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Author Details

Gregory J Cost
Metagenomi Inc., Pre-clinical
1995
41
28
PMIDPaper TitleJournal TitlePublished Year
36848094Resolution of hepatic fibrosis after ZFN-mediated gene editing in the PiZ mouse model of human α1-antitrypsin deficiency.Hepatol Commun2023
37219969Novel CRISPR-Associated Gene-Editing Systems Discovered in Metagenomic Samples Enable Efficient and Specific Genome Engineering.CRISPR J2023
37272861Novel and Engineered Type II CRISPR Systems from Uncultivated Microbes with Broad Genome Editing Capability.CRISPR J2023
36522342Compact Cas9d and HEARO enzymes for genome editing discovered from uncultivated microbes.Nat Commun2022
29555974Successful knock-in of Hypertrophic Cardiomyopathy-mutation R723G into the MYH7 gene mimics HCM pathology in pigs.Sci Rep2018
30528432Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through Haplotype Editing.Cell2018
26840227Delivery of Genome Editing Reagents to Hematopoietic Stem/Progenitor Cells.Curr Protoc Stem Cell Biol2016
25733580Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells.Blood2015
24936470Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells.Stem Cell Reports2014
24989021Efficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases.Genome Res2014
25188731Genome editing-enabled HTS assays expand drug target pathways for Charcot-Marie-tooth disease.ACS Chem Biol2014
25128433Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation.Genes Dev2014
23042119In vivo cleavage of transgene donors promotes nuclease-mediated targeted integration.Biotechnol Bioeng2013
23863942Translating dosage compensation to trisomy 21.Nature2013
23161061Gene knockout and knockin by zinc-finger nucleases: current status and perspectives.Cell Mol Life Sci2013
21179091A TALE nuclease architecture for efficient genome editing.Nat Biotechnol2011
21822240Knockout rats generated by embryo microinjection of TALENs.Nat Biotechnol2011
21738127Genetic engineering of human pluripotent cells using TALE nucleases.Nat Biotechnol2011
21730124Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases.Proc Natl Acad Sci U S A2011
21347446Dissection of splicing regulation at an endogenous locus by zinc-finger nuclease-mediated gene editing.PLoS One2011
19777580BAK and BAX deletion using zinc-finger nucleases yields apoptosis-resistant CHO cells.Biotechnol Bioeng2010
21038471Characterization of immunoglobulin heavy chain knockout rats.Eur J Immunol2010
20530528Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology.Nucleic Acids Res2010
20564614Highly efficient deletion of FUT8 in CHO cell lines using zinc-finger nucleases yields cells that produce completely nonfucosylated antibodies.Biotechnol Bioeng2010
20013236Generation of gene-specific mutated rats using zinc-finger nucleases.Methods Mol Biol2010
20047187Generation of a triple-gene knockout mammalian cell line using engineered zinc-finger nucleases.Biotechnol Bioeng2010
19628861Knockout rats via embryo microinjection of zinc-finger nucleases.Science2009
19666515Retrotransposon overdose and genome integrity.Proc Natl Acad Sci U S A2009
17269489Directed assembly of DNA molecules via simultaneous ligation and digestion.Biotechniques2007
17853876Enzymatic ligation assisted by nucleases: simultaneous ligation and digestion promote the ordered assembly of DNA.Nat Protoc2007
16452135Smc5p promotes faithful chromosome transmission and DNA repair in Saccharomyces cerevisiae.Genetics2006
16936698Giant proteins that move DNA: bullies of the genomic playground.Nat Rev Mol Cell Biol2006
15681387Sequence-directed DNA translocation by purified FtsK.Science2005
12411507Human L1 element target-primed reverse transcription in vitro.EMBO J2002
12176320Human l1 retrotransposition is associated with genetic instability in vivo.Cell2002
11139628Target DNA chromatinization modulates nicking by L1 endonuclease.Nucleic Acids Res2001
9922177Targeting of human retrotransposon integration is directed by the specificity of the L1 endonuclease for regions of unusual DNA structure.Biochemistry1998
9483801Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications.Yeast1998
9041196Lack of imprinting of three human cyclin-dependent kinase inhibitor genes.Cancer Res1997
8873447A useful colony colour phenotype associated with the yeast selectable/counter-selectable marker MET15.Yeast1996
7565722A central role for a single c-Myb binding site in a thymic locus control region.Mol Cell Biol1995
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Collaborators

Fyodor D Urnov
Innovative Genomics Institute, University of California berkeley
Co-authored papers 10
Jef D Boeke
Institute for Systems Genetics, NYU School of Medicine
Co-authored papers 7
Sandra Cristea
Stanford University
Co-authored papers 2
Aron M Geurts
Co-authored papers 2
Samira Kiani
Pittsburgh Liver Research Center, University of Pittsburgh
Co-authored papers 2
Howard J Jacob
Genomics Research Center
Co-authored papers 2
Lei Zhang
University of Marburg
Co-authored papers 2
Jennifer Oki
Synthego Corporation
Co-authored papers 2
Pavel Chubukov
The Scripps Research Institute
Co-authored papers 1
Hans Clevers
Princess Maxima Center for Pediatric Oncology
Co-authored papers 1
Eric J Topol
Universidade Federal de Sao Paulo
Co-authored papers 1
Evan L Teng
University of California
Co-authored papers 1
Michael Duran
The Scripps Research Institute
Co-authored papers 1
Benjamin R Carone
Co-authored papers 1
Valentina Lo Sardo
University of Wisconsin-Madison
Co-authored papers 1
Aditya Kumar
Rice University, University of California San Diego
Co-authored papers 1
Dawn M Carone
Co-authored papers 1
William C Ferguson
The Scripps Research Institute
Co-authored papers 1
Carlos Bustamante
University of California berkeley
Co-authored papers 1
Rajarshi Guha
Vertex Pharmaceuticals
Co-authored papers 1
Ali Torkamani
Scripps Science Institute
Co-authored papers 1
Bruce J Aronow
Cincinnati Children's Hospital Medical Center
Co-authored papers 1
Lior Pachter
Co-authored papers 1
Giovanni Parmigiani
Dana Farber Cancer Institute.
Co-authored papers 1
Philip Hieter
University of British Columbia
Co-authored papers 1
Adam Wood
Saint Louis University School of Medicine
Co-authored papers 1
Andreas Neerincx
Co-authored papers 1
Kristin K Baldwin
The Scripps Research Institute
Co-authored papers 1
Erica A Moehle
Innovative Genomics Institute, University of California berkeley
Co-authored papers 1
Haoyi Wang
Chinese Academy of Sciences
Co-authored papers 1
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