Author details

Full Name

Richard L Klemke

Affiliation

ORCID

Career Start Year

1993

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
34931077	Genetically engineered and enucleated human mesenchymal stromal cells for the targeted delivery of therapeutics to diseased tissue.	Nature Biomedical Engineering	2022
34422650	The Heparan Sulfate Binding Peptide in Tumor Progression of Triple-Negative Breast Cancer.	Frontiers in Oncology	2021
34428425	Bladder Cancer Invasion Is Mediated by Mammalian Target of Rapamycin Complex 2-Driven Regulation of Nitric Oxide and Invadopodia Formation.	American Journal of Pathology	2021
29321164	KRAS Oncoprotein Expression Is Regulated by a Self-Governing eIF5A-PEAK1 Feed-Forward Regulatory Loop.	Cancer Research	2018
29872538	Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription.	Cell Discov	2018
30003430	Transplantation of Human-Induced Pluripotent Stem Cell-Derived Neural Precursors into Early-Stage Zebrafish Embryos.	Journal of Molecular Neuroscience	2018
29355494	ADAMTS-1 disrupts HGF/c-MET signaling and HGF-stimulated cellular processes in fibrosarcoma.	Experimental Cell Research	2018
29445239	The Urokinase Receptor Induces a Mesenchymal Gene Expression Signature in Glioblastoma Cells and Promotes Tumor Cell Survival in Neurospheres.	Sci Rep	2018
29615667	Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply.	Nat Commun	2018
28381547	eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth.	Cancer Res	2017
24997994	Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation.	Mol Cell Proteomics	2015
26483550	Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels.	Journal of Biological Chemistry	2015
26267863	PEAK1 Acts as a Molecular Switch to Regulate Context-Dependent TGFÎ² Responses in Breast Cancer.	PLoS ONE	2015
24749068	CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo.	Stem Cell Reports	2014
25261239	A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer.	Cancer Res	2014
24161902	Procedures for the biochemical enrichment and proteomic analysis of the cytoskeletome.	Analytical Biochemistry	2014
23105102	Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover.	J Biol Chem	2013
23868590	Proteomic and biochemical methods to study the cytoskeletome.	Methods in Molecular Biology	2013
23321642	Role of connexins in metastatic breast cancer and melanoma brain colonization.	J Cell Sci	2013
21909922	Proteomics method for identification of pseudopodium phosphotyrosine proteins.	Methods in Molecular Biology	2012
22809641	Cancer cell migration within 3D layer-by-layer microfabricated photocrosslinked PEG scaffolds with tunable stiffness.	Biomaterials	2012
22589274	KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer.	Cancer Res	2012
22980730	Trespassing cancer cells: 'fingerprinting' invasive protrusions reveals metastatic culprits.	Current Opinion in Cell Biology	2012
21500348	Reversed-phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells.	Proteomics	2011
21454597	Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction.	J Biol Chem	2011
20154271	Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF.	Proceedings of the National Academy of Sciences of the United States of America	2010
21301050	PEAK1, a novel kinase target in the fight against cancer.	Oncotarget	2010
20940399	Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells.	Cancer Res	2010
20826718	A PKA-Csk-pp60Src signaling pathway regulates the switch between endothelial cell invasion and cell-cell adhesion during vascular sprouting.	Blood	2010
20534451	Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected].	Proc Natl Acad Sci U S A	2010
20530574	Visualizing extravasation dynamics of metastatic tumor cells.	J Cell Sci	2010
20156452	Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1.	J Mol Biol	2010
19265037	Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish.	Circulation Research	2009
19696929	Chemoattractant signaling between tumor cells and macrophages regulates cancer cell migration, metastasis and neovascularization.	PLoS One	2009
18268346	The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8.	Proc Natl Acad Sci U S A	2008
17934212	PhosphoBlast, a computational tool for comparing phosphoprotein signatures among large datasets.	Molecular and Cellular Proteomics	2008
18245386	Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network.	Proc Natl Acad Sci U S A	2008
18372910	Catch of the day: zebrafish as a human cancer model.	Oncogene	2008
18785766	Quantitative phosphoproteome analysis of lysophosphatidic acid induced chemotaxis applying dual-step (18)O labeling coupled with immobilized metal-ion affinity chromatography.	J Proteome Res	2008
17494752	Profiling signaling polarity in chemotactic cells.	Proc Natl Acad Sci U S A	2007
17954920	High-resolution imaging of the dynamic tumor cell vascular interface in transparent zebrafish.	Proc Natl Acad Sci U S A	2007
17712138	Methods for pseudopodia purification and proteomic analysis.	Sci STKE	2007
17416987	Biochemical purification of pseudopodia from migratory cells.	Methods in Molecular Biology	2007
16267043	Deregulation of proteasome function induces Abl-mediated cell death by uncoupling p130CAS and c-CrkII.	Journal of Biological Chemistry	2006
16547516	Spatiotemporal dynamics of RhoA activity in migrating cells.	Nature	2006
16602698	Computational methods for comparison of large genomic and proteomic datasets reveal protein markers of metastatic cancer.	Journal of Proteome Research	2006
15525681	R-Ras controls membrane protrusion and cell migration through the spatial regulation of Rac and Rho.	Molecular Biology of the Cell	2005
15138294	Regulation of cell migration and survival by focal adhesion targeting of Lasp-1.	J Cell Biol	2004
15501442	Guiding cell migration through directed extension and stabilization of pseudopodia.	Experimental Cell Research	2004
15246680	Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold.		2004