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Author Details

Betty Chang
1998
65
43
PMIDPaper TitleJournal TitlePublished Year
35259016Small molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration.Proc Natl Acad Sci U S A2022
35874767Targeting Multiple End Organs in Lupus and Other Systemic Rheumatic Diseases by Inhibiting Bruton's Tyrosine Kinase.Frontiers in Immunology2022
33454843Cannabinoid type 1 receptors in A2a neurons contribute to cocaine-environment association.Psychopharmacology2021
33540074Acute and late administration of colony stimulating factor 1 attenuates chronic cognitive impairment following mild traumatic brain injury in mice.Brain, Behavior, and Immunity2021
33519915LncRNA H19 Suppresses Osteosarcomagenesis by Regulating snoRNAs and DNA Repair Protein Complexes.Frontiers in Genetics2020
32131714Effects of ibrutinib on in vitro platelet aggregation in blood samples from healthy donors and donors with platelet dysfunction.Hematology2020
30517869Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming.Cell Rep2018
28592889Extended follow-up and impact of high-risk prognostic factors from the phase 3 RESONATE study in patients with previously treated CLL/SLL.Leukemia2018
30030853The effect of Bruton's tyrosine kinase (BTK) inhibitors on collagen-induced platelet aggregation, BTK, and tyrosine kinase expressed in hepatocellular carcinoma (TEC).European Journal of Haematology2018
28031181Ibrutinib inhibits pre-BCR B-cell acute lymphoblastic leukemia progression by targeting BTK and BLK.Blood2017
28428442Combination of Ibrutinib and ABT-199 in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma.Molecular Cancer Therapeutics2017
28363982Deficiency in Neuronal TGF-β Signaling Leads to Nigrostriatal Degeneration and Activation of TGF-β Signaling Protects against MPTP Neurotoxicity in Mice.J Neurosci2017
27904766The role of PIM1 in the ibrutinib-resistant ABC subtype of diffuse large B-cell lymphoma.American Journal of Cancer Research (discontinued)2016
26954547Hematopoietic Reprogramming In Vitro Informs In Vivo Identification of Hemogenic Precursors to Definitive Hematopoietic Stem Cells.Developmental Cell2016
26715645Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer.Cancer Discovery2016
26660519Disruption of in vivo Chronic Lymphocytic Leukemia Tumor-Microenvironment Interactions by Ibrutinib--Findings from an Investigator-Initiated Phase II Study.Clin Cancer Res2016
26582643BTK inhibition results in impaired CXCR4 chemokine receptor surface expression, signaling and function in chronic lymphocytic leukemia.Leukemia2016
27678331Ibrutinib Inhibits ERBB Receptor Tyrosine Kinases and HER2-Amplified Breast Cancer Cell Growth.Molecular Cancer Therapeutics2016
26193343Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma.Nat Med2015
25860607Modeling familial cancer with induced pluripotent stem cells.Cell2015
25730880Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK.Proceedings of the National Academy of Sciences of the United States of America2015
26095607Tbx3 Controls Dppa3 Levels and Exit from Pluripotency toward Mesoderm.Stem Cell Reports2015
26529251Pharmacoproteomics identifies combinatorial therapy targets for diffuse large B cell lymphoma.Journal of Clinical Investigation2015
26487364Synergistic Effect of Sorafenib and Radiation on Human Oral Carcinoma in vivo.Scientific Reports2015
25082755Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma.Cancer Discov2014
24316417The orally available Btk inhibitor ibrutinib (PCI-32765) protects against osteoclast-mediated bone loss.2014
24311722Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL).Blood2014
24332241Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: an open-label, multicentre, phase 1b/2 trial.Lancet Oncology, The2014
24869598Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib.N Engl J Med2014
24721226Bruton's tyrosine kinase inhibitors for the treatment of rheumatoid arthritis.Drug Discovery Today2014
25189909Synergistic effect of sorafenib with ionizing radiation on human oral cancer cells.In Vivo2014
24659631Ibrutinib inhibits BCR and NF-κB signaling and reduces tumor proliferation in tissue-resident cells of patients with CLL.Blood2014
23045577Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies.Journal of Clinical Oncology2013
23770078Induction of a hemogenic program in mouse fibroblasts.Cell Stem Cell2013
23940282Egress of CD19(+)CD5(+) cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor ibrutinib in mantle cell lymphoma patients.Blood2013
23886836Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes.Blood2013
23782158Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia.New England Journal of Medicine2013
23782157Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma.N Engl J Med2013
23136880Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus.2012
22689860Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma.Blood2012
22871175Emergency department diagnosis of upper extremity deep venous thrombosis using bedside ultrasonography.Critical Ultrasound Journal2012
22279054The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia.Blood2012
22862944Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling.Cell Stem Cell2012
21752263The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells.2011
21477851Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network.Cell2011
20535210Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome.Nature2010
19609559Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen.Journal of Cancer Research and Clinical Oncology2010
20615965The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy.Proceedings of the National Academy of Sciences of the United States of America2010
20145120R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer.Cancer Research2010
19596999JAK3 inhibition significantly attenuates psoriasiform skin inflammation in CD18 mutant PL/J mice.Journal of Immunology2009
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Icahn School of Medicine at Mount Sinai
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Stanford University
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