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Author Details

Nhu-An Pham
Princess Margaret Cancer Centre, University Health Network
1998
53
24
PMIDPaper TitleJournal TitlePublished Year
36214668Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non-Small Cell Lung Cancer.Mol Cancer Res2023
36535627Single-Cell Analysis Reveals Transcriptomic Features of Drug-Tolerant Persisters and Stromal Adaptation in a Patient-Derived EGFR-Mutated Lung Adenocarcinoma Xenograft Model.J Thorac Oncol2023
34648945Lung Cancer Driven by BRAF<sup>G469V</sup> Mutation Is Targetable by EGFR Kinase Inhibitors.J Thorac Oncol2022
35383171Integrative analysis of non-small cell lung cancer patient-derived xenografts identifies distinct proteotypes associated with patient outcomes.Nat Commun2022
36551709CT Radiomics and Whole Genome Sequencing in Patients with Pancreatic Ductal Adenocarcinoma: Predictive Radiogenomics Modeling.Cancers (Basel)2022
36439025Optimizing Drug Response Study Design in Patient-Derived Tumor Xenografts.Cancer Inform2022
34284202Antitumor efficacy of XPO1 inhibitor Selinexor in KRAS-mutant lung adenocarcinoma patient-derived xenografts.Transl Oncol2021
34788078Assessing therapy response in patient-derived xenografts.Sci Transl Med2021
34011980Patient-derived tumor xenograft and organoid models established from resected pancreatic, duodenal and biliary cancers.Sci Rep2021
32521388BRAF V600E mutation and MET amplification as resistance pathways of the second-generation anaplastic lymphoma kinase (ALK) inhibitor alectinib in lung cancer.Lung Cancer2020
31694835Organoid Cultures as Preclinical Models of Non-Small Cell Lung Cancer.Clin Cancer Res2020
32094923A drug discovery platform to identify compounds that inhibit EGFR triple mutants.Nat Chem Biol2020
32903271Cancer proteome and metabolite changes linked to SHMT2.PLoS One2020
33023139Targeting and Efficacy of Novel mAb806-Antibody-Drug Conjugates in Malignant Mesothelioma.Pharmaceuticals (Basel)2020
32447118EGFR-mutated lung adenocarcinomas from patients who progressed on EGFR-inhibitors show high engraftment rates in xenograft models.Lung Cancer2020
30670085Human double negative T cells target lung cancer via ligand-dependent mechanisms that can be enhanced by IL-15.J Immunother Cancer2019
31330989Somatic Alteration Burden Involving Non-Cancer Genes Predicts Prognosis in Early-Stage Non-Small Cell Lung Cancer.Cancers (Basel)2019
31383733CD45<sup>+</sup>CD326<sup>+</sup> Cells are Predictive of Poor Prognosis in Non-Small Cell Lung Cancer Patients.Clin Cancer Res2019
29145543Association of Ipilimumab With Safety and Antitumor Activity in Women With Metastatic or Recurrent Human Papillomavirus-Related Cervical Carcinoma.JAMA Oncol2018
30093452Targeting the CDK4/6-Rb Pathway Enhances Response to PI3K Inhibition in <i>PIK3CA</i>-Mutant Lung Squamous Cell Carcinoma.Clin Cancer Res2018
30108107A Clinical and Molecular Phase II Trial of Oral ENMD-2076 in Ovarian Clear Cell Carcinoma (OCCC): A Study of the Princess Margaret Phase II Consortium.Clin Cancer Res2018
27750381Molecular heterogeneity of non-small cell lung carcinoma patient-derived xenografts closely reflect their primary tumors.Int J Cancer2017
29156674Novel combinations of PI3K-mTOR inhibitors with dacomitinib or chemotherapy in PTEN-deficient patient-derived tumor xenografts.Oncotarget2017
26148229Integrin α11β1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in non-small cell lung cancer.Oncogene2016
27880766SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis.PLoS Biol2016
27613526An Anaplastic Lymphoma Kinase Immunohistochemistry-Negative but Fluorescence In Situ Hybridization-Positive Lung Adenocarcinoma Is Resistant to Crizotinib.J Thorac Oncol2016
26926157Cetuximab Inhibits T790M-Mediated Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in a Lung Adenocarcinoma Patient-Derived Xenograft Mouse Model.Clin Lung Cancer2016
25784717CHCHD2 Is Coamplified with EGFR in NSCLC and Regulates Mitochondrial Function and Cell Migration.Mol Cancer Res2015
26124487Clinical Utility of Patient-Derived Xenografts to Determine Biomarkers of Prognosis and Map Resistance Pathways in EGFR-Mutant Lung Adenocarcinoma.J Clin Oncol2015
26095073Patient-derived tumor xenograft models established from samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration.Lung Cancer2015
24453208Proteomic profiles of human lung adeno and squamous cell carcinoma using super-SILAC and label-free quantification approaches.Proteomics2014
