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Author Details

Reisa A Sperling
Brigham and Women's Hospital, Massachusetts General Hospital
1992
464
114
PMIDPaper TitleJournal TitlePublished Year
37971861Increased intraindividual variability in reaction time performance is associated with emerging cognitive decline in cognitively unimpaired adults.Neuropsychology2024
37991080Early Detection of Amyloid-Related Changes in Memory among Cognitively Unimpaired Older Adults with Daily Digital Testing.Ann Neurol2024
37830926Eligibility Rates among Racially and Ethnically Diverse US Participants in Phase 2 and Phase 3 Placebo-Controlled, Double-Blind, Randomized Trials of Lecanemab and Elenbecestat in Early Alzheimer Disease.Ann Neurol2024
37932961Plasma Aβ42/Aβ40 and phospho-tau217 concentration ratios increase the accuracy of amyloid PET classification in preclinical Alzheimer's disease.Alzheimers Dement2024
38038976Relationships of Cognitive Measures with Cerebrospinal Fluid but Not Imaging Biomarkers of Alzheimer Disease Vary between Black and White Individuals.Ann Neurol2024
37728659Contribution of extracerebral tracer retention and partial volume effects to sex differences in Flortaucipir-PET signal.J Cereb Blood Flow Metab2024
37971862Capturing learning curves with the multiday Boston Remote Assessment of Neurocognitive Health (BRANCH): Feasibility, reliability, and validity.Neuropsychology2024
35298083Waning locus coeruleus integrity precedes cortical tau accrual in preclinical autosomal dominant Alzheimer's disease.Alzheimers Dement2023
37968130Association of Pathologic and Volumetric Biomarker Changes With Cognitive Decline in Clinically Normal Adults.Neurology2023
37528163Cortical microstructural changes predict tau accumulation and episodic memory decline in older adults harboring amyloid.Commun Med (Lond)2023
37491329Association of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease.Neurology2023
38012286Tangles, not TANGO: targeting tau aggregates.Nat Aging2023
37899618Editorial: Are We There Yet (and How Do We Get There⿦)?J Prev Alzheimers Dis2023
37848035Accelerating Alzheimer's therapeutic development: The past and future of clinical trials.Cell2023
37843849Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease.JAMA Neurol2023
38036535Cell-type-specific Alzheimer's disease polygenic risk scores are associated with distinct disease processes in Alzheimer's disease.Nat Commun2023
35862098Harmonizing the preclinical Alzheimer cognitive composite for multicohort studies.Neuropsychology2023
37458272Trial of Solanezumab in Preclinical Alzheimer's Disease.N Engl J Med2023
37291760Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease.Aging Cell2023
36993271Novel <i>CYP1B1-RMDN2</i> Alzheimer's disease locus identified by genome-wide association analysis of cerebral tau deposition on PET.medRxiv2023
36950699Computerized cognitive practice effects in relation to amyloid and tau in preclinical Alzheimer's disease: Results from a multi-site cohort.Alzheimers Dement (Amst)2023
37218387Subjective cognitive decline across ethnoracial groups in the A4 study.Alzheimers Dement2023
37188781Resilience to autosomal dominant Alzheimer's disease in a Reelin-COLBOS heterozygous man.Nat Med2023
37020050Ultra-high field imaging, plasma markers and autopsy data uncover a specific rostral locus coeruleus vulnerability to hyperphosphorylated tau.Mol Psychiatry2023
37212093Associations of the Harvard Automated Phone Task and Alzheimer's Disease Pathology in Cognitively Normal Older Adults: Preliminary Findings.J Alzheimers Dis2023
37182868Association of Alcohol Consumption with Cognition in Older Population: The A4 Study.J Alzheimers Dis2023
37010830Association of Age at Menopause and Hormone Therapy Use With Tau and β-Amyloid Positron Emission Tomography.JAMA Neurol2023
37276136Linking self-perceived cognitive functioning questionnaires using item response theory: The subjective cognitive decline initiative.Neuropsychology2023
37304049Relation of modifiable lifestyle and mood factors to cognitive concerns among participants and their study partners in the A4 screen data.Alzheimers Dement (Amst)2023
37333223Cell-type-specific Alzheimer's disease polygenic risk scores are associated with distinct disease processes in Alzheimer's disease.medRxiv2023
36710683Evaluation of Blood-Based Plasma Biomarkers as Potential Markers of Amyloid Burden in Preclinical Alzheimer's Disease.J Alzheimers Dis2023
36571821Plasma p-tau217 predicts in vivo brain pathology and cognition in autosomal dominant Alzheimer's disease.Alzheimers Dement2023
36597122APOE effects on regional tau in preclinical Alzheimer's disease.Mol Neurodegener2023
