Author details

Full Name

Piero Marchetti

Affiliation

ORCID

Career Start Year

1981

Papers

495

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36988639	Inhibition of the type 1 diabetes candidate gene PTPN2 aggravates TNF-Î±-induced human beta cell dysfunction and death.		2023
37745505	Interferon-Î± promotes neo-antigen formation and preferential HLA-B-restricted antigen presentation in pancreatic Î²-cells.		2023
37587148	Unveiling nanoscale optical signatures of cytokine-induced Î²-cell dysfunction.		2023
38076935	Differential CpG methylation at in the early establishment of beta cell heterogeneity.		2023
37148359	The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes.	Diabetologia	2023
37466955	Angiotensin I-converting enzyme type 2 expression is increased in pancreatic islets of type 2 diabetic donors.		2023
36824360	A long non-coding RNA that harbors a SNP associated with type 2 diabetes regulates the expression of gene in pancreatic beta cells.		2023
36995380	GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models.		2023
34718610	Gain of Function of Malate Dehydrogenase 2 and Familial Hyperglycemia.	J Clin Endocrinol Metab	2022
36371562	Single-cell imaging of Î± and Î² cell metabolic response to glucose in living human Langerhans islets.	Communications Biology	2022
35906204	Reduced miR-184-3p expression protects pancreatic Î²-cells from lipotoxic and proinflammatory apoptosis in type 2 diabetes via CRTC1 upregulation.	Cell Death Discovery	2022
36103539	Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic Î² cells.	Science advances	2022
35954309	The Protective Action of Metformin against Pro-Inflammatory Cytokine-Induced Human Islet Cell Damage and the Mechanisms Involved.	Cells	2022
35953581	Every islet matters: improving the impact of human islet research.	Nature Metabolism	2022
36345338	Mining the transcriptome of target tissues of autoimmune and degenerative pancreatic Î²-cell and brain diseases to discover therapies.	iScience	2022
35948367	Islet Gene View-a tool to facilitate islet research.	Life Sci Alliance	2022
35806437	The Role of Beta Cell Recovery in Type 2 Diabetes Remission.	International Journal of Molecular Sciences	2022
36134336	Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways.	iScience	2022
35676825	In vivo and in vitro characterization of GL0034, a novel long-acting glucagon-like peptide-1 receptor agonist.	Diabetes, Obesity and Metabolism	2022
35612429	The p66Shc Protein Mediates Insulin Resistance and Secretory Dysfunction in Pancreatic Î²-Cells Under Lipotoxic Conditions.		2022
36060810	In depth functional characterization of human induced pluripotent stem cell-derived beta cells and .	Frontiers in Cell and Developmental Biology	2022
35476777	Glucose-Dependent miR-125b Is a Negative Regulator of Î²-Cell Function.		2022
35359976	Increased Expression of Viral Sensor MDA5 in Pancreatic Islets and in Hormone-Negative Endocrine Cells in Recent Onset Type 1 Diabetic Donors.	Frontiers in Immunology	2022
36415826	A single-cell human islet interactome atlas identifies disrupted autocrine and paracrine communications in type 2 diabetes.	NAR Genomics and Bioinformatics	2022
36518246	ADAR1-dependent editing regulates human Î²Â cell transcriptome diversity during inflammation.		2022
33909390	Treating Type 1 Diabetes by Pancreas Transplant Alone: A Cohort Study on Actual Long-term (10 Years) Efficacy and Safety.	Transplantation	2022
34499239	Protective effects of Stevia rebaudiana extracts on beta cells in lipotoxic conditions.	Acta Diabetologica	2022
34644572	TIGER: The gene expression regulatory variation landscape of human pancreatic islets.	Cell Rep	2021
34241569	A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis.	Islets	2021
33486469	DNAJC3 deficiency induces Î²-cell mitochondrial apoptosis and causes syndromic young-onset diabetes.	European Journal of Endocrinology	2021
34056599	Correction to 'Integration of single-cell datasets reveals novel transcriptomic signatures of Î²-cells in human type 2 diabetes'.	NAR Genomics and Bioinformatics	2021
33730570	Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion.	Cell Reports	2021
33669901	Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis.	Biomolecules	2021
33773604	Endogenous mitochondrial double-stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells.	Autoimmunity Highlights	2021
34245223	First World Consensus Conference on pancreas transplantation: Part II - recommendations.	Am J Transplant	2021
34245116	First world consensus conference on pancreas transplantation: Part I-Methods and results of literature search.	American Journal of Transplantation	2021
33129839	Noradrenergic fibers are associated with beta-cell dedifferentiation and impaired beta-cell function in humans.	Metabolism: Clinical and Experimental	2021
34575477	Spatiotemporal Correlation Spectroscopy Reveals a Protective Effect of Peptide-Based GLP-1 Receptor Agonism against Lipotoxicity on Insulin Granule Dynamics in Primary Human Î²-Cells.	Pharmaceutics	2021
34440644	Mast Cells and the Pancreas in Human Type 1 and Type 2 Diabetes.	Cells	2021
34884624	Î²-Cell Pathophysiology: A Review of Advanced Optical Microscopy Applications.	International Journal of Molecular Sciences	2021
31388097	The expression of genes in top obesity-associated loci is enriched in insula and substantia nigra brain regions involved in addiction and reward.	International Journal of Obesity	2020
31796987	Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity.	Diabetologia	2020
31900242	Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells.	Stem Cell Research and Therapy	2020
32308449	Insulin Autoimmune Syndrome (Hirata Disease): A Comprehensive Review Fifty Years After Its First Description.	Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy	2020
32351176	Induction and Immunosuppressive Management of Pancreas Transplant Recipients.	Current Pharmaceutical Design	2020
31877117	Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia.	JCI Insight	2020
31873789	A nanobody-based nuclear imaging tracer targeting dipeptidyl peptidase 6 to determine the mass of human beta cell grafts in mice.	Diabetologia	2020
32284404	The T1D-associated lncRNA modulates human pancreatic Î² cell inflammation by allele-specific stabilization of mRNA.	Proceedings of the National Academy of Sciences of the United States of America	2020
32476252	Preclinical evaluation of tyrosine kinase 2 inhibitors for human beta-cell protection in type 1 diabetes.	Diabetes, Obesity and Metabolism	2020
32455046	Subcapsular Renal Hematoma in Simultaneous Pancreas Kidney Transplantation.		2020