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Author Details

Hermann Bihler
1995
25
20
PMIDPaper TitleJournal TitlePublished Year
34272367A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion.Nature Communications2021
32332735Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope.Nat Commun2020
30836009Nonsense-mediated RNA Decay Pathway Inhibition Restores Expression and Function of W1282X CFTR.American Journal of Respiratory Cell and Molecular Biology2019
29934203CFTR modulator theratyping: Current status, gaps and future directions.J Cyst Fibros2019
30563749Isogenic cell models of cystic fibrosis-causing variants in natively expressing pulmonary epithelial cells.J Cyst Fibros2019
29318594Partial rescue of F508del-cystic fibrosis transmembrane conductance regulator channel gating with modest improvement of protein processing, but not stability, by a dual-acting small molecule.British Journal of Pharmacology2018
30069044A revised airway epithelial hierarchy includes CFTR-expressing ionocytes.Nature2018
28376702High-Throughput Screening for Readthrough Modulators of CFTR PTC Mutations.SLAS Technology2017
27320041Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells.Cell Stem Cell2016
22902621A novel approach to recovery of function of mutant proteins by slowing down translation.Journal of Biological Chemistry2012
22722932Conformational changes relevant to channel activity and folding within the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator.J Biol Chem2012
20976528Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening.J Comput Aided Mol Des2010
18421473Functional consequences of leucine and tyrosine mutations in the dual pore motifs of the yeast K(+) channel, Tok1p.Pflugers Archiv European Journal of Physiology2008
16113216TPK1 is a vacuolar ion channel different from the slow-vacuolar cation channel.Plant Physiology2005
16133265In the yeast potassium channel, Tok1p, the external ring of aspartate residues modulates both gating and conductance.Pflugers Archiv European Journal of Physiology2005
15216418Chloride channel function in the yeast TRK-potassium transporters.Journal of Membrane Biology2004
14645064Electrophysiological analysis of the yeast V-type proton pump: variable coupling ratio and proton shunt.Biophysical Journal2003
12535075Characterization of potassium transport in wild-type and isogenic yeast strains carrying all combinations of trk1, trk2 and tok1 null mutations.Molecular Microbiology2003
11779561Low-affinity potassium uptake by Saccharomyces cerevisiae is mediated by NSC1, a calcium-blocked non-specific cation channel.2002
10218594The presumed potassium carrier Trk2p in Saccharomyces cerevisiae determines an H+-dependent, K+-independent current.FEBS Letters1999
9710251NSC1: a novel high-current inward rectifier for cations in the plasma membrane of Saccharomyces cerevisiae.FEBS Letters1998
9799419Electrophysiology in the eukaryotic model cell Saccharomyces cerevisiae.Pflugers Archiv European Journal of Physiology1998
9516239Physiological characterization of the yeast plasma membrane outward rectifying K+ channel, DUK1 (TOK1), in situ.Journal of Membrane Biology1998
9251791The inner membrane barrier of lipid membranes experienced by the valinomycin/Rb+ complex: charge pulse experiments at high membrane voltages.Biophysical Journal1997
7756564Application of a fast charge-pulse technique to study the effect of the dipolar substance 2,4-dichlorophenoxyacetic acid on the kinetics of valinomycin mediated K(+)-transport across monoolein membranes.Biophysical Chemistry1995
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Cystic Fibrosis Foundation
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Centre Hospitalier Universitaire
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Harvard University
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Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
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Johns Hopkins University School of Medicine
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Broad Institute of MIT and Harvard
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Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science
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