35971310The AHEAD 3-45 Study: Design of a prevention trial for Alzheimer's disease.Alzheimers Dement2023
35962782Tau positron emission tomography in preclinical Alzheimer's disease.Brain2023
34160128Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults.Alzheimers Dement2022
35841244Subjective Cognitive Decline in a Registry Sample: Relation to Psychiatric History, Loneliness, and Personality.J Prev Alzheimers Dis2022
35380901Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer's disease.Proc Natl Acad Sci U S A2022
35440022Meaningful benefits: a framework to assess disease-modifying therapies in preclinical and early Alzheimer's disease.Alzheimers Res Ther2022
35838824Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer's dementia.Acta Neuropathol2022
35473760Association of β-Amyloid and Vascular Risk on Longitudinal Patterns of Brain Atrophy.Neurology2022
35471588Menopause Status Moderates Sex Differences in Tau Burden: A Framingham PET Study.Ann Neurol2022
35470142Predicting Amyloid Positivity in Cognitively Unimpaired Older Adults: A Machine Learning Approach Using A4 Data.Neurology2022
35435938Divergent Cortical Tau Positron Emission Tomography Patterns Among Patients With Preclinical Alzheimer Disease.JAMA Neurol2022
35670654Progressive White Matter Injury in Preclinical Dutch Cerebral Amyloid Angiopathy.Ann Neurol2022
35821672Physical activity is associated with increased resting-state functional connectivity in networks predictive of cognitive decline in clinically unimpaired older adults.Alzheimers Dement (Amst)2022
35552371Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease.Brain2022
35908251The Alzheimer's Association appropriate use recommendations for blood biomarkers in Alzheimer's disease.Alzheimers Dement2022
35907254Association of Elevated Amyloid and Tau Positron Emission Tomography Signal With Near-Term Development of Alzheimer Disease Symptoms in Older Adults Without Cognitive Impairment.JAMA Neurol2022
35871328Association of Carotid Intima Media Thickening with Future Brain Region Specific Amyloid-β Burden.J Alzheimers Dis2022
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Collaborators

Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School
Co-authored papers 225
Massachusetts General Hospital, Harvard Medical School
Co-authored papers 78
Alzheimer's Therapeutic Research Institute, University of Southern California
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Butler Hospital, and Warren Alpert Medical School of Brown University
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Washington University School of Medicine
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UK Dementia Research Institute, University College London
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Maastricht University
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University of California San Francisco
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Harvard Medical School, Massachusetts General Hospital
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Alzheimer's Therapeutic Research Institute, University of Southern California
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Massachusetts General Hospital, the Gordon Center for Medical Imaging
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Massachusetts General Hospital, the Gordon Center for Medical Imaging
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University of New South Wales
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Mayo Clinic Rochester
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Johns Hopkins University School of Medicine
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Rush University Medical Center
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Washington University St. Louis
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Indiana University School of Medicine
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Massachusetts General Hospital
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Icahn School of Medicine at Mount Sinai
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Mallinckrodt Institute of Radiology, Washington University School of Medicine
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New York University.
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Banner Alzheimer's Institute
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Washington University School of Medicine
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Beijing Normal University
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Columbia University Medical Center
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