Author details

Full Name

Jorge Ferrer

Affiliation

ORCID

Career Start Year

1990

Papers

126

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37066790	Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension.		2023
37028408	Matters arising: Insufficient evidence that pancreatic Î² cells are derived from adult ductal Neurog3-expressing progenitors.	Cell Stem Cell	2023
36759540	Pancreatic microexons regulate islet function and glucose homeostasis.		2023
37261910	Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn's disease, and celiac disease.	JCI Insight	2023
35247892	Concurrent Activation of Kras and Canonical Wnt Signaling Induces Premalignant Lesions That Progress to Extrahepatic Biliary Cancer in Mice.	Cancer Research	2022
35998583	Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster.	Dev Cell	2022
35551307	Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.	Nat Genet	2022
36202974	The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A.	Nat Cell Biol	2022
35483445	Loss of Arid1a and Pten in Pancreatic Ductal Cells Induces Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway.	Gastroenterology	2022
36482255	Current challenges in understanding the role of enhancers in disease.		2022
34644572	TIGER: The gene expression regulatory variation landscape of human pancreatic islets.	Cell Rep	2021
33852861	Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene.	Cell Rep	2021
34282714	-CreER causes efficient recombination of a Rosa26-RFP reporter in duct and islet Î´ cells.	Islets	2021
33893274	CRISPR-based genome editing in primary human pancreatic islet cells.	Nat Commun	2021
34385258	REST is a major negative regulator of endocrine differentiation during pancreas organogenesis.	Genes and Development	2021
32154941	HNF1A recruits KDM6A to activate differentiated acinar cell programs that suppress pancreatic cancer.	EMBO J	2020
32066957	Retraction Note: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice.	Nat Biotechnol	2020
32296036	SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation.	Signal Transduct Target Ther	2020
30892142	The Transcription Factor ERG Regulates Super-Enhancers Associated With an Endothelial-Specific Gene Expression Program.	Circulation Research	2019
30527956	Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.	Lancet Respir Med	2019
31253982	Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes.	Nat Genet	2019
29358691	Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.	Nat Commun	2018
30459811	Long Non-coding RNAs as Local Regulators of Pancreatic Islet Transcription Factor Genes.	Frontiers in Genetics	2018
29864031	Neuronatin regulates pancreatic Î² cell insulin content and secretion.	Journal of Clinical Investigation	2018
29269398	MiR-184 expression is regulated by AMPK in pancreatic islets.	FASEB Journal	2018
29293525	Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study.	PLoS One	2018
29849136	Publisher Correction: Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.	Nat Commun	2018
28225770	A distal intergenic region controls pancreatic endocrine differentiation by acting as a transcriptional enhancer and as a polycomb response element.	PLoS ONE	2017
28974674	Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas.	Nat Commun	2017
28838971	A Loss-of-Function Splice Acceptor Variant in <i>IGF2</i> Is Protective for Type 2 Diabetes.	Diabetes	2017
28041957	Human Pancreatic Î² Cell lncRNAs Control Cell-Specific Regulatory Networks.	Cell Metab	2017
27452146	Beta Cell Hubs Dictate Pancreatic Islet Responses toÂ Glucose.	Cell Metab	2016
26893390	The cis-regulatory switchboard of pancreatic ductal cancer.	EMBO J	2016
26911676	Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms.	Hum Mol Genet	2016
26944677	Î²linc1 encodes a long noncoding RNA that regulates islet Î²-cell formation and function.	Genes and Development	2016
26771111	Can Insulin Production Suppress Î² Cell Growth?		2016
26021489	The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice.	Diabetologia	2015
25500700	Ins1(Cre) knock-in mice for beta cell-specific gene recombination.	Diabetologia	2015
25915586	Lineage fate of ductular reactions in liver injury and carcinogenesis.	Journal of Clinical Investigation	2015
25915126	TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.	Nature Cell Biology	2015
25786211	Cell cycle-dependent differentiation dynamics balances growth and endocrine differentiation in the pancreas.	PLoS Biology	2015
25774850	Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.	Nature Medicine	2015
25355422	Selective disruption of Tcf7l2 in the pancreatic Î² cell impairs secretory function and lowers Î² cell mass.	Hum Mol Genet	2015
25758860	Weaning gives Î² cells license to regenerate.	Developmental Cell	2015
26433090	Transcriptional enhancers: functional insights and role in human disease.	Curr Opin Genet Dev	2015
26551672	Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.	Nat Genet	2015
26258299	The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia.	Nature	2015
25070369	LKB1 and AMPK differentially regulate pancreatic Î²-cell identity.	FASEB J	2014
24361012	Argonaute2 mediates compensatory expansion of the pancreatic Î² cell.		2014
24212882	Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis.	Nat Genet	2014