Author details

Full Name

Scott A Shaffer

Affiliation

ORCID

Career Start Year

1992

Papers

113

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37498934	Immunopeptidome profiling of human coronavirus OC43-infected cells identifies CD4 T-cell epitopes specific to seasonal coronaviruses or cross-reactive with SARS-CoV-2.		2023
36286264	An additive destabilising effect of compound T60I and V122I substitutions in ATTRv amyloidosis.	Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis	2023
37549268	Targeting STING oligomerization with small-molecule inhibitors.		2023
36921042	Signal recognition particle receptor-Î² (SR-Î²) coordinates cotranslational N-glycosylation.		2023
35322228	AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice.	Nature	2022
36356199	Dual Inhibitors of Main Protease (M<sup>Pro</sup>) and Cathepsin L as Potent Antivirals against SARS-CoV2.	J Am Chem Soc	2022
35380903	Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy.	Proc Natl Acad Sci U S A	2022
35567427	Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells.	Aging Cell	2022
36482973	Immunopeptidome profiling of human coronavirus OC43-infected cells identifies CD4 T cell epitopes specific to seasonal coronaviruses or cross-reactive with SARS-CoV-2.		2022
35029059	Human neural cell type-specificÂ extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain.	J Extracell Vesicles	2022
35065666	Novel Î³-sarcoglycan interactors in murine muscle membranes.	Skelet Muscle	2022
34762412	Proximity-Dependent Labeling of Cysteines.	Journal of the American Chemical Society	2021
34051146	Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells.	Immunity	2021
33875592	A conserved folding nucleus sculpts the free energy landscape of bacterial and archaeal orthologs from a divergent TIM barrel family.	Proceedings of the National Academy of Sciences of the United States of America	2021
34522610	Identification of novel inhibitory metabolites and impact verification on growth and protein synthesis in mammalian cells.	Metabolic Engineering Communications	2021
34491035	A Streamlined Data Analysis Pipeline for the Identification of Sites of Citrullination.	Biochemistry	2021
32820063	Succination inactivates gasdermin D and blocks pyroptosis.	Science	2020
32415538	In-Vitro Sorbent-Mediated Removal of Edoxaban from Human Plasma and Albumin Solution.	Drugs in R and D	2020
32005680	Technical comment on "Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis".	Science immunology	2020
32828068	Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: A liquid chromatography-tandem mass spectrometry analysis.	Psychoneuroendocrinology	2020
31296534	Quantitative glycoproteomics reveals new classes of STT3A- and STT3B-dependent N-glycosylation sites.	Journal of Cell Biology	2019
30573663	HLA-DO Modulates the Diversity of the MHC-II Self-peptidome.	Molecular and Cellular Proteomics	2019
30327498	Resting-state functional connectivity, cortical GABA, and neuroactive steroids in peripartum and peripartum depressed women: a functional magnetic resonanceÂ imaging and spectroscopyÂ study.	Neuropsychopharmacology	2019
31020640	Naturally processed HLA-DR3-restricted HHV-6B peptides are recognized broadly with polyfunctional and cytotoxic CD4 T-cell responses.	Eur J Immunol	2019
30806671	Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS.	Human Molecular Genetics	2019
31195240	Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition.	iScience	2019
29735996	C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2.	Nat Methods	2018
28747086	Menthol enhances nicotine-induced locomotor sensitization and in vivo functional connectivity in adolescence.	Journal of Psychopharmacology	2018
30341012	Exosomes Produced from 3D Cultures of MSCs by Tangential Flow Filtration Show Higher Yield and Improved Activity.	Mol Ther	2018
30481169	Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation.	PLoS Biology	2018
30318462	A Lysine Acetyltransferase Contributes to the Metabolic Adaptation to Hypoxia in Mycobacterium tuberculosis.	Cell Chemical Biology	2018
29212905	Cyclic GMP-AMP Synthase Is the Cytosolic Sensor of Genomic DNA and Activates Type I IFN in Malaria.	Journal of Immunology	2018
29251792	Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation through heat shock protein 90.	Hepatology	2018
28165127	Novel allele-specific quantification methods reveal no effects of adult onset CAG repeats on HTT mRNA and protein levels.	Human Molecular Genetics	2017
28504669	Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis.	Nat Microbiol	2017
28377500	Innate immune signaling in is regulated by transforming growth factor Î² (TGFÎ²)-activated kinase (Tak1)-triggered ubiquitin editing.	Journal of Biological Chemistry	2017
29090078	RNA sequencing and proteomics approaches reveal novel deficits in the cortex of <i>Mecp2</i>-deficient mice, a model for Rett syndrome.	Mol Autism	2017
27863537	High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources.	J Extracell Vesicles	2016
26740625	The Dendritic Cell Major Histocompatibility Complex II (MHC II) Peptidome Derives from a Variety of Processing Pathways and Includes Peptides with a Broad Spectrum of HLA-DM Sensitivity.	J Biol Chem	2016
27264171	Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4.	Cell Reports	2016
27209438	Peripartum neuroactive steroid and Î³-aminobutyric acid profiles in women at-risk for postpartum depression.	Psychoneuroendocrinology	2016
27114527	Spatially distinct and metabolically active membrane domain in mycobacteria.	Proc Natl Acad Sci U S A	2016
26220577	Macrophage secretome from women with HIV-associated neurocognitive disorders.	Proteomics - Clinical Applications	2016
27659423	A novel transgenic mouse model of lysosomal storage disorder.	American Journal of Physiology - Gastrointestinal and Liver Physiology	2016
26446795	The Exocyst Subunit Sec6 Interacts with Assembled Exocytic SNARE Complexes.	J Biol Chem	2015
25609707	Subnuclear domain proteins in cancer cells support the functions of RUNX2 in the DNA damage response.	J Cell Sci	2015
25964428	Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice reduces lysosomal storage in CNS and extends lifespan.	Human Molecular Genetics	2015
26397899	Mass Spectrometry Analysis of Wild-Type and Knock-in Q140/Q140 Huntington's Disease Mouse Brains Reveals Changes in Glycerophospholipids Including Alterations in Phosphatidic Acid and Lyso-Phosphatidic Acid.	J Huntingtons Dis	2015
26081415	Opposing calcium-dependent signalling pathways control skeletal muscle differentiation by regulating a chromatin remodelling enzyme.	Nature Communications	2015
26208400	Interacting partners of macrophage-secreted cathepsin B contribute to HIV-induced neuronal apoptosis.	AIDS	2015