Author details

Full Name

Claes Ladenvall

Affiliation

ORCID

Career Start Year

2005

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37580114	Integrating a Polygenic Risk Score into a clinical setting would impact risk predictions in familial breast cancer.	J Med Genet	2024
37440454	Novel pathological variants of NHP2 affect N-terminal domain flexibility, protein stability, H/ACA Ribonucleoprotein (RNP) complex formation and telomerase activity.	Hum Mol Genet	2023
37022349	Somatic Exonic Deletions in RUNX1 Constitutes a Novel Recurrent Genomic Abnormality in Acute Myeloid Leukemia.	Clin Cancer Res	2023
35935605	Five Percent Variant Allele Frequency Is a Reliable Reporting Threshold for <i>TP53</i> Variants Detected by Next Generation Sequencing in Chronic Lymphocytic Leukemia in the Clinical Setting.	Hemasphere	2022
33579170	PD-L1 and IDO1 are potential targets for treatment in patients with primary diffuse large B-cell lymphoma of the CNS.	Acta Oncol	2021
29360107	Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.	Sci Data	2018
29186428	Genome-wide meta-analysis identifies novel determinants of circulating serum progranulin.	Hum Mol Genet	2018
29703844	A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.	Diabetes	2018
27647854	The Genetic Landscape of Renal Complications in Type 1 Diabetes.	J Am Soc Nephrol	2017
28341696	A Low-Frequency Inactivating <i>AKT2</i> Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.	Diabetes	2017
28898252	Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.	PLoS Med	2017
29257133	Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.	Sci Data	2017
26306643	Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research.	Eur J Hum Genet	2016
27155871	Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes.	Diabetologia	2016
27416945	Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci.	Diabetes	2016
27398621	The genetic architecture of type 2 diabetes.	Nature	2016
26395740	Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.	Diabetes	2016
26132169	Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.	PLoS Genet	2015
25712996	Age- and sex-specific causal effects of adiposity on cardiovascular risk factors.	Diabetes	2015
25752315	Measures of atherosclerotic burden are associated with clinically manifest cardiovascular disease in type 2 diabetes: a European cross-sectional study.	Journal of Internal Medicine	2015
25625282	Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.	PLoS Genet	2015
25961943	The impact of low-frequency and rare variants on lipid levels.	Nat Genet	2015
25078778	Distribution and medical impact of loss-of-function variants in the Finnish founder population.	PLoS Genet	2014
25375650	Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets.	PLoS Genetics	2014
25521368	Genome wide meta-analysis highlights the role of genetic variation in RARRES2 in the regulation of circulating serum chemerin.	PLoS Genet	2014
25426837	Age-related clonal hematopoiesis associated with adverse outcomes.	N Engl J Med	2014
24306210	Expression of phosphofructokinase in skeletal muscle is influenced by genetic variation and associated with insulin sensitivity.	Diabetes	2014
25201977	Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism.	Proc Natl Acad Sci U S A	2014
24516404	Chromosome X-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation.	PLoS Genet	2014
23160641	Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.	Diabetologia	2013
23824655	The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis.	PLoS Med	2013
23882023	Network-based analysis of genome wide association data provides novel candidate genes for lipid and lipoprotein traits.	Mol Cell Proteomics	2013
23557703	Effects of common genetic variants associated with type 2 diabetes and glycemic traits on Î±- and Î²-cell function and insulin action in humans.		2013
23583979	Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.	Nat Genet	2013
23028342	New susceptibility loci associated with kidney disease in type 1 diabetes.	PLoS Genet	2012
22939844	Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes.	Molecular and Cellular Endocrinology	2012
22581228	A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.	Nat Genet	2012
22492527	Reduced insulin exocytosis in human pancreatic Î²-cells with gene variants linked to type 2 diabetes.		2012
21325017	Two common genetic variants near nuclear-encoded OXPHOS genes are associated with insulin secretion in vivo.	Eur J Endocrinol	2011
21195351	A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes.	Cell Metab	2011
20185807	Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.	Diabetes	2010
20150578	The association of mitochondrial content with prevalent and incident type 2 diabetes.	J Clin Endocrinol Metab	2010
19061349	Association between factor XIII single nucleotide polymorphisms and aneurysmal subarachnoid hemorrhage.	Journal of Neurosurgery	2009
18331453	Fibrinogen gene variation and ischemic stroke.	Journal of Thrombosis and Haemostasis	2008
17272741	Thrombin activatable fibrinolysis inhibitor activation peptide shows association with all major subtypes of ischemic stroke and with TAFI gene variation.	Arteriosclerosis, Thrombosis, and Vascular Biology	2007
16809555	Serum C-reactive protein concentration and genotype in relation to ischemic stroke subtype.	Stroke	2006
16179568	Fibrinolytic gene polymorphism and ischemic stroke.	Stroke	2005
15933254	Family history in ischemic stroke before 70 years of age: the Sahlgrenska Academy Study on Ischemic Stroke.	Stroke	2005