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Author Details

Jonathan A Pachter
Laufer Center for Physical and Quantitative Biology, Stony Brook University
1979
78
32
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36797947Nonequilibrium statistical physics beyond the ideal heat bath approximation.Phys Rev E2023
37858338High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma.Cell Rep Med2023
37053187Early path dominance as a principle for neurodevelopment.Proc Natl Acad Sci U S A2023
37140091In vivo activity of the dual PI3Kδ and PI3Kγ inhibitor duvelisib against pediatric acute lymphoblastic leukemia xenografts.Pediatr Blood Cancer2023
37071496Duvelisib Eliminates CLL B Cells, Impairs CLL-Supporting Cells, and Overcomes Ibrutinib Resistance in a Xenograft Model.Clin Cancer Res2023
36882482Roles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib.Sci Rep2023
35084470PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity.Blood2022
35467979Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis.Proc Natl Acad Sci U S A2022
35718227Dual Stromal Targeting Sensitizes Pancreatic Adenocarcinoma for Anti-Programmed Cell Death Protein 1 Therapy.Gastroenterology2022
36075300Review of the application of Kirchhoff's Laws of series and parallel flows to pharmacology: Defining organ clearance.Pharmacol Ther2022
34050172FAK inhibition alone or in combination with adjuvant therapies reduces cancer stem cell activity.NPJ Breast Cancer2021
33568347Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for <i>GNAQ</i>-Driven Uveal Melanoma.Clin Cancer Res2021
33786583Synergistic efficacy of the dual PI3K-δ/γ inhibitor duvelisib with the Bcl-2 inhibitor venetoclax in Richter syndrome PDX models.Blood2021
34389658Correction: Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for <i>GNAQ</i>-Driven Uveal Melanoma.Clin Cancer Res2021
31076405Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion.Gut2020
32793908Natural Killer cell activation, reduced ACE2, TMPRSS2, cytokines G-CSF, M-CSF and SARS-CoV-2-S pseudovirus infectivity by MEK inhibitor treatment of human cells.bioRxiv2020
32404407Combinatorial Inhibition of Focal Adhesion Kinase and BCL-2 Enhances Antileukemia Activity of Venetoclax in Acute Myeloid Leukemia.Mol Cancer Ther2020
30342021Evaluating the potential of kinase inhibitors to suppress DNA repair and sensitise ovarian cancer cells to PARP inhibitors.Biochem Pharmacol2019
31478830FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy.Elife2019
30785827Maintenance Defactinib Versus Placebo After First-Line Chemotherapy in Patients With Merlin-Stratified Pleural Mesothelioma: COMMAND-A Double-Blind, Randomized, Phase II Study.J Clin Oncol2019
30655367PYK2/FAK inhibitors reverse hypoxia-induced drug resistance in multiple myeloma.Haematologica2019
28692661The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma.PLoS One2017
28270436Focal Adhesion Kinase as a Potential Target in AML and MDS.Mol Cancer Ther2017
29050315The activation of SRC family kinases and focal adhesion kinase with the loss of the amplified, mutated <i>EGFR</i> gene contributes to the resistance to afatinib, erlotinib and osimertinib in human lung cancer cells.Oncotarget2017
28881682Inhibition of FAK kinase activity preferentially targets cancer stem cells.Oncotarget2017
27376576Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy.Nat Med2016
26387544Targeting PYK2 mediates microenvironment-specific cell death in multiple myeloma.Oncogene2016
27123491Synergism of FAK and tyrosine kinase inhibition in Ph<sup>+</sup> B-ALL.JCI Insight2016
25432176PI3K/mTOR dual inhibitor VS-5584 preferentially targets cancer stem cells.Cancer Res2015
26406376Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity.Cell2015
24371224Tumor suppressor alterations cooperate to drive aggressive mesotheliomas with enriched cancer stem cells via a p53-miR-34a-c-Met axis.Cancer Res2014
25217697Pyk2 promotes tumor progression in multiple myeloma.Blood2014
24848258Merlin deficiency predicts FAK inhibitor sensitivity: a synthetic lethal relationship.Sci Transl Med2014
23317569Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors.Bioorg Med Chem Lett2013
24900721Discovery of novel insulin-like growth factor-1 receptor inhibitors with unique time-dependent binding kinetics.ACS Med Chem Lett2013
23773865Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases.Bioorg Med Chem Lett2013
22942252ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion.Cancer Res2012
21251824Potent and selective cyclohexyl-derived imidazopyrazine insulin-like growth factor 1 receptor inhibitors with in vivo efficacy.Bioorg Med Chem Lett2011
21643654Inducible expression of TGFβ, snail and Zeb1 recapitulates EMT in vitro and in vivo in a NSCLC model.Clin Exp Metastasis2011
21673091Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin.Mol Cancer Ther2011
21353551Imidazo[1,5-a]pyrazines: orally efficacious inhibitors of mTORC1 and mTORC2.Bioorg Med Chem Lett2011
21041998Cooperative signaling between oncostatin M, hepatocyte growth factor and transforming growth factor-β enhances epithelial to mesenchymal transition in lung and pancreatic tumor models.Cells Tissues Organs2011
20124453A fully human insulin-like growth factor-I receptor antibody SCH 717454 (Robatumumab) has antitumor activity as a single agent and in combination with cytotoxics in pediatric tumor xenografts.Mol Cancer Ther2010
24900240Discovery of an Orally Efficacious Imidazo[5,1-f][1,2,4]triazine Dual Inhibitor of IGF-1R and IR.ACS Med Chem Lett2010
20924128Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancer.Mol Cancer Ther2010
19895344High-throughput screening for mTORC1/mTORC2 kinase inhibitors using a chemiluminescence-based ELISA assay.Assay Drug Dev Technol2009
18374184Quantitative high-throughput cell-based assays for inhibitors of ROCK kinases.Methods Enzymol2008
18922904Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors.Cancer Res2008
17671083A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo.Mol Cancer Ther2007
17607936Inhibition of the IGF-I receptor for treatment of cancer. Kinase inhibitors and monoclonal antibodies as alternative approaches.Recent Results Cancer Res2007
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Collaborators

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Co-authored papers 3
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Co-authored papers 3
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Co-authored papers 3
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Co-authored papers 2
Moores Cancer Center, University of California San Diego
Co-authored papers 2
Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine
Co-authored papers 2
Center for Cancer Research, National Cancer Institute
Co-authored papers 2
Thomas Jefferson University
Co-authored papers 2
Sidney Kimmel Cancer Center, Thomas Jefferson University
Co-authored papers 2
Fox Chase Cancer Center
Co-authored papers 2
Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine
Co-authored papers 2
National Cancer Institute
Co-authored papers 2
University of California San Diego
Co-authored papers 2
Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 2
University of California San Diego
Co-authored papers 2
Moores Cancer Center, University of California San Diego
Co-authored papers 2
Moores Cancer Center, University of California San Diego
Co-authored papers 2
Livestrong Cancer Institutes, Dell Medical School, University of Texas at Austin
Co-authored papers 2
The University of Texas Health Science Center at San Antonio
Co-authored papers 2
Thomas Jefferson University
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University of California San Diego Health
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
Moores Cancer Center, University of California San Diego
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Johns Hopkins University School of Medicine
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University of Leicester
Co-authored papers 1