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Author Details

David Eliezer
Brain and Mind Research Institute
1993
119
54
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37645938Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains.bioRxiv2024
36711595Structure and DNA bridging activity of the essential Rec114â⿬"Mei4 trimer interface.bioRxiv2023
37741841Alpha synuclein modulates mitochondrial Ca<sup>2+</sup> uptake from ER during cell stimulation and under stress conditions.NPJ Parkinsons Dis2023
37873141Phosphoglycerate kinase is a central leverage point in Parkinson's Disease driven neuronal metabolic deficits.bioRxiv2023
35777466Membrane Binding Induces Distinct Structural Signatures in the Mouse Complexin-1C-Terminal Domain.J Mol Biol2023
37023263Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by <sup>19</sup>F NMR and Cryo-EM.J Am Chem Soc2023
37442580Structure and DNA-bridging activity of the essential Rec114-Mei4 trimer interface.Genes Dev2023
37163091Alpha Synuclein Modulates Mitochondrial Ca <sup>2+</sup> Uptake from ER During Cell Stimulation and Under Stress Conditions.bioRxiv2023
34838590Post-translational modifications within tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation.J Biol Chem2022
35809645Molecular and functional interactions of alpha-synuclein with Rab3a.J Biol Chem2022
35417693Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins.Cell Rep2022
36551244The Role of Membrane Affinity and Binding Modes in Alpha-Synuclein Regulation of Vesicle Release and Trafficking.Biomolecules2022
36358923Proline-Rich Region II (PRR2) Plays an Important Role in Tau-Glycan Interaction: An NMR Study.Biomolecules2022
35287864Homogalacturonan from squash: Characterization and tau-binding pattern of a sulfated derivative.Carbohydr Polym2022
35013160Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease.Nat Commun2022
34928512The dopamine receptor agonist apomorphine stabilizes neurotoxic α-synuclein oligomers.FEBS Lett2022
33274519Chemoenzymatic Semi-synthesis Enables Efficient Production of Isotopically Labeled α-Synuclein with Site-Specific Tyrosine Phosphorylation.Chembiochem2021
33662414Fisetin inhibits tau aggregation by interacting with the protein and preventing the formation of β-strands.Int J Biol Macromol2021
32514183Use of paramagnetic [19]F NMR to monitor domain movement in a glutamate transporter homolog.Nat Chem Biol2020
32696379Interactions of IDPs with Membranes Using Dark-State Exchange NMR Spectroscopy.Methods Mol Biol2020
32696377Probing IDP Interactions with Membranes by Fluorescence Spectroscopy.Methods Mol Biol2020
32778793Tau induces PSD95-neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration.Nat Neurosci2020
32341125Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau.J Biol Chem2020
32143619Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts.BMC Complement Med Ther2020
30700558Intrinsically disordered proteins in synaptic vesicle trafficking and release.J Biol Chem2019
31799930Exchange of water for sterol underlies sterol egress from a StARkin domain.Elife2019
31263746Regulation of exocytosis and mitochondrial relocalization by Alpha-synuclein in a mammalian cell model.NPJ Parkinsons Dis2019
31096049Membrane interactions of intrinsically disordered proteins: The example of alpha-synuclein.Biochim Biophys Acta Proteins Proteom2019
30771177Probing Structural Changes in Alpha-Synuclein by Nuclear Magnetic Resonance Spectroscopy.Methods Mol Biol2019
30352158Role of Parkinson's Disease-Linked Mutations and N-Terminal Acetylation on the Oligomerization of α-Synuclein Induced by 3,4-Dihydroxyphenylacetaldehyde.ACS Chem Neurosci2019
29463678Structural basis of sterol binding and transport by a yeast StARkin domain.J Biol Chem2018
29991141Parkinson's Disease and Melanoma: Co-Occurrence and Mechanisms.J Parkinsons Dis2018
30249394Exploring the role of methionine residues on the oligomerization and neurotoxic properties of DOPAL-modified α-synuclein.Biochem Biophys Res Commun2018
29925018A Protofilament-Protofilament Interface in the Structure of Mouse α-Synuclein Fibrils.Biophys J2018
