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Author Details

Susan L Holbeck
National Cancer Institute
1983
47
30
PMIDPaper TitleJournal TitlePublished Year
30577754Predicting tumor cell line response to drug pairs with deep learning.BMC Bioinformatics2018
30577754Predicting tumor cell line response to drug pairs with deep learning.BMC Bioinformatics2018
28446463The National Cancer Institute ALMANAC: A Comprehensive Screening Resource for the Detection of Anticancer Drug Pairs with Enhanced Therapeutic Activity.Cancer Res2017
28446463The National Cancer Institute ALMANAC: A Comprehensive Screening Resource for the Detection of Anticancer Drug Pairs with Enhanced Therapeutic Activity.Cancer Res2017
28158293Phosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assay.PLoS One2017
28158293Phosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assay.PLoS One2017
25446780An in silico screen links gene expression signatures to drug response in glioblastoma stem cells.Pharmacogenomics J2015
25446780An in silico screen links gene expression signatures to drug response in glioblastoma stem cells.Pharmacogenomics J2015
24885658Gene expression profiling of 49 human tumor xenografts from in vitro culture through multiple in vivo passages--strategies for data mining in support of therapeutic studies.BMC Genomics2014
24885658Gene expression profiling of 49 human tumor xenografts from in vitro culture through multiple in vivo passages--strategies for data mining in support of therapeutic studies.BMC Genomics2014
23856246The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology.Cancer Res2013
23856246The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology.Cancer Res2013
22305747Antiproliferative mechanisms of action of the flavin dehydrogenase inhibitors diphenylene iodonium and di-2-thienyliodonium based on molecular profiling of the NCI-60 human tumor cell panel.Biochem Pharmacol2012
22305747Antiproliferative mechanisms of action of the flavin dehydrogenase inhibitors diphenylene iodonium and di-2-thienyliodonium based on molecular profiling of the NCI-60 human tumor cell panel.Biochem Pharmacol2012
21636706Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo.Neuro Oncol2011
21636706Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo.Neuro Oncol2011
20375240Expression profiling of nuclear receptors in the NCI60 cancer cell panel reveals receptor-drug and receptor-gene interactions.Mol Endocrinol2010
21031001Utilizing targeted cancer therapeutic agents in combination: novel approaches and urgent requirements.Nat Rev Drug Discov2010
20442306Analysis of Food and Drug Administration-approved anticancer agents in the NCI60 panel of human tumor cell lines.Mol Cancer Ther2010
20375240Expression profiling of nuclear receptors in the NCI60 cancer cell panel reveals receptor-drug and receptor-gene interactions.Mol Endocrinol2010
21031001Utilizing targeted cancer therapeutic agents in combination: novel approaches and urgent requirements.Nat Rev Drug Discov2010
20442306Analysis of Food and Drug Administration-approved anticancer agents in the NCI60 panel of human tumor cell lines.Mol Cancer Ther2010
19633067Identification of compounds that correlate with ABCG2 transporter function in the National Cancer Institute Anticancer Drug Screen.Mol Pharmacol2009
19633067Identification of compounds that correlate with ABCG2 transporter function in the National Cancer Institute Anticancer Drug Screen.Mol Pharmacol2009
17520257Glut-1 as a therapeutic target: increased chemoresistance and HIF-1-independent link with cell turnover is revealed through COMPARE analysis and metabolomic studies.Cancer Chemother Pharmacol2008
17520257Glut-1 as a therapeutic target: increased chemoresistance and HIF-1-independent link with cell turnover is revealed through COMPARE analysis and metabolomic studies.Cancer Chemother Pharmacol2008
17245351Adenovirus 5 fibers mutated at the putative HSPG-binding site show restricted retargeting with targeting peptides in the HI loop.Mol Ther2007
17942930Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage.Cancer Res2007
17245351Adenovirus 5 fibers mutated at the putative HSPG-binding site show restricted retargeting with targeting peptides in the HI loop.Mol Ther2007
