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Author Details

Mitchell P Fink
University of Pittsburgh School of Medicine
1974
312
79
PMIDPaper TitleJournal TitlePublished Year
30365818Ethacrynic acid decreases expression of proinflammatory intestinal wall cytokines and ameliorates gastrointestinal stasis in murine postoperative ileus.Clinics (Sao Paulo)2018
28215131Angiotensin II for the Treatment of High-Output Shock 3 (ATHOS-3): protocol for a phase III, double-blind, randomised controlled trial.Crit Care Resusc2017
26863125THE EPITHELIUM AS A TARGET IN SEPSIS.Shock2016
27776698Ethyl pyruvate modulates delayed paralysis following thoracic aortic ischemia reperfusion in mice.J Vasc Surg2016
24371250Successful use of extracorporeal membrane oxygenation in an adult patient with toxic shock-induced heart failure.J Intensive Care Med2015
26376246Integrated Critical Care Organizations: A Personal View.Crit Care Med2015
25560289Cytopathic hypoxia and sepsis: is mitochondrial dysfunction pathophysiologically important or just an epiphenomenon.Pediatr Crit Care Med2015
24022070Animal models of sepsis.Virulence2014
25672458Analyzing the value of monitoring duodenal mucosal perfusion using photoplethysmography.Crit Care2014
25190187Strategies to improve drug development for sepsis.Nat Rev Drug Discov2014
25029244HMGB1 as a drug target in staphylococcal pneumonia.Crit Care2014
24836806Nitric oxide synthase and vascular dysfunction in sepsis: should we target nitric oxide synthase 1, nitric oxide synthase 2, both, or neither?Crit Care Med2014
24534975Acute pancreatitis: a lame duct problem?*.Crit Care Med2014
24599095p-Hydroxyphenylpyruvate, an intermediate of the Phe/Tyr catabolism, improves mitochondrial oxidative metabolism under stressing conditions and prolongs survival in rats subjected to profound hemorrhagic shock.PLoS One2014
23979366Recombinant soluble thrombomodulin as an adjunctive treatment for sepsis and disseminated intravascular coagulation: relatively safe and possibly effective.Crit Care Med2013
22175298L-arginine is a radioprotector for hematopoietic progenitor cells.Radiat Res2012
23351230Pathophysiology of perioperative anaemia.Best Pract Res Clin Anaesthesiol2012
22829588Identification of a novel pathway of transforming growth factor-β1 regulation by extracellular NAD+ in mouse macrophages: in vitro and in silico studies.J Biol Chem2012
22249033Matrix metalloproteinase-8 as a potential drug target for the therapy of sepsis.Crit Care Med2012
22425854Pharmacological effects of inhaled methane: plausible or not?Crit Care Med2012
22202712A comparison of critical care research funding and the financial burden of critical illness in the United States.Crit Care Med2012
19959189Effects of ethyl pyruvate and other α-keto carboxylic acid derivatives in a rat model of multivisceral ischemia and reperfusion.J Surg Res2011
21828244Transcriptomic response of murine liver to severe injury and hemorrhagic shock: a dual-platform microarray analysis.Physiol Genomics2011
21446966Organized staffing directed by intensivists improves outcomes for critically ill patients.Am J Transplant2011
21217488Postischemic treatment with ethyl pyruvate prevents adenosine triphosphate depletion, ameliorates inflammation, and decreases thrombosis in a murine model of hind-limb ischemia and reperfusion.J Trauma2011
20230800The biochemical basis for the anti-inflammatory and cytoprotective actions of ethyl pyruvate and related compounds.Biochem Pharmacol2010
21244758Ethyl pyruvate therapy attenuates experimental severe arthritis caused by type II collagen (CII) in the mouse (CIA).Int J Immunopathol Pharmacol2010
20451918The therapeutic potential of pyruvate.J Surg Res2010
20664360Preconditioning with high mobility group box 1 (HMGB1) induces lipoteichoic acid (LTA) tolerance.J Immunother2010
20194162Editorial: Lepromatous leprosy, lipids, and lessons in immunology: what we can learn by using modern methods to study an ancient disease.J Leukoc Biol2010
18650778Drag-reducing hyaluronic acid increases survival in profoundly hemorrhaged rats.Shock2009
