hematol Oncol2019
31305009Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy.Cancer Med2019
30808370Identification of transcription factor binding sites using ATAC-seq.Genome Biol2019
29231124Unraveling Neuroblastoma Pathogenesis with the Zebrafish.Cell Cycle2018
29941549JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.J Exp Med2018
30127528Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry.Nat Genet2018
29510988Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma.Cancer Discov2018
29284669<i>MYC</i> Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification.Cancer Discov2018
27211268KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells.Leukemia2017
28329685Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation.Cell Rep2017
28129858Zebrafish models of leukemia.Methods Cell Biol2017
28295194Anti-leukaemic activity of the TYK2 selective inhibitor NDI-031301 in T-cell acute lymphoblastic leukaemia.Br J Haematol2017
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Collaborators

Donna Neuberg
Co-authored papers 33
Ching-Hon Pui
St. Jude Children's Research Hospital
Co-authored papers 28
John M Maris
Children's Hospital of Philadelphia
Co-authored papers 26
Susan L Cohn
Co-authored papers 23
David M Langenau
MGH Pathology and Harvard Medical School
Co-authored papers 20
Shizhen Zhu
Co-authored papers 16
Charles J Sherr
St. Jude Children's Research Hospital
Co-authored papers 15
Martine F Roussel
St. Jude Children's Research Hospital
Co-authored papers 11
Richard M Stone
Dana Farber Cancer Institute
Co-authored papers 10
Alex Kentsis
Memorial Sloan-Kettering Cancer Center
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Nathanael S Gray
Harvard Medical School
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Amanda L Christie
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Co-authored papers 8
William E Evans
Departments of Oncology. St. Jude Children's Research Hospital
Co-authored papers 8
Mignon L Loh
University of Washington
Co-authored papers 7
Michael D Hogarty
Co-authored papers 7
Daniel J DeAngelo
Dana-Farber Cancer Institute
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Paula K Roberson
and Clinical Center, Central Arkansas Veterans Healthcare System
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Lynda Chin
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Stephen P Hunger
Children's Hospital of Philadelphia
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Kimberly Stegmaier
Dana-Farber Cancer Institute
Co-authored papers 6
Julie M Gastier-Foster
Baylor College of Medicine
Co-authored papers 6
Charles G Mullighan
St Jude Children's Research Hospital
Co-authored papers 5
Steven M Kornblau
The University of Texas MD Anderson Cancer Center
Co-authored papers 5
David M Weinstock
Merck & Co.
Co-authored papers 5
Yu Liu
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital
Co-authored papers 5
Alexei Protopopov
The University of MD Anderson Cancer Center
Co-authored papers 5
Jinghui Zhang
Changhai Hospital, Second Military Medical University
Co-authored papers 5
Charles Lee
Co-authored papers 5
Matthew Meyerson
Broad Institute
Co-authored papers 4
Jonathan R Mathias
Colleges of Life and Environmental Sciences, University of Birmingham
Co-authored papers 4
Release 1.2