17942930Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage.Cancer Res2007
16376301Correlation of PIK3Ca mutations with gene expression and drug sensitivity in NCI-60 cell lines.Biochem Biophys Res Commun2006
16798938Bisindenoisoquinoline bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity.Mol Pharmacol2006
16546986Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt.Mol Cancer Ther2006
16397212Ligand-directed surface profiling of human cancer cells with combinatorial peptide libraries.Cancer Res2006
16489930Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product.Biochem J2006
16982767Anticancer activity of BIM-46174, a new inhibitor of the heterotrimeric Galpha/Gbetagamma protein complex.Cancer Res2006
16376301Correlation of PIK3Ca mutations with gene expression and drug sensitivity in NCI-60 cell lines.Biochem Biophys Res Commun2006
16798938Bisindenoisoquinoline bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity.Mol Pharmacol2006
16982767Anticancer activity of BIM-46174, a new inhibitor of the heterotrimeric Galpha/Gbetagamma protein complex.Cancer Res2006
16489930Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product.Biochem J2006
16397212Ligand-directed surface profiling of human cancer cells with combinatorial peptide libraries.Cancer Res2006
16546986Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt.Mol Cancer Ther2006
15748285HLA class I and II genotype of the NCI-60 cell lines.J Transl Med2005
15655411Cytotoxicities of three rebeccamycin derivatives in the National Cancer Institute screening of 60 human tumor cell lines.Anticancer Drugs2005
15748285HLA class I and II genotype of the NCI-60 cell lines.J Transl Med2005
15655411Cytotoxicities of three rebeccamycin derivatives in the National Cancer Institute screening of 60 human tumor cell lines.Anticancer Drugs2005
15120034Update on NCI in vitro drug screen utilities.Eur J Cancer2004
15501957Components of the cell death machine and drug sensitivity of the National Cancer Institute Cell Line Panel.Clin Cancer Res2004
15541957Transcription profiling of gene expression in drug discovery and development: the NCI experience.Eur J Cancer2004
15252146In vitro evaluation of dimethane sulfonate analogues with potential alkylating activity and selective renal cell carcinoma cytotoxicity.Mol Cancer Ther2004
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Collaborators

Wash Benaroya Research Institute at Virginia Mason
Co-authored papers 12
National Cancer Institute, National Institutes of Health
Co-authored papers 7
Center for Cancer Research, National Cancer Institute
Co-authored papers 5
Co-authored papers 3
Mayo Clinic
Co-authored papers 2
Center for Cancer Research, National Cancer Institute
Co-authored papers 2
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Co-authored papers 2
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Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 1
Rutgers Cancer Institute of New Jersey
Co-authored papers 1
Rutgers Cancer Institute of New Jersey
Co-authored papers 1
Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 1
National Cancer Institute
Co-authored papers 1
Inc.Foster CityCA.
Co-authored papers 1
University of Chicago
Co-authored papers 1
Co-authored papers 1
Stanford University School of Medicine
Co-authored papers 1
Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 1
Institute of Biomedical Engineering (IBME), University of Oxford
Co-authored papers 1
Frederick National Laboratory for Cancer Research, Inc.
Co-authored papers 1
University of Chicago
Co-authored papers 1
National Cancer Institute, National Institutes of Health
Co-authored papers 1
University of Illinois Urbana-Champaign
Co-authored papers 1
Center for Cancer Research, National Cancer Institute
Co-authored papers 1
Meyer Cancer Center
Co-authored papers 1
Johns Hopkins School of Medicine, National Cancer Institute, Princeton University, University of Colorado Anschutz Medical Campus, University of Pittsburgh, University of Washington
Co-authored papers 1
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Rutgers Cancer Institute of New Jersey
Co-authored papers 1
Argonne National Laboratory
Co-authored papers 1
University of Chicago
Co-authored papers 1