Author details

Full Name

Richard J Ulevitch

Affiliation

ORCID

Career Start Year

1973

Papers

213

H Index

102

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
35283329	CD14 blockade to prevent ischemic injury to donor organs.	Transplant Immunology	2022
34678072	NLRC4 inflammasome-dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice.	Science advances	2021
33723037	Immunoediting role for major vault protein in apoptotic signaling induced by bacterial <i>N</i>-acyl homoserine lactones.	Proc Natl Acad Sci U S A	2021
32574958	Targeting innate immunity by blocking CD14: Novel approach to control inflammation and organ dysfunction in COVID-19 illness.	eBioMedicine	2020
28267733	US immigration order strikes against biotech.	Nat Biotechnol	2017
28652394	Lack of Both Nucleotide-Binding Oligomerization Domain-Containing Proteins 1 and 2 Primes T Cells for Activation-Induced Cell Death.	Journal of Immunology	2017
26642356	NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component.	Nature Immunology	2016
24591200	Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids.	Innate Immun	2015
23517377	Facilitating cytokine-mediated cancer cell death by proteobacterial N-acylhomoserine lactones.	ACS Chemical Biology	2013
22492977	The costimulatory immunogen LPS induces the B-Cell clones that infiltrate transplanted human kidneys.	Proceedings of the National Academy of Sciences of the United States of America	2012
22300658	The use of small molecule probes to study spatially separated stimulus-induced signaling pathways.	Bioorganic and Medicinal Chemistry Letters	2012
21031309	Modulation of mammalian cell processes by bacterial quorum sensing molecules.	Methods in Molecular Biology	2011
20124104	Nod1 and nod2 are expressed in human and murine renal tubular epithelial cells and participate in renal ischemia reperfusion injury.	Journal of Immunology	2010
20962258	An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury.	Journal of Immunology	2010
18566250	Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule.	Science	2008
18304641	The quorum quenching antibody RS2-1G9 protects macrophages from the cytotoxic effects of the Pseudomonas aeruginosa quorum sensing signalling molecule N-3-oxo-dodecanoyl-homoserine lactone.	Molecular Immunology	2008
17186025	Regulation of Nod1-mediated signaling pathways.	Cell Death and Differentiation	2007
17420470	SGT1 is essential for Nod1 activation.	Proceedings of the National Academy of Sciences of the United States of America	2007
17947685	TLR4/MD-2 monoclonal antibody therapy affords protection in experimental models of septic shock.	Journal of Immunology	2007
17403772	MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3.	Journal of Leukocyte Biology	2007
17301240	Cleavage of p65/RelA of the NF-kappaB pathway by Chlamydia.	Proceedings of the National Academy of Sciences of the United States of America	2007
17961824	Infection control by antibody disruption of bacterial quorum sensing signaling.		2007
17337451	The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis.	Journal of Biological Chemistry	2007
16518575	TLR2 is required for the altered transcription of p75NGF receptors in gram positive infection.	Neurochemical Research	2006
16625199	Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice.	Nature	2006
16552041	NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway.	Infection and Immunity	2006
16446438	Nod1-dependent control of tumor growth.	Proceedings of the National Academy of Sciences of the United States of America	2006
16893899	N-(3-oxo-acyl)homoserine lactones signal cell activation through a mechanism distinct from the canonical pathogen-associated molecular pattern recognition receptor pathways.	J Biol Chem	2006
16479018	Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4.	J Lipid Res	2006
16369559	Limiting inflammatory responses during activation of innate immunity.	Nature Immunology	2005
15879143	A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease.	Journal of Immunology	2005
15229470	Therapeutics targeting the innate immune system.	Nature Reviews Immunology	2004
15576198	Innate immune responses during infection.	Vaccine	2004
15085193	Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure.	Journal of Clinical Investigation	2004
14570885	Structure-activity relationship of synthetic toll-like receptor 4 agonists.	Journal of Biological Chemistry	2004
15107846	Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors.	Nature Immunology	2004
14633627	MKK3 mitogen-activated protein kinase pathway mediates carbon monoxide-induced protection against oxidant-induced lung injury.	American Journal of Pathology	2003
12736252	IKKi/IKKepsilon plays a key role in integrating signals induced by pro-inflammatory stimuli.	Journal of Biological Chemistry	2003
12792851	Regulation of receptor-dependent activation of the innate immune response.	Journal of Infectious Diseases	2003
12960260	How we detect microbes and respond to them: the Toll-like receptors and their transducers.	Journal of Leukocyte Biology	2003
12048196	ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis.	Journal of Biological Chemistry	2002
11706042	MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor.	Journal of Biological Chemistry	2002
11867692	Toll-like receptor 9 mediates CpG-DNA signaling.	Journal of Leukocyte Biology	2002
11865055	IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition.	Molecular and Cellular Biology	2002
11994481	Two msbB genes encoding maximal acylation of lipid A are required for invasive Shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epithelium.	Journal of Immunology	2002
11847341	MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.	Science	2002
11342437	Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1.	Blood	2001
11753214	Blockade of CD14 aggravates experimental shigellosis.		2001
11445729	Clinical expert round table discussion (session 1) at the Margaux Conference on Critical Illness: innate immunity: host recognition of and sensitivity to bacterial components.	Crit Care Med	2001
11445726	New therapeutic targets revealed through investigations of innate immunity.	Critical Care Medicine	2001