Author details

Full Name

Laszlo Otvos

Affiliation

ORCID

Career Start Year

1970

Papers

271

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
35223768	Functional Effects of ARV-1502 Analogs Against Bacterial Hsp70 and Implications for Antimicrobial Activity.	Frontiers in Chemistry	2022
35328571	Influence of Substitutions in the Binding Motif of Proline-Rich Antimicrobial Peptide ARV-1502 on 70S Ribosome Binding and Antimicrobial Activity.	International Journal of Molecular Sciences	2022
34276408	Leptin Receptor Blockade Attenuates Hypertension, but Does Not Affect Ventilatory Response to Hypoxia in a Model of Polygenic Obesity.	Frontiers in Physiology	2021
33794502	Leptin antagonism inhibits prostate cancer xenograft growth and progression.		2021
33112829	Adiponectin receptor activation inhibits prostate cancer xenograft growth.		2020
31456747	Potential Adiponectin Receptor Response Modifier Therapeutics.	Frontiers in Endocrinology	2019
31799234	Quantitation of a Novel Engineered Anti-infective Host Defense Peptide, ARV-1502: Pharmacokinetic Study of Different Doses in Rats and Dogs.	Frontiers in Chemistry	2019
30186829	Advantage of a Narrow Spectrum Host Defense (Antimicrobial) Peptide Over a Broad Spectrum Analog in Preclinical Drug Development.	Frontiers in Chemistry	2018
30155456	Synergy Between Proline-Rich Antimicrobial Peptides and Small Molecule Antibiotics Against Selected Gram-Negative Pathogens and .	Frontiers in Chemistry	2018
28154813	The Effect of Selective D- or N-Methyl Arginine Substitution on the Activity of the Proline-Rich Antimicrobial Peptide, Chex1-Arg20.	Frontiers in Chemistry	2017
28667272	Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target.	Scientific Reports	2017
28664267	Transdermally administered proline-arginine-rich host defense peptides show systemic efficacy in a lethal mouse bacteremia model.	Amino Acids	2017
27862429	C-Terminal Modification and Multimerization Increase the Efficacy of a Proline-Rich Antimicrobial Peptide.	Chemistry - A European Journal	2017
28155618	Host Defense Peptides and Cancer; Perspectives on Research Design and Outcomes.	Protein and Peptide Letters	2017
27539330	Immunomodulatory effects of anti-microbial peptides.	Acta Microbiologica et Immunologica Hungarica	2016
26926423	Membrane interactions of proline-rich antimicrobial peptide, Chex1-Arg20, multimers.		2016
26953321	Leptin Induces Hypertension and Endothelial Dysfunction via Aldosterone-Dependent Mechanisms in Obese Female Mice.	Hypertension	2016
26319645	Polyvinyl alcohol nanofiber formulation of the designer antimicrobial peptide APO sterilizes Acinetobacter baumannii-infected skin wounds in mice.	Amino Acids	2016
26243270	Reciprocal Inhibitory Interactions Between the Reward-Related Effects of Leptin and Cocaine.		2016
27878121	Corrigendum: Designer Leptin Receptor Antagonist Allo-aca Inhibits VEGF Effects in Ophthalmic Neoangiogenesis Models.	Front Mol Biosci	2016
27790618	Designer Leptin Receptor Antagonist Allo-aca Inhibits VEGF Effects in Ophthalmic Neoangiogenesis Models.	Front Mol Biosci	2016
26384569	Multimerization of a Proline-Rich Antimicrobial Peptide, Chex-Arg20, Alters Its Mechanism of Interaction with the Escherichia coli Membrane.		2015
25835521	Therapeutic utility of antibacterial peptides in wound healing.	Expert Review of Anti-Infective Therapy	2015
25879324	Molecular targeting of obesity pathways in cancer.	Hormone Molecular Biology and Clinical Investigation	2015
25683126	Optimization of adiponectin-derived peptides for inhibition of cancer cell growth and signaling.	Biopolymers	2015
26138813	Commentary: drugs from bugs.	Current Protein and Peptide Science	2015
26220769	The adipokine leptin mediates muscle- and liver-derived IGF-1 in aged mice.		2015
25152873	Current challenges in peptide-based drug discovery.	Frontiers in Chemistry	2014
25368867	Development of second generation peptides modulating cellular adiponectin receptor responses.	Frontiers in Chemistry	2014
24164271	IMAP 2012: Antimicrobial peptides to combat (multi)drug-resistant pathogens.	Protein and Peptide Letters	2014
24164265	Hydroxyproline substitutions stabilize non-glycosylated drosocin against serum proteases without challenging its antibacterial activity.	Protein and Peptide Letters	2014
24164262	The designer proline-rich antibacterial peptide A3-APO prevents Bacillus anthracis mortality by deactivating bacterial toxins.	Protein and Peptide Letters	2014
24366600	The designer leptin antagonist peptide Allo-aca compensates for short serum half-life with very tight binding to the receptor.	Amino Acids	2014
25141976	Proline-rich antimicrobial peptides: potential therapeutics against antibiotic-resistant bacteria.	Amino Acids	2014
24562631	Designer adiponectin receptor agonist stabilizes metabolic function and prevents brain injury caused by HIV protease inhibitors.	Journal of NeuroImmune Pharmacology	2014
23506735	Leptin and ghrelin prevent hippocampal dysfunction induced by AÎ² oligomers.	Neuroscience	2013
24074727	Rapid systemic and local treatments with the antibacterial peptide dimer A3-APO and its monomeric metabolite eliminate bacteria and reduce inflammation in intradermal lesions infected with Propionibacterium acnes and meticillin-resistant Staphylococcus au	International Journal of Antimicrobial Agents	2013
24098500	Exploring leptin antagonism in ophthalmic cell models.	PLoS One	2013
24014441	Identification of adipokine receptor agonists and turning them to antagonists.	Methods in Molecular Biology	2013
24278025	Killer bee molecules: antimicrobial peptides as effector molecules to target sporogonic stages of Plasmodium.	PLoS Pathogens	2013
23567149	Designer peptide antagonist of the leptin receptor with peripheral antineoplastic activity.	Peptides	2013
22180783	Vaccination with M2e-based multiple antigenic peptides: characterization of the B cell response and protection efficacy in inbred and outbred mice.	PLoS ONE	2011
21353530	Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer.	European Journal of Cancer	2011
21353493	Broad-spectrum antimicrobial efficacy of peptide A3-APO in mouse models of multidrug-resistant wound and lung infections cannot be explained by in vitro activity against the pathogens involved.	International Journal of Antimicrobial Agents	2011
20564029	Intramuscularly administered peptide A3-APO is effective against carbapenem-resistant Acinetobacter baumannii in mouse models of systemic infections.	Biopolymers	2011
20564005	Peptide-based leptin receptor antagonists for cancer treatment and appetite regulation.	Biopolymers	2011
21974986	Design and development of a peptide-based adiponectin receptor agonist for cancer treatment.	BMC Biotechnology	2011
21771332	Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects.	BMC Cancer	2011
21723351	Toward understanding the role of leptin and leptin receptor antagonism in preclinical models of rheumatoid arthritis.	Peptides	2011
21916566	Targeting the leptin receptor: a potential new mode of treatment for breast cancer.	Expert Review of Anticancer Therapy	2011