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Author Details

Andrea Sottoriva
The Institute of Cancer Research, UK Computational Biology Research Centre
2010
64
31
PMIDPaper TitleJournal TitlePublished Year
38047596Cancer Evolution: A Multifaceted Affair.Cancer Discov2024
37968225Phenotypic noise and plasticity in cancer evolution.Trends Cell Biol2024
36894710Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors.Nat Genet2023
38030613Contribution of pks<sup>+</sup> E. coli mutations to colorectal carcinogenesis.Nat Commun2023
34933802Circulating tumour DNA sequencing to determine therapeutic response and identify tumour heterogeneity in patients with paediatric solid tumours.Eur J Cancer2022
35379804Immunosuppressive niche engineering at the onset of human colorectal cancer.Nat Commun2022
35460607Germline MBD4 deficiency causes a multi-tumor predisposition syndrome.Am J Hum Genet2022
36044867Quantification of spatial subclonal interactions enhancing the invasive phenotype of pediatric glioma.Cell Rep2022
33199443EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers.Gut2021
34211178Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns.Nat Genet2021
32221288Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking.Nat Commun2020
31967692Prediction of Benefit from Checkpoint Inhibitors in Mismatch Repair Deficient Metastatic Colorectal Cancer: Role of Tumor Infiltrating Lymphocytes.Oncologist2020
32098957Measuring single cell divisions in human tissues from multi-region sequencing data.Nat Commun2020
31659302Author Correction: Resolving genetic heterogeneity in cancer.Nat Rev Genet2020
33203356The MOBSTER R package for tumour subclonal deconvolution from bulk DNA whole-genome sequencing data.BMC Bioinformatics2020
32879509Subclonal reconstruction of tumors by using machine learning and population genetics.Nat Genet2020
32929288Evolutionary dynamics of neoantigens in growing tumors.Nat Genet2020
32759276Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype.Sci Transl Med2020
32317663Exploiting evolutionary steering to induce collateral drug sensitivity in cancer.Nat Commun2020
32223898Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios.Elife2020
30452544Evolutionary dynamics of residual disease in human glioblastoma.Ann Oncol2019
31648981Analysis of tumour ecological balance reveals resource-dependent adaptive strategies of ovarian cancer.EBioMedicine2019
31356595Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data.PLoS Comput Biol2019
30918367Resolving genetic heterogeneity in cancer.Nat Rev Genet2019
31059289Measuring Clonal Evolution in Cancer with Genomics.Annu Rev Genomics Hum Genet2019
29722787Divergent adaptation in thyroid cancers.Ann Oncol2018
30166348Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial.Cancer Discov2018
29891724The Spatiotemporal Evolution of Lymph Node Spread in Early Breast Cancer.Clin Cancer Res2018
29808029Quantification of subclonal selection in cancer from bulk sequencing data.Nat Genet2018
30022114Author Correction: Quantification of subclonal selection in cancer from bulk sequencing data.Nat Genet2018
30254278Microenvironmental niche divergence shapes BRCA1-dysregulated ovarian cancer morphological plasticity.Nat Commun2018
30177804The evolutionary landscape of colorectal tumorigenesis.Nat Ecol Evol2018
29879111Variation of mutational burden in healthy human tissues suggests non-random strand segregation and allows measuring somatic mutation rates.PLoS Comput Biol2018
30250125Reply to 'Revisiting signatures of neutral tumor evolution in the light of complexity of cancer genomic data'.Nat Genet2018
30171232Detecting repeated cancer evolution from multi-region tumor sequencing data.Nat Methods2018
30374073Reply to 'Neutral tumor evolution?'.Nat Genet2018
30374070Reply to 'Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution'.Nat Genet2018
29472484Patient-derived organoids model treatment response of metastatic gastrointestinal cancers.Science2018
28069394Catch my drift? Making sense of genomic intra-tumour heterogeneity.Biochim Biophys Acta Rev Cancer2017
28327965Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer.Ann Oncol2017
28344344Detecting truly clonal alterations from multi-region profiling of tumours.Sci Rep2017
29222441Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.Nat Commun2017
28912577Classifying the evolutionary and ecological features of neoplasms.Nat Rev Cancer2017
28854180Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures.Nat Genet2017
28581503Between-region genetic divergence reflects the mode and tempo of tumor evolution.Nat Genet2017
27741350Measuring cancer evolution from the genome.J Pathol2017
26949746Cancer Evolution and the Limits of Predictability in Precision Cancer Medicine.Trends Cancer2016
27652316Functional versus non-functional intratumor heterogeneity in cancer.Mol Cell Oncol2016
27286795EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation.Neuro Oncol2016
26780609Identification of neutral tumor evolution across cancer types.Nat Genet2016
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Collaborators

Christina Curtis
Stanford University School of Medicine
Co-authored papers 9
Simon Tavar??
Irving Institute for Cancer Dynamics, Columbia University
Co-authored papers 6
Richard A Anderson
Co-authored papers 5
Louis Vermeulen
Oncode Institute
Co-authored papers 4
Charles Swanton
Francis Crick Institute
Co-authored papers 3
Jan Paul Medema
Oncode Institute
Co-authored papers 2
Daniele Ramazzotti
University of Milano-Bicocca
Co-authored papers 2
Peter M A Sloot
Institute for Advanced Study, University of Amsterdam.
Co-authored papers 2
David C Wedge
Manchester Cancer Research Centre, University of Manchester
Co-authored papers 2
John C Marioni
Cancer Research UK Cambridge Institute, University of Cambridge
Co-authored papers 2
Susana Banerjee
The Royal Marsden NHS Foundation Trust and Institute of Cancer Research
Co-authored papers 2
Nina Tunariu
The Institute of Cancer Research
Co-authored papers 2
Claire Palles
Institute of Cancer and Genomic Sciences, University of Birmingham
Co-authored papers 2
Michael F Press
Co-authored papers 2
Vincent Peter Collins
Mount Sinai Hospital
Co-authored papers 2
Marco Punta
Co-authored papers 2
Carlos Caldas
Cancer Research UK Cambridge Institute, University of Cambridge
Co-authored papers 1
Joost J C Verhoeff
University Medical Center Utrecht
Co-authored papers 1
Ville Mustonen
University of Helsinki
Co-authored papers 1
Giovanni Ciriello
University of Lausanne (UNIL)
Co-authored papers 1
Francesco Galimi
Co-authored papers 1
Roel G W Verhaak
Yale School of Medicine
Co-authored papers 1
Lev Naumov
Co-authored papers 1
Dan J Woodcock
University of Oxford
Co-authored papers 1
Shannon K McWeeney
Oregon Health & Science University, University of California Berkeley
Co-authored papers 1
Tijana Borovski
Cancer Center, University Medical Center Utrecht
Co-authored papers 1
Stefan Gr??f
Heart and Lung Research Institute, University of Cambridge
Co-authored papers 1
Clare Turnbull
Institute of Cancer Research
Co-authored papers 1
Rodrigo Dienstmann
Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus
Co-authored papers 1
Nuria Lopez-Bigas
Universitat Pompeu Fabra
Co-authored papers 1
Release 1.2