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Author Details

Reto Guler
International Centre for Genetic Engineering and Biotechnology
1999
56
27
PMIDPaper TitleJournal TitlePublished Year
36950105COVID-19Base v3: Update of the knowledgebase for drugs and biomedical entities linked to COVID-19.Front Public Health2023
37626929Antisense Therapy for Infectious Diseases.Cells2023
35084027Intranasally administered S-MGB-364 displays antitubercular activity and modulates the host immune response to Mycobacterium tuberculosis infection.J Antimicrob Chemother2022
35895506Host-Directed Targeting of LincRNA-MIR99AHG Suppresses Intracellular Growth of <i>Mycobacterium tuberculosis</i>.Nucleic Acid Ther2022
36119114Lyl1-deficiency promotes inflammatory responses and increases mycobacterial burden in response to <i>Mycobacterium tuberculosis</i> infection in mice.Front Immunol2022
33980132Deletion of N-acetylmuramyl-L-alanine amidases alters the host immune response to <i>Mycobacterium tuberculosis</i> infection.Virulence2021
34739044IL-4i1 Regulation of Immune Protection During Mycobacterium tuberculosis Infection.J Infect Dis2021
34745105Targeting Molecular Inflammatory Pathways in Granuloma as Host-Directed Therapies for Tuberculosis.Front Immunol2021
34745081Evaluation of Berberine as an Adjunct to TB Treatment.Front Immunol2021
34220793IL-4-Responsive B Cells Are Detrimental During Chronic Tuberculosis Infection in Mice.Front Immunol2021
32792452Protocol for systematic review and meta-analysis: impact of statins as immune-modulatory agents on inflammatory markers in adults with chronic diseases.BMJ Open2020
31729564The gut microbiome in tuberculosis susceptibility and treatment response: guilty or not guilty?Cell Mol Life Sci2020
33055059Toward Preparing a Knowledge Base to Explore Potential Drugs and Biomedical Entities Related to COVID-19: Automated Computational Approach.JMIR Med Inform2020
30669987Transcriptionally induced enhancers in the macrophage immune response to Mycobacterium tuberculosis infection.BMC Genomics2019
30941122Differential Targeting of c-Maf, Bach-1, and Elmo-1 by microRNA-143 and microRNA-365 Promotes the Intracellular Growth of Mycobacterium tuberculosis in Alternatively IL-4/IL-13 Activated Macrophages.Front Immunol2019
30487528Statins: a viable candidate for host-directed therapy against infectious diseases.Nat Rev Immunol2019
30542107Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases.Mucosal Immunol2019
29346346Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice.Mucosal Immunol2018
30275010Deletion of Interleukin-4 Receptor Alpha-Responsive Keratinocytes in BALB/c Mice Does Not Alter Susceptibility to Cutaneous Leishmaniasis.Infect Immun2018
29712924Transcriptional landscape of Mycobacterium tuberculosis infection in macrophages.Sci Rep2018
28544982An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics.Eur J Med Chem2017
29061167Genome-wide profiling of transcribed enhancers during macrophage activation.Epigenetics Chromatin2017
28961913Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy.J Antimicrob Chemother2017
29067025IL-4Rα Signaling in Keratinocytes and Early IL-4 Production Are Dispensable for Generating a Curative T Helper 1 Response in <i>Leishmania major</i>-Infected C57BL/6 Mice.Front Immunol2017
28850106FANTOM5 CAGE profiles of human and mouse samples.Sci Data2017
27632901Topical Simvastatin as Host-Directed Therapy against Severity of Cutaneous Leishmaniasis in Mice.Sci Rep2016
31414702IRNdb: the database of immunologically relevant non-coding RNAs.Database (Oxford)2016
25790379IL-4Rα-dependent alternative activation of macrophages is not decisive for Mycobacterium tuberculosis pathology and bacterial burden in mice.PLoS One2015
26379013Host-directed drug therapy for tuberculosis.Nat Chem Biol2015
26376615Targeting Batf2 for infectious diseases and cancer.Oncotarget2015
26117544Redefining the transcriptional regulatory dynamics of classically and alternatively activated macrophages by deepCAGE transcriptomics.Nucleic Acids Res2015
25957166Batf2/Irf1 induces inflammatory responses in classically activated macrophages, lipopolysaccharides, and mycobacterial infection.J Immunol2015
25678556Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells.Science2015
24133190Statin therapy reduces the mycobacterium tuberculosis burden in human macrophages and in mice by enhancing autophagy and phagosome maturation.J Infect Dis2014
26015986Preclinical efficacy and safety of an anti-IL-1β vaccine for the treatment of type 2 diabetes.Mol Ther Methods Clin Dev2014
24670764A promoter-level mammalian expression atlas.Nature2014
