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Author Details

David W Andrews
Sunnybrook Research Institute, University of Toronto
1978
175
56
PMIDPaper TitleJournal TitlePublished Year
36603764Endoplasmic reticulum protein BIK binds to and inhibits mitochondria-localized antiapoptotic proteins.J Biol Chem2023
34750538Bcl-xL acts as an inhibitor of IP<sub>3</sub>R channels, thereby antagonizing Ca<sup>2+</sup>-driven apoptosis.Cell Death Differ2022
35442739Efficacy and specificity of inhibitors of BCL-2 family protein interactions assessed by affinity measurements in live cells.Sci Adv2022
35245452The case for brakes: Why restrain the size of Bax and Bak pores in outer mitochondrial membranes?Mol Cell2022
35244724The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase.Nucleic Acids Res2022
32665698The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma.Leukemia2021
33617523Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning.PLoS Comput Biol2021
34188192MYC protein interactors in gene transcription and cancer.Nat Rev Cancer2021
33939407Pharmacological Targeting of Executioner Proteins: Controlling Life and Death.J Med Chem2021
34101209An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial␣membrane.EMBO J2021
33162554Neuronal cell life, death, and axonal degeneration as regulated by the BCL-2 family proteins.Cell Death Differ2021
32203069A pilot window-of-opportunity study of preoperative fluvastatin in localized prostate cancer.Prostate Cancer Prostatic Dis2020
32001105Allosteric Regulation of BH3 Proteins in Bcl-x<sub>L</sub> Complexes Enables Switch-like Activation of Bax.Mol Cell2020
31976859The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells.Elife2020
32943617BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models.Cell Death Dis2020
30536013Rapid Imaging of BCL-2 Family Interactions in Live Cells Using FLIM-FRET.Methods Mol Biol2019
33654902Measuring Small-molecule Inhibition of Protein Interactions in Live Cells Using FLIM-FRET.Bio Protoc2019
31711414Genome-wide analysis of Homo sapiens, Arabidopsis thaliana, and Saccharomyces cerevisiae reveals novel attributes of tail-anchored membrane proteins.BMC Genomics2019
31510548Cross-talk reduction in a multiplexed synchroscan streak camera with simultaneous calibration.Opt Express2019
30860026Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2.Elife2019
30521026An RK/ST C-Terminal Motif is Required for Targeting of OEP7.2 and a Subset of Other Arabidopsis Tail-Anchored Proteins to the Plastid Outer Envelope Membrane.Plant Cell Physiol2019
29149100BCL-2 family proteins: changing partners in the dance towards death.Cell Death Differ2018
29987135Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance.EMBO Rep2018
30088945Improved IRE1 and PERK Pathway Sensors for Multiplex Endoplasmic Reticulum Stress Assay Reveal Stress Response to Nuclear Dyes Used for Image Segmentation.Assay Drug Dev Technol2018
29845714miRNA-106a and prostate cancer radioresistance: a novel role for LITAF in ATM regulation.Mol Oncol2018
30485364Peak emission wavelength and fluorescence lifetime are coupled in far-red, GFP-like fluorescent proteins.PLoS One2018
30510014Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove.Cancer Discov2018
28392146A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection.Cell Chem Biol2017
27108441Using Förster-Resonance Energy Transfer to Measure Protein Interactions Between Bcl-2 Family Proteins on Mitochondrial Membranes.Methods Mol Biol2016
27297795High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells.Blood2016
27381287Conformational Heterogeneity of Bax Helix 9 Dimer for Apoptotic Pore Formation.Sci Rep2016
27579615Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells.Oncotarget2016
27569209Evidence Implicating Immunological Host Effects in the Efficacy of Metronomic Low-Dose Chemotherapy.Cancer Res2016
26916338Small molecules reveal an alternative mechanism of Bax activation.Biochem J2016
26702098BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes.EMBO J2016
26896396Lipid Droplet-Associated Proteins (LDAPs) Are Required for the Dynamic Regulation of Neutral Lipid Compartmentation in Plant Cells.Plant Physiol2016
26813996TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL.Sci Rep2016
25236395Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.Cell Death Differ2015
26504625High-speed multifocal array scanning using refractive window tilting.Biomed Opt Express2015
26422066A Versatile Cell Death Screening Assay Using Dye-Stained Cells and Multivariate Image Analysis.Assay Drug Dev Technol2015
25838396Molecular Pathways: Leveraging the BCL-2 Interactome to Kill Cancer Cells--Mitochondrial Outer Membrane Permeabilization and Beyond.Clin Cancer Res2015
25907892Tunable hydrogel thin films from reactive synthetic polymers as potential two-dimensional cell scaffolds.Langmuir2015
25631031The use of FLIM-FRET for the detection of mitochondria-associated protein interactions.Methods Mol Biol2015
256716735-aminolevulinic acid for quantitative seek-and-treat of high-grade dysplasia in Barrett's esophagus cellular models.J Biomed Opt2015
25714678Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax.Biochem J2015
257903435-Aminolevulinic acid induced protoporphyrin IX as a fluorescence marker for quantitative image analysis of high-grade dysplasia in Barrett's esophagus cellular models.J Biomed Opt2015
25536231The relative biological effectiveness of low-dose mammography quality X rays in the human breast MCF-10A cell line.Radiat Res2015
24413197The apoptotic pore on mitochondria: are we breaking through or still stuck?Cell Death Differ2014
25459877Pores of no return.Mol Cell2014
25237314New insights into the targeting of a subset of tail-anchored proteins to the outer mitochondrial membrane.Front Plant Sci2014
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Collaborators

University of Toronto
Co-authored papers 11
University of California san francisco
Co-authored papers 5
Sunnybrook Research Institute
Co-authored papers 5
University of Alberta
Co-authored papers 4
Co-authored papers 3
The Scripps Research Institute, University of California
Co-authored papers 2
University of Toronto
Co-authored papers 2
Co-authored papers 2
University of Toronto
Co-authored papers 2
Princess Margaret Cancer Centre, University Health Network, College St
Co-authored papers 2
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 2
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 2
Princess Margaret Cancer Centre, University Health Network, College St
Co-authored papers 2
Co-authored papers 2
Linkoping University
Co-authored papers 2
New York University Cancer Institute, New York University School of Medicine
Co-authored papers 2
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 2
Oncode Institute
Co-authored papers 2
University Health Network
Co-authored papers 1
University of Alberta
Co-authored papers 1
University of Rome Tor Vergata
Co-authored papers 1
Co-authored papers 1
Baylor College of Medicine
Co-authored papers 1
University of St Andrews
Co-authored papers 1
Evaluative Clinical Sciences, Sunnybrook Research Institute
Co-authored papers 1
Columbia University Irving Medical Center, New York-Presbyterian Hospital
Co-authored papers 1
Sunnybrook Research Institute
Co-authored papers 1
Harvard Medical School
Co-authored papers 1
University of California San Diego
Co-authored papers 1
Co-authored papers 1