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Author Details

George D Yancopoulos
1984
486
182
PMIDPaper TitleJournal TitlePublished Year
37523551Activin E-ACVR1C cross talk controls energy storage via suppression of adipose lipolysis in mice.2023
37992152Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency.2023
38091405A therapeutic strategy to target distinct sources of IgE and durably reverse allergy.2023
37792612Sarilumab for Relapse of Polymyalgia Rheumatica during Glucocorticoid Taper.N Engl J Med2023
37613478Structural Analysis of Cancer-relevant TCR-CD3 and Peptide-MHC Complexes by CryoEM.2023
37770652Garetosmab in fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial.Nat Med2023
37410813A cellular and molecular spatial atlas of dystrophic muscle.2023
37272521Dupilumab for COPD with Type 2 Inflammation Indicated by Eosinophil Counts.2023
37142763Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials.Nat Med2023
36494054Association of complement pathways with COVID-19 severity and outcomes.Microbes Infect2023
36481478IL-4 and IL-13, not eosinophils, drive type 2 airway inflammation, remodeling and lung function decline.2023
36630481Blocking common γ chain cytokine signaling ameliorates T cell-mediated pathogenesis in disease models.Sci Transl Med2023
36930708Structural insights into the assembly of gp130 family cytokine signaling complexes.2023
37100770Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM.2023
35139273Survival with Cemiplimab in Recurrent Cervical Cancer.N Engl J Med2022
35969402Virologic Efficacy of Casirivimab and Imdevimab COVID-19 Antibody Combination in Outpatients With SARS-CoV-2 Infection: A Phase 2 Dose-Ranging Randomized Clinical Trial.JAMA Netw Open2022
35895508Casirivimab and Imdevimab for the Treatment of Hospitalized Patients With COVID-19.J Infect Dis2022
36008722Cemiplimab plus chemotherapy versus chemotherapy alone in non-small cell lung cancer: a randomized, controlled, double-blind phase 3 trial.Nature Medicine2022
36001963Disruption of nuclear envelope integrity as a possible initiating event in tauopathies.Cell Reports2022
35999217Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes.Nat Commun2022
35939579Germline Mutations in <i>CIDEB</i> and Protection against Liver Disease.N Engl J Med2022
35934082REGN1908/1909 prevented cat allergen-induced early asthmatic responses in an environmental exposure unit.Journal of Allergy and Clinical Immunology2022
35788416Repeat subcutaneous administration of casirivimab and imdevimab in adults is well-tolerated and prevents the occurrence of COVID-19.Int J Infect Dis2022
36255239Casirivimab and Imdevimab Treatment Reduces Viral Load and Improves Clinical Outcomes in Seropositive Hospitalized COVID-19 Patients with Nonneutralizing or Borderline Neutralizing Antibodies.mBio2022
36546624Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis.N Engl J Med2022
34126156Novel antibody cocktail targeting Bet v 1 rapidly and sustainably treats birch allergy symptoms in a phase 1 study.Journal of Allergy and Clinical Immunology2022
34126155Targeting immunodominant Bet v 1 epitopes with monoclonal antibodies prevents the birch allergic response.Journal of Allergy and Clinical Immunology2022
33507266Human Monoclonal Antibody Cocktail for the Treatment or Prophylaxis of Middle East Respiratory Syndrome Coronavirus.J Infect Dis2022
35219277Efficacy and Safety of Sarilumab in Hospitalized Patients With Coronavirus Disease 2019: A Randomized Clinical Trial.Clin Infect Dis2022
35029629Effect of Subcutaneous Casirivimab and Imdevimab Antibody Combination vs Placebo on Development of Symptomatic COVID-19 in Early Asymptomatic SARS-CoV-2 Infection: A Randomized Clinical Trial.JAMA2022
34971385Compassionate Use of REGEN-COV® in Patients With Coronavirus Disease 2019 (COVID-19) and Immunodeficiency-Associated Antibody Disorders.Clinical Infectious Diseases2022
34587383REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19.N Engl J Med2021
33581821Cemiplimab monotherapy for first-line treatment of advanced non-small-cell lung cancer with PD-L1 of at least 50%: a multicentre, open-label, global, phase 3, randomised, controlled trial.Lancet, The2021
34161776The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies.Cell2021
34159343Subcutaneous REGEN-COV Antibody Combination in Early Asymptomatic SARS-CoV-2 Infection: A Randomized Clinical Trial.2021
34000246Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial.Lancet Oncol2021
34210852Sequencing of 640,000 exomes identifies <i>GPR75</i> variants associated with protection from obesity.Science2021
33651675Passive Prophylactic Administration with a Single Dose of Anti-Fel d 1 Monoclonal Antibodies REGN1908-1909 in Cat Allergen-induced Allergic Rhinitis: A Randomized, Double-Blind, Placebo-controlled Clinical Trial.American Journal of Respiratory and Critical Care Medicine2021
34347950Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19.New England Journal of Medicine2021
34302758Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial.Lancet Respiratory Medicine,The2021
34351414Evaluation of Intravitreal Aflibercept for the Treatment of Severe Nonproliferative Diabetic Retinopathy: Results From the PANORAMA Randomized Clinical Trial.JAMA Ophthalmology2021
33199274Efficacy and safety of fasinumab in patients with chronic low back pain: a phase II/III randomised clinical trial.Annals of the Rheumatic Diseases2021
33288630Humanized C3 Mouse: A Novel Accelerated Model of C3 Glomerulopathy.Journal of the American Society of Nephrology : JASN2021
33332778REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19.N Engl J Med2021
32897368Suptavumab for the Prevention of Medically Attended Respiratory Syncytial Virus Infection in Preterm Infants.Clin Infect Dis2021
34919442Humanization of T cell-mediated immunity in mice.Science immunology2021
34662886Exome sequencing and analysis of 454,787 UK Biobank participants.Nature2021
34706171Efficacy and Safety of Itepekimab in Patients with Moderate-to-Severe Asthma.New England Journal of Medicine2021
34879449Dupilumab in Children with Uncontrolled Moderate-to-Severe Asthma.N Engl J Med2021
32574587Efficacy and safety of dupilumab with concomitant topical corticosteroids in children 6 to 11 years old with severe atopic dermatitis: A randomized, double-blinded, placebo-controlled phase 3 trial.J Am Acad Dermatol2020
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