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Author Details

Dennis J Slamon
David Geffen School of Medicine at university of california los angeles
1973
349
110
PMIDPaper TitleJournal TitlePublished Year
36136304Preclinical and Clinical Trial Results Using Talazoparib and Low-Dose Chemotherapy.Clin Cancer Res2023
37915024Correction: PP2A inhibition overcomes acquired resistance to HER2 targeted therapy.Mol Cancer2023
37653397Updated overall survival from the MONALEESA-3 trial in postmenopausal women with HR+/HER2- advanced breast cancer receiving first-line ribociclib plus fulvestrant.Breast Cancer Res2023
37788341Development of a Novel CLDN18.2-directed Monoclonal Antibody and Antibody-Drug Conjugate for Treatment of CLDN18.2-Positive Cancers.Mol Cancer Ther2023
37219486Integrative transcriptomics and cell systems analyses reveal protective pathways controlled by Igfbp-3 in anthracycline-induced cardiotoxicity.FASEB J2023
37275963Rationale and trial design of NATALEE: a Phase III trial of adjuvant ribociclibâ¿¿+â¿¿endocrine therapy <i>versus</i> endocrine therapy alone in patients with HR+/HER2- early breast cancer.Ther Adv Med Oncol2023
36884217Preclinical Efficacy of the Antibody-Drug Conjugate CLDN6-23-ADC for the Treatment of CLDN6-Positive Solid Tumors.Clin Cancer Res2023
36921335Efficacy and Safety of Trastuzumab as a Single Agent in First-Line Treatment of HER2-Overexpressing Metastatic Breast Cancer.J Clin Oncol2023
36881998Multinational Study of the Efficacy and Safety of Humanized Anti-HER2 Monoclonal Antibody in Women Who Have HER2-Overexpressing Metastatic Breast Cancer That Has Progressed After Chemotherapy for Metastatic Disease.J Clin Oncol2023
36709663Results of TRIO-15, a multicenter, open-label, phase II study of the efficacy and safety of ganitumab in patients with recurrent platinum-sensitive ovarian cancer.Gynecol Oncol2023
36631725Tumor biomarkers and efficacy in patients treated with trastuzumab emtansineâ¿¿+â¿¿pertuzumab versus standard of care in HER2-positive early breast cancer: an open-label, phase III study (KRISTINE).Breast Cancer Res2023
36564285Corrigendum to "Tucatinib versus placebo added to trastuzumab and capecitabine for patients with pretreated HER2D metastatic breast cancer with and without brain metastases (HER2CLIMB): final overall survival analysis": [Annals of Oncology 33 (2022) 321-329].Ann Oncol2023
36454580Tucatinib vs Placebo, Both in Combination With Trastuzumab and Capecitabine, for Previously Treated ERBB2 (HER2)-Positive Metastatic Breast Cancer in Patients With Brain Metastases: Updated Exploratory Analysis of the HER2CLIMB Randomized Clinical Trial.JAMA Oncol2023
35110416Genetic Polymorphisms and Correlation with Treatment-Induced Cardiotoxicity and Prognosis in Patients with Breast Cancer.Clin Cancer Res2022
35417017Tucatinib has Selective Activity in HER2-Positive Cancers and Significant Combined Activity with Approved and Novel Breast Cancer-Targeted Therapies.Mol Cancer Ther2022
35552673Overall Survival with Palbociclib and Fulvestrant in Women with HR+/HER2- ABC: Updated Exploratory Analyses of PALOMA-3, a Double-blind, Phase III Randomized Study.Clin Cancer Res2022
36291835Event-Free Survival in Patients with Early HER2-Positive Breast Cancer with a Pathological Complete Response after HER2-Targeted Therapy: A Pooled Analysis.Cancers (Basel)2022
35917168Targeting CDK4 and 6 in Cancer Therapy: Emerging Preclinical Insights Related to Abemaciclib.Oncologist2022
34954044Tucatinib versus placebo added to trastuzumab and capecitabine for patients with pretreated HER2+ metastatic breast cancer with and without brain metastases (HER2CLIMB): final overall survival analysis.Ann Oncol2022
34980598Sapanisertib plus Fulvestrant in Postmenopausal Women with Estrogen Receptor-Positive/HER2-Negative Advanced Breast Cancer after Progression on Aromatase Inhibitor.Clin Cancer Res2022
33369581Frontiers in HER2-positive breast cancer in 2020.Curr Opin Obstet Gynecol2021
34966897Spatial proteomic characterization of HER2-positive breast tumors through neoadjuvant therapy predicts response.Nat Cancer2021
34470810Correction: Activation of the IFN Signaling Pathway is Associated with Resistance to CDK4/6 Inhibitors and Immune Checkpoint Activation in ER-Positive Breast Cancer.Clin Cancer Res2021
34381210Cycling cancer persister cells arise from lineages with distinct programs.Nature2021
34642026Results of TRIO-14, a phase II, multicenter, randomized, placebo-controlled trial of carboplatin-paclitaxel versus carboplatin-paclitaxel-ganitumab in newly diagnosed epithelial ovarian cancer.Gynecol Oncol2021
34625570A careful reassessment of anthracycline use in curable breast cancer.NPJ Breast Cancer2021