24086542Simvastatin enhances protection against Listeria monocytogenes infection in mice by counteracting Listeria-induced phagosomal escape.PLoS One2013
22265677Syk kinase-coupled C-type lectin receptors engage protein kinase C-δ to elicit Card9 adaptor-mediated innate immunity.Immunity2012
22689578The C-type lectin receptor CLECSF8 (CLEC4D) is expressed by myeloid cells and triggers cellular activation through Syk kinase.J Biol Chem2012
21034845The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice.Microbes Infect2011
21287553PKCδ regulates IL-12p40/p70 production by macrophages and dendritic cells, driving a type 1 healer phenotype in cutaneous leishmaniasis.Eur J Immunol2011
21093494Blocking IL-1α but not IL-1β increases susceptibility to chronic Mycobacterium tuberculosis infection in mice.Vaccine2011
20390297CD28 and IL-4: two heavyweights controlling the balance between immunity and inflammation.Med Microbiol Immunol2010
20817877Limited role for lymphotoxin α in the host immune response to Mycobacterium tuberculosis.J Immunol2010
20041149The role of scavenger receptor B1 in infection with Mycobacterium tuberculosis in a murine model.PLoS One2009
17513796A virus-like particle-based vaccine selectively targeting soluble TNF-alpha protects from arthritis without inducing reactivation of latent tuberculosis.J Immunol2007
17913887Protein kinase C delta is essential for optimal macrophage-mediated phagosomal containment of Listeria monocytogenes.Proc Natl Acad Sci U S A2007
15793291Contribution of transmembrane tumor necrosis factor to host defense against Mycobacterium bovis bacillus Calmette-guerin and Mycobacterium tuberculosis infections.Am J Pathol2005
15908396Differential effects of total and partial neutralization of tumor necrosis factor on cell-mediated immunity to Mycobacterium bovis BCG infection.Infect Immun2005
15519650Inhibition of inducible nitric oxide synthase protects against liver injury induced by mycobacterial infection and endotoxins.J Hepatol2004
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Collaborators

Frank Brombacher
University of Cape Town
Co-authored papers 39
Harukazu Suzuki
RIKEN Center for Integrative Medical Sciences
Co-authored papers 19
Sugata Roy
RIKEN Center for Integrative Medical Sciences
Co-authored papers 12
Sebastian Schmeier
Massey University
Co-authored papers 10
Anita Schwegmann
South African Medical Research Council (SAMRC), University of Cape Town
Co-authored papers 6
Yoshihide Hayashizaki
Center for Integrative Medical Sciences
Co-authored papers 6
Hideya Kawaji
RIKEN Center for Integrative Medical Sciences
Co-authored papers 5
Masayoshi Itoh
RIKEN Center for Integrative Medical Sciences
Co-authored papers 5
Erik Arner
RIKEN Center for Integrative Medical Sciences (IMS)
Co-authored papers 5
Tanvir Alam
College of Science and Engineering, Hamad Bin Khalifa University
Co-authored papers 5
Timo Lassmann
Telethon Kids Institute, University of Western Australia
Co-authored papers 5
Piero Carninci
RIKEN Center for Integrative Medical Sciences
Co-authored papers 5
Alistair R R Forrest
RIKEN Center for Integrative Medical Sciences
Co-authored papers 5
Suzana Savvi
South African Medical Research Council (SAMRC), University of Cape Town
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Dave S B Hoon
Saint John's Cancer Institute at Saint John's Health Center
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Carsten O Daub
International Institute of Molecular and Cell Biology in Warsaw
Co-authored papers 3
Sayaka Nagao-Sato
Ochanomizu University
Co-authored papers 3
Robert Passier
University of Twente
Co-authored papers 3
Akira Hasegawa
RIKEN Center for Integrative Medical Sciences
Co-authored papers 3
Beatrice Bodega
University of Milan
Co-authored papers 3
Andreas Lennartsson
Karolinska Institute
Co-authored papers 3
Dan Goldowitz
University of British Columbia
Co-authored papers 3
Michael Detmar
Institute of Pharmaceutical Sciences, ETH Zurich
Co-authored papers 3
Naoto Kondo
Nagoya City University Graduate School of Medical Sciences
Co-authored papers 3
Peter Zhang
Child and Family Research Institute, University of British Columbia
Co-authored papers 3
Haruhiko Koseki
RIKEN Research Center for Allergy and Immunology
Co-authored papers 3
Yosuke Mizuno
Yokohama National University
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Ernst J Wolvetang
Australian Institute for Bioengineering and Nanotechnology, University of Queensland
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Soichi Ogishima
Tohoku University Graduate School of Medicine
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Release 1.2