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Author Details

Zhengdong D Zhang
2006
69
32
PMIDPaper TitleJournal TitlePublished Year
37246648Frailty Resilience Score: A Novel Measure of Frailty Resilience Associated With Protection From Frailty and Survival.2023
36869225Rare coding variants as risk modifiers of the 22q11.2 deletion implicate postnatal cortical development in syndromic schizophrenia.Mol Psychiatry2023
37118361Unravelling genetic components of longevity.2022
36125934Protocol for gene annotation, prediction, and validation of genomic gene expansion.STAR Protocols2022
36583016Substance abuse and the risk of severe COVID-19: Mendelian randomization confirms the causal role of opioids but hints a negative causal effect for cannabinoids.2022
34758328Genomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation.Cell Rep2021
37117627Rare genetic coding variants associated with human longevity and protection against age-related diseases.Nat Aging2021
32015465Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion.Mol Psychiatry2021
34040254Enhancer release and retargeting activates disease-susceptibility genes.Nature2021
34197020Genetic signature of human longevity in PKC and NF-κB signaling.Aging Cell2021
34556881Transposon-triggered innate immune response confers cancer resistance to the blind mole rat.Nat Immunol2021
34654853Deep post-GWAS analysis identifies potential risk genes and risk variants for Alzheimer's disease, providing new insights into its disease mechanisms.Scientific Reports2021
34596321Ectopic cervical thymi and no thymic involution until midlife in naked mole rats.Aging Cell2021
32719537Genetics of extreme human longevity to guide drug discovery for healthy ageing.Nat Metab2020
32578072Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways.GeroScience2020
32726638Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity.Cell Rep2020
31002797SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.Cell2019
31169292The nutritional environment determines which and how intestinal stem cells contribute to homeostasis and tumorigenesis.Carcinogenesis2019
29465290Global, integrated analysis of methylomes and transcriptomes from laser capture microdissected bronchial and alveolar cells in human lung.Epigenetics2018
29300829PGA: post-GWAS analysis for disease gene identification.2018
29615825Epigenetic alterations to Polycomb targets precede malignant transition in a mouse model of breast cancer.Scientific Reports2018
29077884HEDD: Human Enhancer Disease Database.Nucleic Acids Research2018
28212608Transcriptomic dynamics of breast cancer progression in the MMTV-PyMT mouse model.BMC Genomics2017
28351837Cyclin C regulates adipogenesis by stimulating transcriptional activity of CCAAT/enhancer-binding protein α.Journal of Biological Chemistry2017
28707419Translation fidelity coevolves with longevity.Aging Cell2017
29281626Integrated rare variant-based risk gene prioritization in disease case-control sequencing studies.PLoS Genetics2017
27704213Network analysis of mitonuclear GWAS reveals functional networks and tissue expression profiles of disease-associated genes.Human Genetics2017
27874830Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity.Elife2016
27179790Systems-level analysis of human aging genes shed new light on mechanisms of aging.Human Molecular Genetics2016
27163160Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan.Aging (Albany NY)2016
27449149MicroRNA expression and gene regulation drive breast cancer progression and metastasis in PyMT mice.Breast Cancer Research2016
27754856Integrated Post-GWAS Analysis Sheds New Light on the Disease Mechanisms of Schizophrenia.Genetics2016
25981510Whole-Genome Sequencing and Integrative Genomic Analysis Approach on Two 22q11.2 Deletion Syndrome Family Trios for Genotype to Phenotype Correlations.Human Mutation2015
25550505INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform.Proc Natl Acad Sci U S A2015
25645816Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human.Aging Cell2015
26729707DNA repair in species with extreme lifespan differences.Aging (Albany NY)2015
26579211RNA:DNA hybrids in the human genome have distinctive nucleotide characteristics, chromatin composition, and transcriptional relationships.Epigenetics and Chromatin2015
24875834Mosaic epigenetic dysregulation of ectodermal cells in autism spectrum disorder.PLoS Genet2014
24981598Comparative genetics of longevity and cancer: insights from long-lived rodents.Nat Rev Genet2014
23478400The origin, evolution, and functional impact of short insertion-deletion variants identified in 179 human genomes.Genome Res2013
24082110Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage.Proc Natl Acad Sci U S A2013
23946504SubNet: a Java application for subnetwork extraction.2013
23975782A brief introduction to tiling microarrays: principles, concepts, and applications.Methods in Molecular Biology2013
22942009The Einstein Genome Gateway using WASP - a high throughput multi-layered life sciences portal for XSEDE.Studies in Health Technology and Informatics2012
22344438A systematic survey of loss-of-function variants in human protein-coding genes.Science2012
21787423Identification of genomic indels and structural variations using split reads.BMC Genomics2011
21349863ACT: aggregation and correlation toolbox for analyses of genome tracks.Bioinformatics2011
21293372Mapping copy number variation by population-scale genome sequencing.Nature2011
20210993Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates.Genome Biol2010
21034510Detection of copy number variation from array intensity and sequencing read depth using a stepwise Bayesian model.BMC Bioinformatics2010
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The Genome Center at Washington University, Washington University School of Medicine
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