Author details

Full Name

Hasmik Keshishian

Affiliation

ORCID

Career Start Year

1996

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37171958	Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model.	Cell Rep	2023
35908190	Huntingtin turnover: modulation of huntingtin degradation by cAMP-dependent protein kinase A (PKA) phosphorylation of C-HEAT domain Ser2550.	Hum Mol Genet	2023
37657442	Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice.	Neuron	2023
37794589	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	Cell	2023
37430060	ALK peptide vaccination restores the immunogenicity of ALK-rearranged non-small cell lung cancer.	Nat Cancer	2023
35283288	TAILS Identifies Candidate Substrates and Biomarkers of ADAMTS7, a Therapeutic Protease Target in Coronary Artery Disease.	Mol Cell Proteomics	2022
35471151	A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling.	Elife	2022
34663921	Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer.	Nat Biotechnol	2022
35105861	PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation.	Nat Commun	2022
34391888	Optimized Liquid and Gas Phase Fractionation Increases HLA-Peptidome Coverage for Primary Cell and Tissue Samples.	Mol Cell Proteomics	2021
33349665	The SARS-CoV-2 RNA-protein interactome in infected human cells.	Nat Microbiol	2021
34569154	A highly multiplexed quantitative phosphosite assay for biology and preclinical studies.	Mol Syst Biol	2021
33361193	The conserved translation factor LepA is required for optimal synthesis of a porin family in Mycobacterium smegmatis.	J Bacteriol	2020
31804723	Increased mitochondrial apoptotic priming with targeted therapy predicts clinical response to re-induction chemotherapy.	Am J Hematol	2020
31844290	A large peptidome dataset improves HLA class I epitope prediction across most of the human population.	Nat Biotechnol	2020
32418505	CITED4 Protects Against Adverse Remodeling in Response to Physiological and Pathological Stress.	Circ Res	2020
31043423	Patterns of substrate affinity, competition, and degradation kinetics underlie biological activity of thalidomide analogs.	Blood	2019
29551269	Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis.	Cell	2018
29988108	Reproducible workflow for multiplexed deep-scale proteome and phosphoproteome analysis of tumor tissues by liquid chromatography-mass spectrometry.	Nat Protoc	2018
28183812	New Guidelines for Publication of Manuscripts Describing Development and Application of Targeted Mass Spectrometry Measurements of Peptides and Proteins.	Mol Cell Proteomics	2017
28749931	Quantitative, multiplexed workflow for deep analysis of human blood plasma and biomarker discovery by mass spectrometry.	Nat Protoc	2017
27444932	Aptamer-Based Proteomic Profiling Reveals Novel Candidate Biomarkers and Pathways in Cardiovascular Disease.	Circulation	2016
27321643	Automated Microchromatography Enables Multiplexing of Immunoaffinity Enrichment of Peptides to Greater than 150 for Targeted MS-Based Assays.	Anal Chem	2016
26152395	Quantitative proteomics suggests decrease in the secretogranin-1 cerebrospinal fluid levels during the disease course of multiple sclerosis.	Proteomics	2015
25693799	Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma.	Mol Cell Proteomics	2015
25724909	Multiplexed, Quantitative Workflow for Sensitive Biomarker Discovery in Plasma Yields Novel Candidates for Early Myocardial Injury.	Mol Cell Proteomics	2015
24522978	Simplified and efficient quantification of low-abundance proteins at very high multiplex via targeted mass spectrometry.	Mol Cell Proteomics	2014
24443746	Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach.	Mol Cell Proteomics	2014
23689285	Design, implementation and multisite evaluation of a system suitability protocol for the quantitative assessment of instrument performance in liquid chromatography-multiple reaction monitoring-MS (LC-MRM-MS).	Mol Cell Proteomics	2013
21685905	A pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease.	Nat Biotechnol	2011
20501647	Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.	Mol Cancer Res	2010
20022980	Automated detection of inaccurate and imprecise transitions in peptide quantification by multiple reaction monitoring mass spectrometry.	Clin Chem	2010
19372185	Developing multiplexed assays for troponin I and interleukin-33 in plasma by peptide immunoaffinity enrichment and targeted mass spectrometry.	Clin Chem	2009
19596694	Quantification of cardiovascular biomarkers in patient plasma by targeted mass spectrometry and stable isotope dilution.	Mol Cell Proteomics	2009
19561596	Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma.	Nat Biotechnol	2009
18534968	Accurate inclusion mass screening: a bridge from unbiased discovery to targeted assay development for biomarker verification.	Mol Cell Proteomics	2008
18769631	Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury.	J Clin Invest	2008
17141195	Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop.	Biochemical and Biophysical Research Communications	2007
17939991	Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilution.	Mol Cell Proteomics	2007
9174920	Peptides as affinity surfaces for protein purification.	Journal of Molecular Recognition	1996