Author details

Full Name

Michael T McManus

Affiliation

ORCID

Career Start Year

1997

Papers

121

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36945732	Dynamics of Chromatin Accessibility During Hematopoietic Stem Cell Differentiation Into Progressively Lineage-Committed Progeny.		2023
37033725	SARS-CoV-2 <i>ORF3A</i> interacts with the Clic-like chloride channel-1 (<i>CLCC1</i>) and triggers an unfolded protein response.	PeerJ	2023
35273077	Nucleolar-based repression is essential for embryonic two-cell stage exit.	Genes and Development	2022
34301766	<i>miR-200</i> deficiency promotes lung cancer metastasis by activating Notch signaling in cancer-associated fibroblasts.	Genes Dev	2021
33824487	Examining the evidence for extracellular RNA function in mammals.	Nature Reviews Genetics	2021
33264610	miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling.	Cell Reports	2020
32041354	Host-Receptor Post-Translational Modifications Refine Staphylococcal Leukocidin Cytotoxicity.	Toxins	2020
33378675	High-Throughput CRISPR Screening Identifies Genes Involved in Macrophage Viability and Inflammatory Pathways.	Cell Reports	2020
32668250	Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo.	Cell Rep	2020
32615086	CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.	Cell	2020
31319050	Thermoregulation via Temperature-Dependent PGD<sub>2</sub> Production in Mouse Preoptic Area.	Neuron	2019
30970263	High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions.	Cell Reports	2019
31435015	BCAA catabolism in brown fat controls energy homeostasis through SLC25A44.	Nature	2019
31433990	miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival.	Cell Rep	2019
31433982	Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons.	Cell Rep	2019
30727954	Tracing cellular heterogeneity in pooled genetic screens via multi-level barcoding.	BMC Genomics	2019
29632189	Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation.	Proc Natl Acad Sci U S A	2018
30404006	Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2.	Cell Rep	2018
30267595	miR-205 Regulates Basal Cell Identity and Stem Cell Regenerative Potential During Mammary Reconstitution.	Stem Cells	2018
30059978	A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission.	Endocrinology	2018
30532236	Far away from the lamppost.	PLoS Biol	2018
30177744	Publisher Correction: Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton-Valentine leukocidin.	Nature Microbiology	2018
29717003	Corrigendum: A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity.	Genome Res	2018
29567993	Unexplored therapeutic opportunities in the human genome.	Nat Rev Drug Discov	2018
29351846	Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals.	Mol Cell	2018
29472638	Unexplored therapeutic opportunities in the human genome.	Nat Rev Drug Discov	2018
29334369	Dual gene activation and knockout screen reveals directional dependencies in genetic networks.	Nat Biotechnol	2018
29736038	Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton-Valentine leukocidin.	Nature Microbiology	2018
29499153	The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational Output.	Cell Stem Cell	2018
28103525	MicroRNAs in ectodermal appendages.	Current Opinion in Genetics and Development	2017
28511845	miR-205 is a critical regulator of lacrimal gland development.	Developmental Biology	2017
28576768	Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland.	Development	2017
29051223	CRISPR/Cas-based screening of long non-coding RNAs (lncRNAs) in macrophages with an NF-ÎºB reporter.	Journal of Biological Chemistry	2017
29088702	Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition.	Nature	2017
28246293	A Whole-Genome RNA Interference Screen Reveals a Role for <i>Spry2</i> in Insulin Transcription and the Unfolded Protein Response.	Diabetes	2017
27831498	A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity.	Genome Res	2017
27775705	PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression.	Nat Med	2016
26850657	MicroRNAs 24 and 27 Suppress Allergic Inflammation and Target a Network of Regulators of T Helper 2 Cell-Associated Cytokine Production.	Immunity	2016
25131933	A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver.	Hepatology	2015
25693563	Integrative analysis of 111 reference human epigenomes.	Nature	2015
25690954	Epigenetic and transcriptional determinants of the human breast.	Nat Commun	2015
26320939	Biogenesis, delivery, and function of extracellular RNA.	J Extracell Vesicles	2015
26270036	Identification of MiR-205 As a MicroRNA That Is Highly Expressed in Medullary Thymic Epithelial Cells.	PLoS ONE	2015
26000843	Choosing the Right Tool for the Job: RNAi, TALEN, or CRISPR.	Molecular Cell	2015
25001157	Discovering the complexity of the metazoan transcriptome.		2014
25036638	Systematic identification of barriers to human iPSC generation.	Cell	2014
24633241	Massively parallel functional annotation of 3' untranslated regions.	Nature Biotechnology	2014
24807418	A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation.	Nat Commun	2014
24608041	Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210.	Nat Immunol	2014
24788257	Dicer regulates differentiation and viability during mouse pancreatic cancer initiation.	PLoS ONE	2014