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Author Details

James J Doherty
Research and Non-clinical Development, Inc.
1997
55
28
PMIDPaper TitleJournal TitlePublished Year
37698384Pharmacological characterization of SAGE-718, a novel positive allosteric modulator of N-methyl-d-aspartate receptors.Br J Pharmacol2024
36645496Novel neuroactive steroids as positive allosteric modulators of NMDA receptors: mechanism, site of action, and rescue pharmacology on GRIN variants associated with neurological conditions.Cell Mol Life Sci2023
37491938Zuranolone for the Treatment of Postpartum Depression.Am J Psychiatry2023
37132201Zuranolone for the Treatment of Adults With Major Depressive Disorder: A Randomized, Placebo-Controlled Phase 3 Trial.Am J Psychiatry2023
34352138A phase 1 double-blind, placebo-controlled study of zuranolone (SAGE-217) in a phase advance model of insomnia in healthy adults.Hum Psychopharmacol2022
35378149Patient-reported health-related quality of life from a randomized, placebo-controlled phase 2 trial of zuranolone in adults with major depressive disorder.J Affect Disord2022
35431797Preventing Phosphorylation of the GABA <sub><i>A</i></sub> R β3 Subunit Compromises the Behavioral Effects of Neuroactive Steroids.Front Mol Neurosci2022
35785990SAGE-718: A First-in-Class <i>N</i>-Methyl-d-Aspartate Receptor Positive Allosteric Modulator for the Potential Treatment of Cognitive Impairment.J Med Chem2022
33441369Oxysterols Modulate the Acute Effects of Ethanol on Hippocampal <i>N</i>-Methyl-d-Aspartate Receptors, Long-Term Potentiation, and Learning.J Pharmacol Exp Ther2021
34190962Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial.JAMA Psychiatry2021
33387701Zuranolone as an oral adjunct to treatment of Parkinsonian tremor: A phase 2, open-label study.J Neurol Sci2021
31338688SAGE-217, A Novel GABA<sub>A</sub> Receptor Positive Allosteric Modulator: Clinical Pharmacology and Tolerability in Randomized Phase I Dose-Finding Studies.Clin Pharmacokinet2020
32976892Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABA<sub>A</sub> receptor positive allosteric modulator.Neuropharmacology2020
32830245Allosteric modulation of NMDA receptors prevents the antibody effects of patients with anti-NMDAR encephalitis.Brain2020
3255274125-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner.J Neuroinflammation2020
30804752Neuroactive Steroids Reverse Tonic Inhibitory Deficits in Fragile X Syndrome Mouse Model.Front Mol Neurosci2019
31239352Metabotropic, but not allosteric, effects of neurosteroids on GABAergic inhibition depend on the phosphorylation of GABA<sub>A</sub> receptors.J Biol Chem2019
31483961Trial of SAGE-217 in Patients with Major Depressive Disorder.N Engl J Med2019
31255299Brexanolone injection for post-partum depression treatment - Authors' reply.Lancet2019
31390523Neuroactive Steroid <i>N</i>-Methyl-d-aspartate Receptor Positive Allosteric Modulators: Synthesis, SAR, and Pharmacological Activity.J Med Chem2019
29772269A new method for determining levels of sedation in dogs: A pilot study with propofol and a novel neuroactive steroid anesthetic.J Neurosci Methods2018
29476014Positive Allosteric Modulation as a Potential Therapeutic Strategy in Anti-NMDA Receptor Encephalitis.J Neurosci2018
27743930Endogenous and synthetic neuroactive steroids evoke sustained increases in the efficacy of GABAergic inhibition via a protein kinase C-dependent mechanism.Neuropharmacology2017
28109985The synthetic neuroactive steroid SGE-516 reduces status epilepticus and neuronal cell death in a rat model of soman intoxication.Epilepsy Behav2017
28370307Open-label, proof-of-concept study of brexanolone in the treatment of severe postpartum depression.Hum Psychopharmacol2017
29127345The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model.Sci Rep2017
28753313Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid)<sub>A</sub> Receptor.J Med Chem2017
28779545Brexanolone as adjunctive therapy in super-refractory status epilepticus.Ann Neurol2017
28619476Brexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial.Lancet2017
28521115Anticonvulsant profile of the neuroactive steroid, SGE-516, in animal models.Epilepsy Res2017
26922656AZD8529, a positive allosteric modulator at the mGluR2 receptor, does not improve symptoms in schizophrenia: A proof of principle study.Schizophr Res2016