19609124Sepsis, ghrelin, the cholinergic anti-inflammatory pathway, gut mucosal hyperpermeability, and high-mobility group box 1.Crit Care Med2009
19643739Editorial: Hemopexin: newest member of the anti-inflammatory mediator club.J Leukoc Biol2009
19358737Prolonged treatment with N-acetylcystine delays liver recovery from acetaminophen hepatotoxicity.Crit Care2009
19415334Comparison of distinct protein isoforms of the receptor for advanced glycation end-products expressed in murine tissues and cell lines.Cell Tissue Res2009
19494177Bile high-mobility group box 1 contributes to gut barrier dysfunction in experimental endotoxemia.Am J Physiol Regul Integr Comp Physiol2009
19454652Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis.J Leukoc Biol2009
19448468Peroxisome proliferator activator receptor gamma (PPARgamma) agonists as therapeutic adjuncts in critical illness: efficacy might be suboptimal in elderly patients.Crit Care Med2009
18835526A phase II multicenter double-blind placebo-controlled study of ethyl pyruvate in high-risk patients undergoing cardiac surgery with cardiopulmonary bypass.J Cardiothorac Vasc Anesth2009
19050619Ethyl pyruvate reduces the development of zymosan-induced generalized inflammation in mice.Crit Care Med2009
18948848Beneficial effects of ethyl pyruvate in a mouse model of spinal cord injury.Shock2009
19027919Ethyl pyruvate ameliorates liver injury secondary to severe acute pancreatitis.J Surg Res2009
18193822Targeting mitochondria.Acc Chem Res2008
18827799Animal models of sepsis and its complications.Kidney Int2008
18687905Preconditioning with high mobility group box 1 (HMGB1) induces lipopolysaccharide (LPS) tolerance.J Leukoc Biol2008
18443482Ethyl pyruvate.Curr Opin Anaesthesiol2008
18403588Neuropeptide modulators of high mobility group box 1 secretion as potential therapeutic agents for severe sepsis.Am J Pathol2008
17179468Structural requirements for optimized delivery, inhibition of oxidative stress, and antiapoptotic activity of targeted nitroxides.J Pharmacol Exp Ther2007
17903310Bench-to-bedside review: High-mobility group box 1 and critical illness.Crit Care2007
17973549Ethyl pyruvate, a potentially effective mitigator of damage after total-body irradiation.Radiat Res2007
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Collaborators

University of Pittsburgh
Co-authored papers 16
University of Pittsburgh
Co-authored papers 10
Cincinnati Children's Hospital Medical Center
Co-authored papers 8
University of Pittsburgh Medical Center
Co-authored papers 8
University of Pittsburgh Medical Center
Co-authored papers 8
The Pennsylvania State University, University Park
Co-authored papers 6
Center for Molecular Imaging, University of Pittsburgh School of Medicine
Co-authored papers 6
Center for Free Radical and Antioxidant Health, University of Pittsburgh
Co-authored papers 6
University of Pittsburgh
Co-authored papers 5
Spectral Medical Inc.
Co-authored papers 5
Massachusetts General Hospital
Co-authored papers 4
Co-authored papers 4
Erasme Hospital, Universite Libre de Bruxelles
Co-authored papers 4
Beth Israel Deaconess Medical Center, Harvard Medical School
Co-authored papers 4
University of Pittsburgh
Co-authored papers 3
University of Pittsburgh School of Medicine
Co-authored papers 3
St. Michael's Hospital
Co-authored papers 3
Infectious Disease Division at Brown University Warren Alpert Medical School
Co-authored papers 3
Geisel School of Medicine at Dartmouth
Co-authored papers 3
University of Pittsburgh Medical School
Co-authored papers 3
University of Vermont Medical Centre
Co-authored papers 3
University of Michigan Medical Center ann arbor
Co-authored papers 3
Cincinnati Children's Hospital Medical Center, University of Cincinnati
Co-authored papers 2
The Clinical Research, University of Pittsburgh
Co-authored papers 2
University of Pittsburgh
Co-authored papers 2
Vantage Research Inc.
Co-authored papers 2
Clinical Center, National Institutes of Health
Co-authored papers 2
Pennsylvania State University-Milton S. Hershey Medical Center
Co-authored papers 2
University of Tennessee
Co-authored papers 2
Veterans Affairs Medical Center San Diego
Co-authored papers 2