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Author Details

Nicolas Rapin
Rigshospitalet, University of Copenhagen
2006
43
26
PMIDPaper TitleJournal TitlePublished Year
35545054PTBP1 promotes hematopoietic stem cell maintenance and red blood cell development by ensuring sufficient availability of ribosomal constituents.Cell Rep2022
34099695Quantitative single-cell proteomics as a tool to characterize cellular hierarchies.Nat Commun2021
30635567The splicing factor RBM25 controls MYC activity in acute myeloid leukemia.Nat Commun2019
31775043ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination.Cell Rep2019
31623675Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes.Clin Epigenetics2019
31309149Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML.Sci Adv2019
30395307BloodSpot: a database of healthy and malignant haematopoiesis updated with purified and single cell mRNA sequencing profiles.Nucleic Acids Res2019
29695774Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies.Nat Commun2018
30021172Differences in Cell Cycle Status Underlie Transcriptional Heterogeneity in the HSC Compartment.Cell Rep2018
30015632Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates.J Clin Invest2018
29986855Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin.Blood Adv2018
29847803Enhancer and Transcription Factor Dynamics during Myeloid Differentiation Reveal an Early Differentiation Block in Cebpa null Progenitors.Cell Rep2018
28263309EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas.Nat Med2017
28126036Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types.Genome Biol2017
27095194Peak-valley-peak pattern of histone modifications delineates active regulatory elements and their directionality.Nucleic Acids Res2016
26507857BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis.Nucleic Acids Res2016
27755585MicroRNA-941 Expression in Polymorphonuclear Granulocytes Is Not Related to Granulomatosis with Polyangiitis.PLoS One2016
28004750SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization.Nat Commun2016
25349154TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia.Leukemia2015
26385962ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation.Genes Dev2015
25886910Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis.Genes Dev2015
25670329Cellular origin of prognostic chromosomal aberrations in AML patients.Leukemia2015
24415956C/EBPα is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitors.PLoS Genet2014
24932908Oncogenic fusion proteins expressed in immature hematopoietic cells fail to recapitulate the transcriptional changes observed in human AML.Oncogenesis2014
24670763An atlas of active enhancers across human cell types and tissues.Nature2014
24367003Initiation of MLL-rearranged AML is dependent on C/EBPα.J Exp Med2014
24363398Comparing cancer vs normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients.Blood2014
23143109HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis.Nucleic Acids Res2013
23831605Lack of the p42 form of C/EBPα leads to spontaneous immortalization and lineage infidelity of committed myeloid progenitors.Exp Hematol2013
23403033Temporal mapping of CEBPA and CEBPB binding during liver regeneration reveals dynamic occupancy and specific regulatory codes for homeostatic and cell cycle gene batteries.Genome Res2013
22745298HemaExplorer: a Web server for easy and fast visualization of gene expression in normal and malignant hematopoiesis.Blood2012
23058041Intestinal transporters for endogenic and pharmaceutical organic anions: the challenges of deriving in-vitro kinetic parameters for the prediction of clinically relevant drug-drug interactions.J Pharm Pharmacol2012
21244330CTLs' repertoire shaping in the thymus: a Monte Carlo simulation.Autoimmunity2011
21888970Simulating kinetic parameters in transporter mediated permeability across Caco-2 cells. A case study of estrone-3-sulfate.Eur J Pharm Sci2011
21685045Immune system simulation online.Bioinformatics2011
21112392Gaboxadol has affinity for the proton-coupled amino acid transporter 1, SLC36A1 (hPAT1)--A modelling approach to determine IC(50) values of the three ionic species of gaboxadol.Eur J Pharm Sci2011
21244341Bistability in autoimmune diseases.Autoimmunity2011
20419125Computational immunology meets bioinformatics: the use of prediction tools for molecular binding in the simulation of the immune system.PLoS One2010
20439274ImmunoGrid: towards agent-based simulations of the human immune system at a natural scale.Philos Trans A Math Phys Eng Sci2010
20143317The MHC motif viewer: a visualization tool for MHC binding motifs.Curr Protoc Immunol2010
19383844ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization.Brief Bioinform2009
18766337MHC motif viewer.Immunogenetics2008
19669470Modelling the human immune system by combining bioinformatics and systems biology approaches.J Biol Phys2006
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Collaborators

Center for Genomic Medicine, Rigshospitalet Copenhagen University Hospital
Co-authored papers 15
Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
Co-authored papers 3
LEO Pharma
Co-authored papers 3
Technical University of Denmark
Co-authored papers 3
Co-authored papers 2
University of Copenhagen
Co-authored papers 2
The Netherlands Cancer Institute
Co-authored papers 2
The Institute of Cancer Research
Co-authored papers 2
University of Copenhagen
Co-authored papers 2
University of Copenhagen
Co-authored papers 2
RIKEN Center for Integrative Medical Sciences
Co-authored papers 2
Rigshospitalet, University of Copenhagen
Co-authored papers 2
Hospital of Obstetrics and Gynecology, Fudan University
Co-authored papers 2
University of Copenhagen
Co-authored papers 2
Institute of Structural and Molecular Biology, University of London
Co-authored papers 2
Statens Serum Institut
Co-authored papers 2
International Institute of Molecular and Cell Biology in Warsaw
Co-authored papers 1
German Center for Neurodegenerative Diseases (DZNE).
Co-authored papers 1
Co-authored papers 1
Karolinska Institute
Co-authored papers 1
RIKEN Center for Integrative Medical Sciences
Co-authored papers 1
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 1
RIKEN Center for Integrative Medical Sciences
Co-authored papers 1
Pediatric Cancer Center Barcelona, Hospital Sant Joan de Deu
Co-authored papers 1
Vanda Pharmaceuticals Inc.
Co-authored papers 1
Leibniz Institute for Immunotherapy, c/o University Hospital Regensburg
Co-authored papers 1
RIKEN Center for Integrative Medical Sciences
Co-authored papers 1
VILLUM Center for Bioanalytical Sciences, University of Southern Denmark
Co-authored papers 1
RIKEN Center for Life Science Technologies
Co-authored papers 1
Mater Research Institute-UQ, Translational Research Institute
Co-authored papers 1