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Author Details

Peter H Sugden
1970
185
62
PMIDPaper TitleJournal TitlePublished Year
35147166Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo.Biochemical Journal2022
35766350The insulin receptor family in the heart: new light on old insights.Bioscience Reports2022
36331065Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice.Clinical Science2022
34032269MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins.Biochem J2021
34296750The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension.Clinical Science2021
34002209The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α1-adrenergic receptors.Biochemical Journal2021
32903101Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension.Hypertension2020
30771309The cardiomyocyte "redox rheostat": Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death.Journal of Molecular and Cellular Cardiology2019
26260799Cardiac protein kinases: the cardiomyocyte kinome and differential kinase expression in human failing hearts.Cardiovascular Research2015
23215897p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists.Biochemical Journal2013
23889253SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions.Biochem J2013
23219998The early transcriptomic response to interleukin 1β and interleukin 33 in rat neonatal cardiomyocytes.Cytokine2013
22229648A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3).Biochem J2012
30764011Actions and interactions of AMPK with insulin, the peroxisomal-proliferator activated receptors and sirtuins.2012
22390138Feedback regulation by Atf3 in the endothelin-1-responsive transcriptome of cardiomyocytes: Egr1 is a principal Atf3 target.Biochemical Journal2012
21730291MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis.Molecular and Cellular Biology2011
21044683Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active.Cellular Signalling2011
21169385Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology.Eur J Heart Fail2011
21262993Conditional transgenic expression of fibroblast growth factor 9 in the adult mouse heart reduces heart failure mortality after myocardial infarction.Circulation2011
21708908Towards a re-definition of 'cardiac hypertrophy' through a rational characterization of left ventricular phenotypes: a position paper of the Working Group 'Myocardial Function' of the ESC.European Journal of Heart Failure2011
19861169Modulation of interleukin signalling and gene expression in cardiac myocytes by endothelin-1.International Journal of Biochemistry and Cell Biology2010
20509958Regulation of the cardiomyocyte transcriptome vs translatome by endothelin-1 and insulin: translational regulation of 5' terminal oligopyrimidine tract (TOP) mRNAs by insulin.BMC Genomics2010
20368814ERK1/2 signaling dominates over RhoA signaling in regulating early changes in RNA expression induced by endothelin-1 in neonatal rat cardiomyocytes.PLoS ONE2010
19861307Dying by the way you live: AIF vs. caspases in apoptosis of hypertrophied cardiomyocytes.Cardiovascular Research2010
19192484Endothelin-1 regulation of immediate early gene expression in cardiac myocytes: negative feedback regulation of interleukin 6 by Atf3 and Klf2.2009
19406269Effects of left ventricular volume overload on mitochondrial and death-receptor-mediated apoptotic pathways in the transition to heart failure.American Journal of Cardiology2009
19638633Regulation of expression of the rat orthologue of mouse double minute 2 (MDM2) by H(2)O(2)-induced oxidative stress in neonatal rat cardiac myocytes.Journal of Biological Chemistry2009
19071133Are transgenic mice the 'alkahest' to understanding myocardial hypertrophy and failure?Journal of Molecular and Cellular Cardiology2009
18406357Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines.2008
17993264Glycogen synthase kinases 3alpha and 3beta in cardiac myocytes: regulation and consequences of their inhibition.Cellular Signalling2008
18204489Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis.British Journal of Pharmacology2008
18430438ErbB receptors, their ligands, and the consequences of their activation and inhibition in the myocardium.Journal of Molecular and Cellular Cardiology2008
18555663Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors.Cellular Signalling2008
18275597Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes.2008
17343902Chemotherapeutic agents and gene expression in cardiac myocytes.2007
17450511Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses.Journal of Cellular Physiology2007
17148688Cardiac myocyte gene expression profiling during H2O2-induced apoptosis.Physiological Genomics2007
16324708Effects of oxidative stress on the cardiac myocyte proteome: modifications to peroxiredoxins and small heat shock proteins.Journal of Molecular and Cellular Cardiology2006
15936927Peptide growth factors signal differentially through protein kinase C to extracellular signal-regulated kinases in neonatal cardiomyocytes.Cellular Signalling2006
16756989Using U0126 to dissect the role of the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade in the regulation of gene expression by endothelin-1 in cardiac myocytes.Journal of Molecular and Cellular Cardiology2006
16361709Regulation of protein kinase C delta by phorbol ester, endothelin-1, and platelet-derived growth factor in cardiac myocytes.Journal of Biological Chemistry2006
16908028Ras: the stress and the strain.Journal of Molecular and Cellular Cardiology2006
16946139Inflame my heart (by p38-MAPK).Circulation Research2006
17034354Oxidative stress and growth-regulating intracellular signaling pathways in cardiac myocytes.Antioxidants and Redox Signaling2006
16248777Endothelin signalling in the cardiac myocyte and its pathophysiological relevance.Current Vascular Pharmacology2005
15558028Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants.Oncogene2005
16084574Regulation of gene and protein expression in cardiac myocyte hypertrophy and apoptosis.2005
14741741Endothelin-1 promotes phosphorylation of CREB transcription factor in primary cultures of neonatal rat cardiac myocytes: implications for the regulation of c-jun expression.2004
15276029Phenylephrine and endothelin-1 upregulate connective tissue growth factor in neonatal rat cardiac myocytes.Journal of Molecular and Cellular Cardiology2004
15581493Integration of protein kinase signaling pathways in cardiac myocytes: signaling to and from the extracellular signal-regulated kinases.2004
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