Author details

Full Name

Alvaro Rada-Iglesias

Affiliation

ORCID

Career Start Year

2003

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37170707	The interaction between enhancer variants and environmental factors as an overlooked aetiological paradigm in human complex disease.		2023
36635295	Changes in PRC1 activity during interphase modulate lineage transition in pluripotent cells.		2023
36999617	POSTRE: a tool to predict the pathological effects of human structural variants.		2023
36468602	Identification of de novo variants in nonsyndromic cleft lip with/without cleft palate patients with low polygenic risk scores.	Mol Genet Genomic Med	2023
34528480	MiRNA-149 as a Candidate for Facial Clefting and Neural Crest Cell Migration.	J Dent Res	2022
35769926	Protocol to study sufficiency of -regulatory elements in mouse embryonic stem cells using a CRISPR-mediated knockin approach.	STAR Protocols	2022
35686641	Enhancer-gene specificity in development and disease.	Development (Cambridge)	2022
36335090	Epigenetic mechanisms of Strip2 in differentiation of pluripotent stem cells.	Cell Death Discov	2022
35672304	JMJD3 intrinsically disordered region links the 3D-genome structure to TGFÎ²-dependent transcription activation.	Nature Communications	2022
36482255	Current challenges in understanding the role of enhancers in disease.		2022
34599190	Enhancer-associated H3K4 methylation safeguards in vitro germline competence.	Nat Commun	2021
34021162	Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology.	Nat Commun	2021
34239060	Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility.	Nature Cell Biology	2021
34272393	The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo.	Nature Communications	2021
33654163	MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome.	Scientific Reports	2021
33501996	Virtual meeting, real and sound science: report of the 17 Meeting of the Spanish Society for Developmental Biology (SEBD-2020).		2021
34183853	Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness.	Nature Genetics	2021
35047836	Integrative approaches generate insights into the architecture of non-syndromic cleft lip with or without cleft palate.	HGG Adv	2021
32765580	Rare or Overlooked? Structural Disruption of Regulatory Domains in Human Neurocristopathies.	Frontiers in Genetics	2020
32243845	Epigenomic and Transcriptomic Changes During Human RPE EMT in a Stem Cell Model of Epiretinal Membrane Pathogenesis and Prevention by Nicotinamide.	Stem Cell Reports	2020
31896583	The formation of the thumb requires direct modulation of transcription by Hoxa13.	Proceedings of the National Academy of Sciences of the United States of America	2020
32451438	The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells.	Communications Biology	2020
31006630	Pathological ASXL1 Mutations and Protein Variants Impair Neural Crest Development.	Stem Cell Reports	2019
31840056	Dosage analysis of the 7q11.23 Williams region identifies as a major human gene patterning the modern human face and underlying self-domestication.	Science advances	2019
31673701	Polycomb proteins as organizers of 3D genome architecture in embryonic stem cells.	Briefings in Functional Genomics	2019
30554961	yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs.	Cell Stem Cell	2019
31233905	Transcriptional and epigenetic control of germline competence and specification.	Current Opinion in Cell Biology	2019
30982769	Modeling the Pathological Long-Range Regulatory Effects of Human Structural Variation with Patient-Specific hiPSCs.		2019
29273804	Is H3K4me1 at enhancers correlative or causative?	Nature Genetics	2018
30075122	Pioneering of Enhancer Landscapes during Pluripotent State Transitions.		2018
30452683	Mechanism suppressing H3K9 trimethylation in pluripotent stem cells and its demise by polyQ-expanded huntingtin mutations.	Human Molecular Genetics	2018
29858282	Forces driving the three-dimensional folding of eukaryotic genomes.	Molecular Systems Biology	2018
29438503	Lineage specific transcription factors and epigenetic regulators mediate TGFÎ²-dependent enhancer activation.	Nucleic Acids Research	2018
28007912	GARLIC: a bioinformatic toolkit for aetiologically connecting diseases and cell type-specific regulatory maps.	Human Molecular Genetics	2017
28872116	Chromatin Immunoprecipitation (ChIP) Protocol for Low-abundance Embryonic Samples.	Journal of Visualized Experiments	2017
29061670	Ready, Setâ¿¦Poised!: Polycomb targetÂ genes are bound by poised RNAÂ polymerase II throughout differentiation.	Molecular Systems Biology	2017
28087736	Imputation of orofacial clefting data identifies novel risk loci and sheds light on the genetic background of cleft lip Â± cleft palate and cleft palate only.	Hum Mol Genet	2017
28285903	PRC2 Facilitates the Regulatory Topology Required for Poised Enhancer Function during Pluripotent Stem Cell Differentiation.		2017
27974217	Epigenomics-Based Identification of Major Cell Identity Regulators within Heterogeneous Cell Populations.	Cell Reports	2016
26748758	Foxd3 Promotes Exit from Naive Pluripotency through Enhancer Decommissioning and Inhibits Germline Specification.		2016
25205712	Genetic variation within transcriptional regulatory elements and its implications for human disease.	Biological Chemistry	2014
23449470	Pioneering barren land: mitotic bookmarking by transcription factors.	Developmental Cell	2013
23650634	Human genetic variation within neural crest enhancers: molecular and phenotypic implications.	Philosophical Transactions of the Royal Society B: Biological Sciences	2013
22981823	Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest.		2012
22968620	The homeodomain-leucine zipper (HD-Zip) class I transcription factors ATHB7 and ATHB12 modulate abscisic acid signalling by regulating protein phosphatase 2C and abscisic acid receptor gene activities.	Plant Molecular Biology	2012
21658297	Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease.	Genome Medicine	2011
21160473	A unique chromatin signature uncovers early developmental enhancers in humans.	Nature	2011
21183938	Sequence-specific regulator Prdm14 safeguards mouse ESCs from entering extraembryonic endoderm fates.	Nat Struct Mol Biol	2011
22011431	Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa.	BMC Cancer	2011
20534969	Integrative epigenomic and genomic analysis of malignant pheochromocytoma.	Exp Mol Med	2010