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Author Details

Abdu I Alayash
Center for Biologics Evaluation and Research Food and Drug Administration (FDA)
1977
164
41
PMIDPaper TitleJournal TitlePublished Year
36871490Antimicrobial 405 nm violet-blue light treatment of ex vivo human platelets leads to mitochondrial metabolic reprogramming and potential alteration of Phospho-proteome.J Photochem Photobiol B2023
37916221Changes in hemoglobin oxidation and band 3 during blood storage impact oxygen sensing and mitochondrial bioenergetic pathways in the human pulmonary arterial endothelial cell model.Front Physiol2023
36614003HIF-1α-Dependent Metabolic Reprogramming, Oxidative Stress, and Bioenergetic Dysfunction in SARS-CoV-2-Infected Hamsters.Int J Mol Sci2022
35832737Hemoglobin can Act as a (Pseudo)-Peroxidase <i>in Vivo</i>. What is the Evidence?Front Mol Biosci2022
35366607Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model.Blood Cells Mol Dis2022
35453432Hemoglobin Oxidation Reactions in Stored Blood.Antioxidants (Basel)2022
36518991Oxidation reactions of cellular and acellular hemoglobins: Implications for human health.Front Med Technol2022
32980855βCysteine 93 in human hemoglobin: a gateway to oxidative stability in health and disease.Lab Invest2021
34690793The Impact of COVID-19 Infection on Oxygen Homeostasis: A Molecular Perspective.Front Physiol2021
34510823Caffeic acid: an antioxidant with novel antisickling properties.FEBS Open Bio2021
34445747Cell-Free Hemoglobin Does Not Attenuate the Effects of SARS-CoV-2 Spike Protein S1 Subunit in Pulmonary Endothelial Cells.Int J Mol Sci2021
33386714Targeting the red cell enzyme pyruvate kinase with a small allosteric molecule AG-348 may correct underlying pathology of a glycolytic enzymopathy.Haematologica2021
32147396Corrigendum to "Structural and biochemical characterization of two heme binding sites on α1-microglobulin using site directed mutagenesis and molecular simulation" [BBAPAP 1864/1 (2016) Page 29 to 41].Biochim Biophys Acta Proteins Proteom2020
33059548Effects of α subunit substitutions on the oxidation of βCys93 and the stability of sickle cell hemoglobin.Redox Rep2020
33322551The Providence Mutation (βK82D) in Human Hemoglobin Substantially Reduces βCysteine 93 Oxidation and Oxidative Stress in Endothelial Cells.Int J Mol Sci2020
32848178Post-translational modification as a response to cellular stress induced by hemoglobin oxidation in sickle cell disease.Sci Rep2020
29112106Mechanisms of Toxicity and Modulation of Hemoglobin-based Oxygen Carriers.Shock2019
31302228Redox states of hemoglobin determine left ventricle pressure recovery and activity of mitochondrial complex IV in hypoxic rat hearts.Free Radic Biol Med2019
31396101Antisickling Drugs Targeting βCys93 Reduce Iron Oxidation and Oxidative Changes in Sickle Cell Hemoglobin.Front Physiol2019
30794381Interactions of an Anti-Sickling Drug with Hemoglobin in Red Blood Cells from a Patient with Sickle Cell Anemia.Bioconjug Chem2019
30630954Substitutions in the β subunits of sickle-cell hemoglobin improve oxidative stability and increase the delay time of sickle-cell fiber formation.J Biol Chem2019
30592074Voxelotor treatment of a patient with sickle cell disease and very severe anemia.Am J Hematol2019
28554826Oxidative pathways in the sickle cell and beyond.Blood Cells Mol Dis2018
30193183Site-directed mutagenesis of cysteine residues alters oxidative stability of fetal hemoglobin.Redox Biol2018
29802155Comparison of the oxidative reactivity of recombinant fetal and adult human hemoglobin: implications for the design of hemoglobin-based oxygen carriers.Biosci Rep2018
30385713Hemoglobin oxidation-dependent reactions promote interactions with band 3 and oxidative changes in sickle cell-derived microparticles.JCI Insight2018
