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Author Details

Neil P Shah
University of California San Francisco
1985
127
63
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37246588Treatment-free remission after dasatinib in patients with chronic myeloid leukaemia in chronic phase with deep molecular response: Final 5-year analysis of DASFREE.Br J Haematol2023
37895201Complex Genomic Rearrangements Involving <i>ETV6</i>::<i>ABL1</i> Gene Fusion in an Individual with Myeloid Neoplasm.Genes (Basel)2023
34491344Patient-Reported Functional Outcomes in Patients With Chronic Myeloid Leukemia After Stopping Tyrosine Kinase Inhibitors.J Natl Cancer Inst2022
35511672Patient- and physician-reported pain after tyrosine kinase inhibitor discontinuation among patients with chronic myeloid leukemia.Haematologica2022
36054756Ponatinib after failure of second-generation tyrosine kinase inhibitor in resistant chronic-phase chronic myeloid leukemia.Am J Hematol2022
32414851Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models.Haematologica2021
33626861The <i>EBF1-PDGFRB</i> T681I mutation is highly resistant to imatinib and dasatinib <i>in vitro</i> and detectable in clinical samples prior to treatment.Haematologica2021
34479037Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor.Eur J Med Chem2021
34103301Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia.Clin Cancer Res2021
33180106Assessment of Outcomes After Stopping Tyrosine Kinase Inhibitors Among Patients With Chronic Myeloid Leukemia: A Nonrandomized Clinical Trial.JAMA Oncol2021
33022644Chronic Myeloid Leukemia, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.J Natl Compr Canc Netw2020
31647335Dasatinib discontinuation in patients with chronic-phase chronic myeloid leukemia and stable deep molecular response: the DASFREE study.Leuk Lymphoma2020
31088841Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia.Cancer Discov2019
30093398Incidence, outcomes, and risk factors of pleural effusion in patients receiving dasatinib therapy for Philadelphia chromosome-positive leukemia.Haematologica2019
31270078ATP-Competitive Inhibitors Midostaurin and Avapritinib Have Distinct Resistance Profiles in Exon 17-Mutant KIT.Cancer Res2019
31117031NCCN Guidelines Updates: Discontinuing TKI Therapy in the Treatment of Chronic Myeloid Leukemia.J Natl Compr Canc Netw2019
29206554Front-Line Treatment Options for Chronic-Phase Chronic Myeloid Leukemia.J Clin Oncol2018
29859851Quizartinib, an FLT3 inhibitor, as monotherapy in patients with relapsed or refractory acute myeloid leukaemia: an open-label, multicentre, single-arm, phase 2 trial.Lancet Oncol2018
30181422Chronic Myeloid Leukemia, Version 1.2019, NCCN Clinical Practice Guidelines in Oncology.J Natl Compr Canc Netw2018
29609532Design and rationale for the life after stopping tyrosine kinase inhibitors (LAST) study, a prospective, single-group longitudinal study in patients with chronic myeloid leukemia.BMC Cancer2018
29567798Ponatinib efficacy and safety in Philadelphia chromosome-positive leukemia: final 5-year results of the phase 2 PACE trial.Blood2018
29487300Rational Design, Synthesis and Biological Evaluation of Pyrimidine-4,6-diamine derivatives as Type-II inhibitors of FLT3 Selective Against c-KIT.Sci Rep2018
27890928Identification and characterization of activating ABL1 1b kinase mutations: impact on sensitivity to ATP-competitive and allosteric ABL1 inhibitors.Leukemia2017
28490572Heterogeneous resistance to quizartinib in acute myeloid leukemia revealed by single-cell analysis.Blood2017
28534184Evaluation of cardiovascular ischemic event rates in dasatinib-treated patients using standardized incidence ratios.Ann Hematol2017
28667329Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells.Sci Rep2017
26998677Lymphocytosis after treatment with dasatinib in chronic myeloid leukemia: Effects on response and toxicity.Cancer2016
26603839Compound mutations in BCR-ABL1 are not major drivers of primary or secondary resistance to ponatinib in CP-CML patients.Blood2016
26511402Novel TKI-resistant BCR-ABL1 gatekeeper residue mutations retain in vitro sensitivity to axitinib.Leukemia2016
26585411Quizartinib elicits differential responses that correlate with karyotype and genotype of the leukemic clone.Leukemia2016