30471689Spectroscopic Characterization of Structure-Function Relationships in the Intrinsically Disordered Protein Complexin.Methods Enzymol2018
29663556Structure and dynamics of the extended-helix state of alpha-synuclein: Intrinsic lability of the linker region.Protein Sci2018
27810285Phosphorylation regulates the secondary structure and function of dentin phosphoprotein peptides.Bone2017
28297651Glycan Determinants of Heparin-Tau Interaction.Biophys J2017
29162800Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes.Nat Commun2017
29160204Proteins acting out of (dis)order.Elife2017
28596722Unique Structural Features of Membrane-Bound C-Terminal Domain Motifs Modulate Complexin Inhibitory Function.Front Mol Neurosci2017
28603484Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate Complexins.Front Mol Neurosci2017
27432996Conformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles.J Gen Physiol2016
26601760The C-terminal α-helices of mammalian Hsc70 play a critical role in the stabilization of α-synuclein binding and inhibition of aggregation.Int J Biol Macromol2016
27356045Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations.ACS Chem Biol2016
27488222Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril.Sci Rep2016
25449909Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils.Neurobiol Dis2015
26381411Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL).J Biol Chem2015
26168008STARD4 Membrane Interactions and Sterol Binding.Biochemistry2015
24412932c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.Hum Mol Genet2014
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Collaborators

Keith O Hodgson
Stanford University
Co-authored papers 6
Eliezer Masliah
National Institute On Aging
Co-authored papers 4
Hiro Tsuruta
Stanford University
Co-authored papers 3
Bing Shan
Co-authored papers 3
Fuming Zhang
Rensselaer Polytechnic Institute
Co-authored papers 3
Robert J Linhardt
Rensselaer Polytechnic Institute
Co-authored papers 3
Harel Weinstein
Institute for Computational Biomedicine
Co-authored papers 3
Shixin Liu
The Rockefeller University
Co-authored papers 2
Aaron D Gitler
Stanford University School of Medicine
Co-authored papers 2
Vladimir N Uversky
Morsani College of Medicine, University of South Florida
Co-authored papers 2
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University of California San Francisco
Co-authored papers 1
Alexander P Golovanov
The University of Manchester
Co-authored papers 1
David A Case
Rutgers University
Co-authored papers 1
Oliver F Lange
Center for Integrated Protein Science, Technische Universitat Munchen
Co-authored papers 1
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Leicester Institute of Structural and Chemical Biology, University of Leicester
Co-authored papers 1
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University of Texas Southwestern Medical Center
Co-authored papers 1
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The University of Sheffield
Co-authored papers 1
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Institute of Systems, The University of Liverpool
Co-authored papers 1
Igor L Barsukov
Institute of Integrative Biology, University of Liverpool
Co-authored papers 1
David E Shaw
Columbia University
Co-authored papers 1
Ad Bax
National Institutes of Health
Co-authored papers 1
Patrick C A van der Wel
Zernike Institute for Advanced Materials, University of Groningen
Co-authored papers 1
David Middleton
Co-authored papers 1
Ioannis Vakonakis
University of Oxford
Co-authored papers 1
Thomas A Frenkiel
The Medical Research Council Biomedical NMR Centre, The Francis Crick Institute
Co-authored papers 1
Ernest D Laue
University of Cambridge
Co-authored papers 1
Gordon S Rule
Carnegie Mellon University
Co-authored papers 1
Stephen Matthews
Imperial College London
Co-authored papers 1
Chien Ho
Carnegie Mellon University
Co-authored papers 1
Oliver Hantschel
Institute of Physiological Chemistry, University of Marburg 35032 Marburg Germany .
Co-authored papers 1
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