25429762Integrated omic analysis of lung cancer reveals metabolism proteome signatures with prognostic impact.Nat Commun2014
20815376Primary tumor xenografts of human lung adeno and squamous cell carcinoma express distinct proteomic signatures.J Proteome Res2011
21352589The association between EGFR variant III, HPV, p16, c-MET, EGFR gene copy number and response to EGFR inhibitors in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.Head Neck Oncol2011
21081655The ability to form primary tumor xenografts is predictive of increased risk of disease recurrence in early-stage non-small cell lung cancer.Clin Cancer Res2011
20042973A multicenter phase II clinical trial of lapatinib (GW572016) in hormonally untreated advanced prostate cancer.Am J Clin Oncol2010
20113529Differential roles of cyclin D1 and D3 in pancreatic ductal adenocarcinoma.Mol Cancer2010
20197396Phase I combination of sorafenib and erlotinib therapy in solid tumors: safety, pharmacokinetic, and pharmacodynamic evaluation from an expansion cohort.Mol Cancer Ther2010
18924149Activation of Src and Src-associated signaling pathways in relation to hypoxia in human cancer xenograft models.Int J Cancer2009
17579866Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo.Cancer Chemother Pharmacol2008
18254976Immunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis.BMC Cancer2008
17326824Quantitative image analysis of immunohistochemical stains using a CMYK color model.Diagn Pathol2007
17895832Dissociation of gemcitabine sensitivity and protein kinase B signaling in pancreatic ductal adenocarcinoma models.Pancreas2007
17409959Integrin-linked kinase inhibitor KP-392 demonstrates clinical benefits in an orthotopic human non-small cell lung cancer model.J Thorac Oncol2006
16435192A comparative study of cytoplasmic granules imaged by the real-time microscope, Nile Red and Filipin in fibroblasts from patients with lipid storage diseases.J Inherit Metab Dis2005
15486191The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice.Mol Cancer Ther2004
15306050Altered mitochondrial structure and motion dynamics in living cells with energy metabolism defects revealed by real time microscope imaging.Microsc Microanal2004
12879457Oxidative stress is generated via the mitochondrial respiratory chain during plant cell apoptosis.Cytometry A2003
11464217The BH3 domain of BAD fused to the Antennapedia peptide induces apoptosis via its alpha helical structure and independent of Bcl-2.Cell Death Differ2001
11262191Respiratory chain-generated oxidative stress following treatment of leukemic blasts with DNA-damaging agents.Exp Cell Res2001
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Collaborators

University Health Network, University of Toronto
Co-authored papers 40
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 19
University Health Network, Princess Margaret Cancer Centre
Co-authored papers 17
The Princess Margaret Cancer Centre/University of Toronto
Co-authored papers 15
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 12
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 10
Hospital for Sick Children, University of Toronto
Co-authored papers 10
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 9
National Cancer Center Exploratory Oncology Research & Clinical Trial Center
Co-authored papers 9
Hospital for Sick Children
Co-authored papers 8
Hospital for Sick Children
Co-authored papers 8
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 7
Sheffield Institute of Translational Neuroscience, University of Sheffield
Co-authored papers 7
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 6
Margaret Cancer Center
Co-authored papers 5
Yamagata Prefectural Central Hospital
Co-authored papers 5
Rosalind and Morris Goodman Cancer Institute, McGill University
Co-authored papers 5
Schroeder Arthritis Institute
Co-authored papers 5
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 5
Hospital for Sick Children
Co-authored papers 4
University of Toronto
Co-authored papers 4
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 4
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 4
Inha University Hospital
Co-authored papers 4
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 3
University of Toronto.
Co-authored papers 3
Harvard Medical School
Co-authored papers 3
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 3
Princess Margaret Cancer Centre, University Ave
Co-authored papers 3
Toronto General Hospital
Co-authored papers 3