Author details

Full Name

Joseph LehÃ¡r

Affiliation

ORCID

Career Start Year

1990

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
31068700	Next-generation characterization of the Cancer Cell Line Encyclopedia.	Nature	2019
31840094	Quantifying neurologic disease using biosensor measurements in-clinic and in free-living settings in multiple sclerosis.	NPJ Digit Med	2019
30559381	Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.	Nature	2019
30304439	CANDI: an R package and Shiny app for annotating radiographs and evaluating computer-aided diagnosis.	Bioinformatics	2019
29381109	Natural Language-based Machine Learning Models for the Annotation of Clinical Radiology Reports.	Radiology	2018
30104767	Automated deep-neural-network surveillance of cranial images for acute neurologic events.	Nat Med	2018
28265066	Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf<sup>-/-</sup> mouse model.	Proc Natl Acad Sci U S A	2017
27659046	High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells.	Cancer Res	2016
26731447	Correction: Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages.	PLoS ONE	2016
26821252	Simulating Serial-Target Antibacterial Drug Synergies Using Flux Balance Analysis.	PLoS One	2016
26378449	Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages.	PLoS ONE	2015
26479923	High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response.	Nat Med	2015
26041706	A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity.	Sci Transl Med	2015
25002028	CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors.	Cancer Cell	2014
25036042	A meta-analysis approach for characterizing pan-cancer mechanisms of drug sensitivity in cell lines.	PLoS One	2014
24747911	Inhibiting Tankyrases sensitizes KRAS-mutant cancer cells to MEK inhibitors via FGFR2 feedback signaling.	Cancer Res	2014
24608574	Characterization of the novel and specific PI3KÎ± inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials.	Mol Cancer Ther	2014
23785035	FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection.	Science Translational Medicine	2013
23155392	RAD001 enhances the potency of BEZ235 to inhibit mTOR signaling and tumor growth.	PLoS ONE	2012
22460905	The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.	Nature	2012
21217751	Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection.	Nat Methods	2011
20531405	Chemical combinations elucidate pathway interactions and regulation relevant to Hepatitis C replication.	Molecular Systems Biology	2010
21050065	Identification of synergistic combinations of F508del cystic fibrosis transmembrane conductance regulator (CFTR) modulators.	Assay and Drug Development Technologies	2010
20532247	Recurrent, robust and scalable patterns underlie human approach and avoidance.	PLoS One	2010
20040268	Therapeutic selectivity and the multi-node drug target.		2009
19581876	Synergistic drug combinations tend to improve therapeutically relevant selectivity.	Nat Biotechnol	2009
18682705	High-order combination effects and biological robustness.	Molecular Systems Biology	2008
18936752	Combination chemical genetics.	Nat Chem Biol	2008
17332758	Chemical combination effects predict connectivity in biological systems.	Mol Syst Biol	2007
17198971	Multi-target therapeutics: when the whole is greater than the sum of the parts.	Drug Discovery Today	2007
12799470	Systematic discovery of multicomponent therapeutics.	Proc Natl Acad Sci U S A	2003
12808457	PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.	Nat Genet	2003
18278020	Galaxy mass deduced from the structure of Einstein ring MG1654+1346.	Nature	1990