29570272Comprehensive Biochemical and Biophysical Characterization of Hemoglobin-Based Oxygen Carrier Therapeutics: All HBOCs Are Not Created Equally.Bioconjug Chem2018
29427073Dissecting the biochemical architecture and morphological release pathways of the human platelet extracellular vesiculome.Cell Mol Life Sci2018
29243830Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016.Transfusion2018
27626360Exploring Oxidative Reactions in Hemoglobin Variants Using Mass Spectrometry: Lessons for Engineering Oxidatively Stable Oxygen Therapeutics.Antioxid Redox Signal2017
28398821Redox Chemistry of Hemoglobin-Associated Disorders.Antioxid Redox Signal2017
29070524Engineering oxidative stability in human hemoglobin based on the Hb providence (βK82D) mutation and genetic cross-linking.Biochem J2017
29311995Oxidized Mutant Human Hemoglobins S and E Induce Oxidative Stress and Bioenergetic Dysfunction in Human Pulmonary Endothelial Cells.Front Physiol2017
28770911Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects.Metallomics2017
28054978Hemoglobin-Based Blood Substitutes and the Treatment of Sickle Cell Disease: More Harm than Help?Biomolecules2017
28069451Determination of extinction coefficients of human hemoglobin in various redox states.Anal Biochem2017
26995402Oxidative instability of hemoglobin E (β26 Glu⿿Lys) is increased in the presence of free α subunits and reversed by α-hemoglobin stabilizing protein (AHSP): Relevance to HbE/β-thalassemia.Redox Biol2016
26497278Structural and biochemical characterization of two heme binding sites on α1-microglobulin using site directed mutagenesis and molecular simulation.Biochim Biophys Acta2016
27642551Differential heme release from various hemoglobin redox states and the upregulation of cellular heme oxygenase-1.FEBS Open Bio2016
27959920Evaluation of Stem Cell-Derived Red Blood Cells as a Transfusion Product Using a Novel Animal Model.PLoS One2016
27507623Sustained treatment of sickle cell mice with haptoglobin increases HO-1 and H-ferritin expression and decreases iron deposition in the kidney without improvement in kidney function.Br J Haematol2016
26974230Oxidized Ferric and Ferryl Forms of Hemoglobin Trigger Mitochondrial Dysfunction and Injury in Alveolar Type I Cells.Am J Respir Cell Mol Biol2016
26950293Memorial - Dr. Joseph C. Fratantoni.Artif Cells Nanomed Biotechnol2016
25582460Haptoglobin attenuates hemoglobin-induced heme oxygenase-1 in renal proximal tubule cells and kidneys of a mouse model of sickle cell disease.Blood Cells Mol Dis2015
26396189Sickle Cell Hemoglobin in the Ferryl State Promotes βCys-93 Oxidation and Mitochondrial Dysfunction in Epithelial Lung Cells (E10).J Biol Chem2015
25750627Dissection of the radical reactions linked to fetal hemoglobin reveals enhanced pseudoperoxidase activity.Front Physiol2015
24486321Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin.Free Radic Biol Med2014
25538624Characterization of heme binding to recombinant α1-microglobulin.Front Physiol2014
24939847Post-translational transformation of methionine to aspartate is catalyzed by heme iron and driven by peroxide: a novel subunit-specific mechanism in hemoglobin.J Biol Chem2014
24630491Blood substitutes: why haven't we been more successful?Trends Biotechnol2014
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Simone A Glynn
Clinical Sciences
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Charles Natanson
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Mark T Gladwin
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Sylvain Cardin
Naval Medical Research Unit San Antonio
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Griffin P Rodgers
Co-authored papers 1
Jason P Acker
University of Alberta
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Thomas J Raife
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Release 1.2