27956535NCCN Guidelines Insights: Chronic Myeloid Leukemia, Version 1.2017.J Natl Compr Canc Netw2016
27192969Dasatinib in imatinib-resistant or -intolerant chronic-phase, chronic myeloid leukemia patients: 7-year follow-up of study CA180-034.Am J Hematol2016
27217448Final 5-Year Study Results of DASISION: The Dasatinib Versus Imatinib Study in Treatment-Naïve Chronic Myeloid Leukemia Patients Trial.J Clin Oncol2016
27158668The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia.JCI Insight2016
26686247Low incidence of peripheral arterial disease in patients receiving dasatinib in clinical trials.Leukemia2016
27083332Ponatinib versus imatinib for newly diagnosed chronic myeloid leukaemia: an international, randomised, open-label, phase 3 trial.Lancet Oncol2016
25765758Computer aided drug discovery of highly ligand efficient, low molecular weight imidazopyridine analogs as FLT3 inhibitors.Eur J Med Chem2015
26461088PPARγ: Welcoming the New Kid on the CML Stem Cell Block.Cancer Cell2015
26419724Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance.Sci Rep2015
26284693Clinical features of pulmonary arterial hypertension in patients receiving dasatinib.Am J Hematol2015
26108694FLT3 D835 mutations confer differential resistance to type II FLT3 inhibitors.Leukemia2015
25870379Historical views, conventional approaches, and evolving management strategies for myeloproliferative neoplasms.J Natl Compr Canc Netw2015
25847190Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397.Cancer Discov2015
24131888Implications of BCR-ABL1 kinase domain-mediated resistance in chronic myeloid leukemia.Leuk Res2014
25768408Integrating current treatment options for TKI-resistant chronic myeloid leukemia.Clin Adv Hematol Oncol2014
25456130Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis.Cell Rep2014
25531068Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy.Elife2014
25361806Chronic myelogenous leukemia, version 1.2015.J Natl Compr Canc Netw2014
25166742Sensitive and selective plasmon ruler nanosensors for monitoring the apoptotic drug response in leukemia.ACS Nano2014
24584101Dual kinase-bromodomain inhibitors for rationally designed polypharmacology.Nat Chem Biol2014
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Collaborators

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Co-authored papers 27
Georgia Cancer Center
Co-authored papers 27
University of California San Francisco
Co-authored papers 22
University of Utah Huntsman Cancer Institute
Co-authored papers 20
Memorial Sloan Kettering Cancer Center
Co-authored papers 16
Fred Hutchinson Cancer Center
Co-authored papers 16
University of Michigan Rogel Cancer Center.
Co-authored papers 12
University of California san francisco
Co-authored papers 10
Dana-Farber Cancer Institute
Co-authored papers 10
Yonsei University College of Medicine, Republic of Korea S. Biomedics Co.
Co-authored papers 9
Stanford University School of Medicine
Co-authored papers 8
Fred Hutchinson Cancer Center.
Co-authored papers 8
University of California san francisco
Co-authored papers 6
University of California berkeley
Co-authored papers 5
Oregon Health & Science University
Co-authored papers 4
Novant Health Cancer Institute - Elizabeth
Co-authored papers 4
David Geffen School of Medicine at university of california los angeles
Co-authored papers 4
University of California san francisco
Co-authored papers 4
Center for Health Measurement, Duke University
Co-authored papers 4
University of California San Francisco
Co-authored papers 3
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
Co-authored papers 3
Institut de Recherche Saint-Louis, Universite de Paris
Co-authored papers 3
Schools of Pharmacy and Medicine, University of California san francisco
Co-authored papers 3
University of Alabama at Birmingham
Co-authored papers 3
University of Washington
Co-authored papers 2
St Jude Children's Research Hospital
Co-authored papers 2
Washington University School of Medicine
Co-authored papers 2
Instituto de Salud Carlos III
Co-authored papers 2
Benioff Children's Hospitals, University of California san francisco
Co-authored papers 2
St Jude Children's Research Hospital
Co-authored papers 2