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Author Details

David G Lambright
University of Massachusetts Medical School
1985
84
44
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
34358462Propelling COPII vesicle biogenesis at the endoplasmic reticulum.Structure2021
34646016Systems-level effects of allosteric perturbations to a model molecular switch.Nature2021
34453708High-Throughput Assay for Profiling the Substrate Specificity of Rab GTPase-Activating Proteins.Methods Mol Biol2021
32268075X Caps the Phosphate for Phospho-Rab GTPase Recognition in Ciliogenesis and Parkinson's Disease.Structure2020
33026967Coordination of Grp1 recruitment mechanisms by its phosphorylation.Mol Biol Cell2020
30620905TRAPPing a Rab GTPase by the Tail.Dev Cell2019
31601460Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes.Structure2019
31084567ARF GTPases and their GEFs and GAPs: concepts and challenges.Mol Biol Cell2019
29276036Structural Dynamics Control Allosteric Activation of Cytohesin Family Arf GTPase Exchange Factors.Structure2018
26972107Invited review: Small GTPases and their GAPs.Biopolymers2016
27880519Special Issue: GTPases in trafficking, autophagy, and disease (FASEB SRC).Small GTPases2016
27780062Membrane Trafficking: An Endosome Tether Meets a Rab and Collapses.Curr Biol2016
25367362Molecular insights into Rab7-mediated endosomal recruitment of core retromer: deciphering the role of Vps26 and Vps35.Traffic2015
26306089Methods for analysis of size-exclusion chromatography-small-angle X-ray scattering and reconstruction of protein scattering.J Appl Crystallogr2015
26536378A PH Domain with Dual Phospholipid Binding Sites Regulates the ARF GAP, ASAP1.Structure2015
25800831High-throughput assay for profiling the substrate specificity of Rab GTPase-activating proteins.Methods Mol Biol2015
24530282Structural basis for PI(4)P-specific membrane recruitment of the Legionella pneumophila effector DrrA/SidM.Structure2014
25233840Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking.Orphanet J Rare Dis2014
25023514Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase β and regulates complex V activity.J Cell Biol2014
24992562The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins.PLoS Pathog2014
23802536Germline mutations affecting Gα11 in hypoparathyroidism.N Engl J Med2013
23821544The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism.J Biol Chem2013
23940353Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors.Proc Natl Acad Sci U S A2013
22308388Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosis.Proc Natl Acad Sci U S A2012
23045393The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes.Mol Cell Biol2012
22762500TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes.Traffic2012
22609160Grp1 plays a key role in linking insulin signaling to glut4 recycling.Dev Cell2012
22637480RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36.J Biol Chem2012
21808068RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins.J Biol Chem2011
20331534The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility.Traffic2010
20534488Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1).Proc Natl Acad Sci U S A2010
20466531Rab GEFs and GAPs.Curr Opin Cell Biol2010
20462958TBC-2 regulates RAB-5/RAB-7-mediated endosomal trafficking in Caenorhabditis elegans.Mol Biol Cell2010
20527794Specificity and membrane partitioning of Grsp1 signaling complexes with Grp1 family Arf exchange factors.Biochemistry2010
20587420A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes.J Biol Chem2010
19522756Structural mechanisms for regulation of membrane traffic by rab GTPases.Traffic2009
18827013Sorting of EGF and transferrin at the plasma membrane and by cargo-specific signaling to EEA1-enriched endosomes.J Cell Sci2008
17233583Evolutionarily conserved structural and functional roles of the FYVE domain.Biochem Soc Symp2007
17901050TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication.J Biol Chem2007
17952054Legionella pneumophila proteins that regulate Rab1 membrane cycling.Nature2007
18042453Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors.Mol Cell2007
17704259Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes.Proc Natl Acad Sci U S A2007
17762880An endocytic pathway as a target of tubby for regulation of fat storage.EMBO Rep2007
17450153Structural basis for Rab GTPase activation by VPS9 domain exchange factors.Nat Struct Mol Biol2007
16615903ESCRT complexes assembled and GLUEd.Structure2006
17007872Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomes.J Mol Biol2006
16807090Membrane and juxtamembrane targeting by PH and PTB domains.Biochim Biophys Acta2006
16906144The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor.Nat Cell Biol2006
16873553The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis.Proc Natl Acad Sci U S A2006
16931513ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose).J Biol Chem2006
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Collaborators

Co-authored papers 8
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Co-authored papers 3
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Co-authored papers 1
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 1
Quantitative Biosciences Institute (QBI), University of California san francisco
Co-authored papers 1
Indian Institute of Science
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Co-authored papers 1
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Co-authored papers 1
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Stanford University School of Medicine
Co-authored papers 1
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Co-authored papers 1
Broad Institute of MIT and Harvard
Co-authored papers 1
J. David Gladstone Institutes
Co-authored papers 1
Columbia University
Co-authored papers 1
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Massachusetts General Hospital
Co-authored papers 1
University of Massachusetts Chan Medical School
Co-authored papers 1
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University of California, USA Quantitative Biosciences Institute san francisco
Co-authored papers 1
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University of California San Francisco
Co-authored papers 1
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Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
J. David Gladstone Institutes
Co-authored papers 1
University of California san francisco
Co-authored papers 1