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Author Details

Janko Nikolich-Zugich
University of Arizona Center on Aging, University of Arizona
2000
148
51
PMIDPaper TitleJournal TitlePublished Year
37195387Targeted metabolomics reveals plasma biomarkers and metabolic alterations of the aging process in healthy young and older adults.Geroscience2023
34633448Age-Related Differences in T-Cell Subsets in a Nationally Representative Sample of People Older Than Age 55: Findings From the Health and Retirement Study.J Gerontol A Biol Sci Med Sci2022
35610270Competent immune responses to SARS-CoV-2 variants in older adults following two doses of mRNA vaccination.Nat Commun2022
35439062Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging.Proc Natl Acad Sci U S A2022
35605008CD4 T-cell depletion prevents Lassa fever associated hearing loss in the mouse model.PLoS Pathog2022
35657768Lifelong cytomegalovirus and early-LIFE irradiation synergistically potentiate age-related defects in response to vaccination and infection.Aging Cell2022
35562119Cutting Edge: T Cell Responses to B.1.1.529 (Omicron) SARS-CoV-2 Variant Induced by COVID-19 Infection and/or mRNA Vaccination Are Largely Preserved.J Immunol2022
35450423Sensitive, smartphone-based SARS-CoV-2 detection from clinical saline gargle samples.PNAS Nexus2022
35858901Evaluation of T-cell aging-related immune phenotypes in the context of biological aging and multimorbidity in the Health and Retirement Study.Immun Ageing2022
35849213Aging alters antiviral signaling pathways resulting in functional impairment in innate immunity in response to pattern recognition receptor agonists.Geroscience2022
35975357Inflammatory and immune markers in HIV-infected older adults on long-term antiretroviral therapy: Persistent elevation of sCD14 and of proinflammatory effector memory T cells.Aging Cell2022
35289071Quantitative restoration of immune defense in old animals determined by naive antigen-specific CD8 T-cell numbers.Aging Cell2022
35001661Splenocyte transfer from hypertensive donors eliminates premenopausal female protection from ANG II-induced hypertension.Am J Physiol Renal Physiol2022
34973565Direct capture and smartphone quantification of airborne SARS-CoV-2 on a paper microfluidic chip.Biosens Bioelectron2022
34902435The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression.J Allergy Clin Immunol2022
34928334Neutralizing Antibody Response to Pseudotype Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Differs Between mRNA-1273 and BNT162b2 Coronavirus Disease 2019 (COVID-19) Vaccines and by History of SARS-CoV-2 Infection.Clin Infect Dis2022
35334331Smartphone-based sensitive detection of SARS-CoV-2 from saline gargle samples via flow profile analysis on a paper microfluidic chip.Biosens Bioelectron2022
32909616Cytomegalovirus and Your Health: Not a Matter of the Heart, Nor of Life and Death.J Infect Dis2021
36908301Research and resource needs for understanding host immune responses to SARS-CoV-2 and COVID-19 vaccines during aging.Nat Aging2021
33629207IL-6 can singlehandedly drive many features of frailty in mice.Geroscience2021
34525378Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells.Stem Cell Reports2021
34489451Infection-induced type I interferons critically modulate the homeostasis and function of CD8<sup>+</sup> naïve T cells.Nat Commun2021
34594036Immune responses to two and three doses of the BNT162b2 mRNA vaccine in adults with solid tumors.Nat Med2021
34057904COVID-19 Infection, Reinfection, and Vaccine Effectiveness in a Prospective Cohort of Arizona Frontline/Essential Workers: The AZ HEROES Research Protocol.JMIR Res Protoc2021
34140221Immune response to COVID-19 in older adults.J Heart Lung Transplant2021
33160186Immunity to acute virus infections with advanced age.Curr Opin Virol2021
33358868Strategies to DAMPen COVID-19-mediated lung and systemic inflammation and vascular injury.Transl Res2021
32162210Advances in cytomegalovirus (CMV) biology and its relationship to health, diseases, and aging.Geroscience2020
33129373Orthogonal SARS-CoV-2 Serological Assays Enable Surveillance of Low-Prevalence Communities and Reveal Durable Humoral Immunity.Immunity2020
32887754Antibody Responses to SARS-CoV-2: Let's Stick to Known Knowns.J Immunol2020