26308557Rescue of deficient amygdala tonic γ-aminobutyric acidergic currents in the Fmr-/y mouse model of fragile X syndrome by a novel γ-aminobutyric acid type A receptor-positive allosteric modulator.J Neurosci Res2016
26873083Attenuation of nicotine-taking and nicotine-seeking behavior by the mGlu2 receptor positive allosteric modulators AZD8418 and AZD8529 in rats.Psychopharmacology (Berl)2016
25377730Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel.Br J Pharmacol2015
25799373Neuroactive Steroids. 1. Positive Allosteric Modulators of the (γ-Aminobutyric Acid)A Receptor: Structure-Activity Relationships of Heterocyclic Substitution at C-21.J Med Chem2015
25253471EEG-β/γ spectral power elevation in rat: a translatable biomarker elicited by GABA(Aα2/3)-positive allosteric modulators at nonsedating anxiolytic doses.J Neurophysiol2015
24878244Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.Neuropharmacology2014
23410232AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans.J Neurochem2013
24174662The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors.J Neurosci2013
20506301Absence of direct effects on the dopamine D2 receptor by mGluR2/3-selective receptor agonists LY 354,740 and LY 379,268.Synapse2011
21045198Elucidation of a novel bioactivation pathway of a 3,4-unsubstituted isoxazole in human liver microsomes: formation of a glutathione adduct of a cyanoacrolein derivative after isoxazole ring opening.Drug Metab Dispos2011
21147987Stimulus-specific adaptation in auditory cortex is an NMDA-independent process distinct from the sensory novelty encoded by the mismatch negativity.J Neurosci2010
19615981Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.Biochem Pharmacol2009
19906975A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning.J Neurosci2009
15846002Fimbria-fornix lesions compromise the induction of long-term potentiation at the Schaffer collateral-CA1 synapse in the rat in vivo.J Neurophysiol2005
15513941Metabotropic glutamate receptors modulate feedback inhibition in a developmentally regulated manner in rat dentate gyrus.J Physiol2004
12550741Functional interactions between cannabinoid and metabotropic glutamate receptors in the central nervous system.Curr Opin Pharmacol2003
12351716Altered histone acetylation at glutamate receptor 2 and brain-derived neurotrophic factor genes is an early event triggered by status epilepticus.J Neurosci2002
12769618The roles of metabotropic glutamate receptors in seizures and epilepsy.Curr Drug Targets CNS Neurol Disord2002
11245688Reduced excitatory drive onto interneurons in the dentate gyrus after status epilepticus.J Neurosci2001
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Harvard Medical School and McLean Hospital
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Collaborators

University of North Carolina School of Medicine
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Research and Nonclinical Development, Inc.
Co-authored papers 9
AstraZeneca Pharmaceuticals
Co-authored papers 5
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Feinberg School of Medicine, Northwestern University
Co-authored papers 1
Emory University School of Medicine
Co-authored papers 1
Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine
Co-authored papers 1
Columbia University
Co-authored papers 1
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Co-authored papers 1
Seattle Children's Hospital, University of Washington
Co-authored papers 1
Beth Israel Deaconess Medical Center, Division of Neurocritical Care and Emergency Neurology, Division of Clinical Neurophysiology, Massachusetts General Hospital, Boston, MA, Harvard Medical School, Massachusetts General Hospital, Massachusetts General Hospital Fellowship in Epilepsy and Clinical Neurophysiology, Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School Fellowship Training Program in Neurocritical Care, Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School Partners Neurology Residency Training Program, Yale College
Co-authored papers 1
College of Nursing, University of South Florida
Co-authored papers 1
Duke University School of Medicine, USA Veterans Affairs Medical Center
Co-authored papers 1
Vanderbilt University School of Medicine
Co-authored papers 1
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Brigham and Women's Hospital
Co-authored papers 1
Helen and Robert Appel Alzheimer's Disease Research Institute, Cornell University
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