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Author Details

Winfried Edelmann
Albert Einstein College of Medicine
1989
158
63
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37012205Vaccination and Microbiota Manipulation Approaches for Colon Cancer Prevention in Rodent Models.Cancer Prev Res (Phila)2023
36377656Blockade of the immunosuppressive KIR2DL5/PVR pathway elicits potent human NK cell-mediated antitumor immunity.J Clin Invest2022
35634291Genome Replication Is Associated With Release of Immunogenic DNA Waste.Front Immunol2022
35688320Loss of MMR and TGFBR2 Increases the Susceptibility to Microbiota-Dependent Inflammation-Associated Colon Cancer.Cell Mol Gastroenterol Hepatol2022
33299182H1 histones control the epigenetic landscape by local chromatin compaction.Nature2021
34003775The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells.Cancer Res2021
34224739Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity With Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse Model.Gastroenterology2021
32354835Molecular structures and mechanisms of DNA break processing in mouse meiosis.Genes Dev2020
32800616Corrigendum to "Caspase 9 is constitutively activated in mouse oocytes and plays a key role in oocyte elimination during meiotic prophase progression" [Dev. Biol. Vol.377 (2013) 213-223].Dev Biol2020
30615115Homozygous hydroxymethylbilane synthase knock-in mice provide pathogenic insights into the severe neurological impairments present in human homozygous dominant acute intermittent porphyria.Hum Mol Genet2019
30944090Mutation of the ATPase Domain of MutS Homolog-5 (MSH5) Reveals a Requirement for a Functional MutSγ Complex for All Crossovers in Mammalian Meiosis.G3 (Bethesda)2019
30312299MutLγ promotes repeat expansion in a Fragile X mouse model while EXO1 is protective.PLoS Genet2018
28711786EXO1 suppresses double-strand break induced homologous recombination between diverged sequences in mammalian cells.DNA Repair (Amst)2017
28276606The ISWI ATPase Smarca5 (Snf2h) Is Required for Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells.Stem Cells2017
29069730Inhibition of colorectal cancer genomic copy number alterations and chromosomal fragile site tumor suppressor FHIT and WWOX deletions by DNA mismatch repair.Oncotarget2017
26708047Mouse models of DNA mismatch repair in cancer research.DNA Repair (Amst)2016
27262172A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies.Cancer Res2016
27261510MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development.Cancer Res2016
27221540Genomic Landscape of Colorectal Mucosa and Adenomas.Cancer Prev Res (Phila)2016
27246713Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation.Development2016
25213383Detection of coding microsatellite frameshift mutations in DNA mismatch repair-deficient mouse intestinal tumors.Mol Carcinog2015
26343801Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia.Nat Med2015
26160886EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.Nucleic Acids Res2015
26006007Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting.Nat Biotechnol2015
25429050Mesalazine and thymoquinone attenuate intestinal tumour development in Msh2(loxP/loxP) Villin-Cre mice.Gut2015
24013230The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair.Oncogene2014
25302077Evolutionarily conserved genetic interactions with budding and fission yeast MutS identify orthologous relationships in mismatch repair-deficient cancer cells.Genome Med2014
25036629Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells.Cell2014
24556366A functional cancer genomics screen identifies a druggable synthetic lethal interaction between MSH3 and PRKDC.Cancer Discov2014
24565511Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function.Cell Rep2014
24395368Seamless Ligation Cloning Extract (SLiCE) cloning method.Methods Mol Biol2014
23254285Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.J Exp Med2013
23754438Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes.Proc Natl Acad Sci U S A2013
23384561Caspase 9 is constitutively activated in mouse oocytes and plays a key role in oocyte elimination during meiotic prophase progression.Dev Biol2013
22241772SLiCE: a novel bacterial cell extract-based DNA cloning method.Nucleic Acids Res2012
22703640AIDing antibody diversity by error-prone mismatch repair.Semin Immunol2012
22863617Chemokine 25-induced signaling suppresses colon cancer invasion and metastasis.J Clin Invest2012
22451719The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination.J Exp Med2012
22439692Effect of caloric intake on Western-style diet-induced intestinal tumors in a mouse model for hereditary colon cancer.Nutr Cancer2012
22681890Hierarchical modularity and the evolution of genetic interactomes across species.Mol Cell2012
21436383Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model.Cancer Prev Res (Phila)2011
22100214Mismatch-mediated error prone repair at the immunoglobulin genes.Biomed Pharmacother2011
19931261An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents.Gastroenterology2010
20703099Genes essential for cell viability that are linked to tumor suppressor genes play a role in cancer susceptibility.Cell Cycle2010
20858091Conditional inactivation of MLH1 in thymic and naive T-cells in mice leads to a limited incidence of lymphoblastic T-cell lymphomas.Leuk Lymphoma2010
20934970Msh6 protects mature B cells from lymphoma by preserving genomic stability.Am J Pathol2010
20567595MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites.PLoS One2010
20624957PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance.Proc Natl Acad Sci U S A2010
20212136Cis lethal genetic interactions attenuate and alter p53 tumorigenesis.Proc Natl Acad Sci U S A2010
18930147Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes.Neurobiol Dis2009
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Collaborators

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Co-authored papers 63
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Co-authored papers 13
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Albert Einstein College of Medicine
Co-authored papers 8
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Hannover Medical School
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University of California San Francisco
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Co-authored papers 3
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Wonju Severance Christian Hospital
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Co-authored papers 2
Peer Bork
University of Wurzburg
Co-authored papers 2
Kevin G Hardwick
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Co-authored papers 1
John M Greally
Co-authored papers 1
Brian D Strahl
University of North Carolina
Co-authored papers 1
Tyler Jacks
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Eric E Bouhassira
Albert Einstein College of Medicine
Co-authored papers 1
Joseph A Katakowski
Pfizer Inc.
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Kevan M Shokat
University of California San Francisco
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Rituparna Mukhopadhyay
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John M Mariadason
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Peking University
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Release 1.2