32849497Corrigendum: Defective Transcriptional Programming of Effector CD8 T Cells in Aged Mice Is Cell-Extrinsic and Can Be Corrected by Administration of IL-12 and IL-18.Front Immunol2020
32817969Detection, prevalence, and duration of humoral responses to SARS-CoV-2 under conditions of limited population exposure.medRxiv2020
33010224Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses.Immunity2020
32363428Correction to: SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes.Geroscience2020
32274617SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes.Geroscience2020
30430748Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates.Aging Cell2019
31747595Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency.Cell Rep2019
31220189Life-long control of cytomegalovirus (CMV) by T resident memory cells in the adipose tissue results in inflammation and hyperglycemia.PLoS Pathog2019
31620129Defective Transcriptional Programming of Effector CD8 T Cells in Aged Mice Is Cell-Extrinsic and Can Be Corrected by Administration of IL-12 and IL-18.Front Immunol2019
31099612Menopause and FOXP3<sup>+</sup> Treg cell depletion eliminate female protection against T cell-mediated angiotensin II hypertension.Am J Physiol Heart Circ Physiol2019
31069636Do cytomegalovirus-specific memory T cells interfere with new immune responses in lymphoid tissues?Geroscience2019
30833015Frailty as a prognostic factor for the critically ill older adult trauma patients.Am J Surg2019
30768559The acute inflammatory response after trauma is heightened by frailty: A prospective evaluation of inflammatory and endocrine system alterations in frailty.J Trauma Acute Care Surg2019
31004198Impact of CMV upon immune aging: facts and fiction.Med Microbiol Immunol2019
28582491Role of Cell-Intrinsic and Environmental Age-Related Changes in Altered Maintenance of Murine T Cells in Lymphoid Organs.J Gerontol A Biol Sci Med Sci2018
29864157A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice.PLoS One2018
29804201Calorie restriction induces reversible lymphopenia and lymphoid organ atrophy due to cell redistribution.Geroscience2018
29967140Lifelong CMV infection improves immune defense in old mice by broadening the mobilized TCR repertoire against third-party infection.Proc Natl Acad Sci U S A2018
30177814Author Correction: The twilight of immunity: emerging concepts in aging of the immune system.Nat Immunol2018
30343875Prospective evaluation of frailty and functional independence in older adult trauma patients.Am J Surg2018
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Collaborators

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Co-authored papers 9
Oregon Health & Science University
Co-authored papers 8
Vaccine & Gene Therapy Institute, Oregon Health & Science University
Co-authored papers 8
Vaccine and Gene Therapy Institute, Oregon Health & Science University
Co-authored papers 5
Washington University School of Medicine
Co-authored papers 4
University of Arizona
Co-authored papers 4
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Co-authored papers 3
University of Arizona
Co-authored papers 3
St Jude Children's Research Hospital.
Co-authored papers 3
Case Western Reserve University
Co-authored papers 3
Vaccine and Gene Therapy Institute, Oregon Health and Science University
Co-authored papers 3
Marshfield Clinic Research Institute, Marshfield Clinic Health System
Co-authored papers 2
Co-authored papers 2
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Centers for Disease Control and Prevention (CDC)
Co-authored papers 2
Cerus Corporation
Co-authored papers 2
College of Public Health, The University of Arizona
Co-authored papers 2
Vaccine & Gene Therapy Institute, and Oregon National Primate Research Center
Co-authored papers 2
Co-authored papers 2
Vaccine and Gene Therapy Institute, Oregon Health and Science University
Co-authored papers 2
Vitalant Research Institute
Co-authored papers 2
Comprehensive Cancer Center
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Centro Hospitalar Conde de Sao Januario
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Co-authored papers 1
Center for Innate Immunity and Immune Disease, University of Washington
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Division of Clinical Trials and Biostatistics, Mayo Clinic
Co-authored papers 1
Lineberger Cancer Center, University of North Carolina
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