34102253Ribociclib plus fulvestrant for postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer in the phase III randomized MONALEESA-3 trial: updated overall survival.Ann Oncol2021
33951110Clinical evaluation of BCL-2/XL levels pre- and post- HER2-targeted therapy.PLoS One2021
33229045Analysis in epithelial ovarian cancer identifies KANSL1 as a biomarker and target gene for immune response and HDAC inhibition.Gynecol Oncol2021
31448513Efficacy and safety of palbociclib plus endocrine therapy in North American women with hormone receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer.Breast J2020
31825569Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer.N Engl J Med2020
33157050Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines.Cancer Cell2020
33203854Pathologic and molecular responses to neoadjuvant trastuzumab and/or lapatinib from a phase II randomized trial in HER2-positive breast cancer (TRIO-US B07).Nat Commun2020
32683565Overall survival results from the randomized phase 2 study of palbociclib in combination with letrozole versus letrozole alone for first-line treatment of ER+/HER2- advanced breast cancer (PALOMA-1, TRIO-18).Breast Cancer Res Treat2020
32795346Targeting activated PI3K/mTOR signaling overcomes acquired resistance to CDK4/6-based therapies in preclinical models of hormone receptor-positive breast cancer.Breast Cancer Res2020
32783178Treatment effect of palbociclib plus endocrine therapy by prognostic and intrinsic subtype and biomarker analysis in patients with bone-only disease: a joint analysis of PALOMA-2 and PALOMA-3 clinical trials.Breast Cancer Res Treat2020
32554541Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE).Clin Cancer Res2020
32473302Prognostic gene expression signature for high-grade serous ovarian cancer.Ann Oncol2020
31615937Potent Cell-Cycle Inhibition and Upregulation of Immune Response with Abemaciclib and Anastrozole in neoMONARCH, Phase II Neoadjuvant Study in HR<sup>+</sup>/HER2<sup>-</sup> Breast Cancer.Clin Cancer Res2020
31527167Biomarker Analyses of Response to Cyclin-Dependent Kinase 4/6 Inhibition and Endocrine Therapy in Women with Treatment-Naïve Metastatic Breast Cancer.Clin Cancer Res2020
30573544Concise total syntheses of (-)-jorunnamycin A and (-)-jorumycin enabled by asymmetric catalysis.Science2019
30032196Long-term Pooled Safety Analysis of Palbociclib in Combination With Endocrine Therapy for HR+/HER2- Advanced Breast Cancer.J Natl Cancer Inst2019
31446981Luminespib plus pemetrexed in patients with non-squamous non-small cell lung cancer.Lung Cancer2019
31303643Safety and tolerability of CFI-400945, a first-in-class, selective PLK4 inhibitor in advanced solid tumours: a phase 1 dose-escalation trial.Br J Cancer2019
31157583Neoadjuvant Trastuzumab Emtansine and Pertuzumab in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: Three-Year Outcomes From the Phase III KRISTINE Study.J Clin Oncol2019
30868391Prognostic effect of Ki-67 in common clinical subgroups of patients with HER2-negative, hormone receptor-positive early breast cancer.Breast Cancer Res Treat2019
31097597Role for polo-like kinase 4 in mediation of cytokinesis.Proc Natl Acad Sci U S A2019
30709633Disease-free survival as a surrogate for overall survival in patients with HER2-positive, early breast cancer in trials of adjuvant trastuzumab for up to 1 year: a systematic review and meta-analysis.Lancet Oncol2019
30962322Neutralization of BCL-2/XL Enhances the Cytotoxicity of T-DM1 In Vivo.Mol Cancer Ther2019
30632023Palbociclib plus letrozole as first-line therapy in estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer with extended follow-up.Breast Cancer Res Treat2019
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Collaborators

Co-authored papers 44
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David Geffen School of Medicine, University of California los angeles
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Otto-Friedrich-University Bamberg
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QIMR Berghofer Medical Research Institute
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The M. Sklodowska-Curie Cancer Center and Institute of Oncology
Co-authored papers 5
German Cancer Research Center (DKFZ)
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University of California San Francisco
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Mayo Clinic
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University Claude Bernard Lyon I
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David Geffen School of Medicine at university of california los angeles
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Mayo Clinic
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