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Author Details

Greg J Towers
University College London
1995
122
53
Kirsten Obernier (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37507296Molecular frustration: a hypothesis for regulation of viral infections.Trends Microbiol2024
36693093SARS-CoV-2 evolution influences GBP and IFITM sensitivity.Proc Natl Acad Sci U S A2023
37491597Plasmapheresis to remove amyloid fibrin(ogen) particles for treating the post-COVID-19 condition.Cochrane Database Syst Rev2023
37738970SARS-CoV-2 variants evolve convergent strategies to remodel the host response.Cell2023
36653446SARS-CoV-2 variant biology: immune escape, transmission and fitness.Nat Rev Microbiol2023
35332335Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2.Nature2022
35812362Anti-type I interferon antibodies as a cause of severe COVID-19.Fac Rev2022
35999696Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spike.EMBO Rep2022
36289397Evasion of cGAS and TRIM5 defines pandemic HIV.Nat Microbiol2022
35073912HIV-2/SIV Vpx antagonises NF-κB activation by targeting p65.Retrovirology2022
35012962Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19.Life Sci Alliance2022
34942634Evolution of enhanced innate immune evasion by SARS-CoV-2.Nature2022
34101213SARS-CoV-2 sensing by RIG-I and MDA5 links epithelial infection to macrophage inflammation.EMBO J2021
33791702Characterisation of B.1.1.7 and Pangolin coronavirus spike provides insights on the evolutionary trajectory of SARS-CoV-2.bioRxiv2021
34541469STING nuclear partners contribute to innate immune signaling responses.iScience2021
34075384Plitidepsin has a positive therapeutic index in adult patients with COVID-19 requiring hospitalization.medRxiv2021
34127972Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant.bioRxiv2021
32539931Hepatitis C virus exploits cyclophilin A to evade PKR.Elife2020
33144375<i>In Vivo</i> Emergence of a Novel Protease Inhibitor Resistance Signature in HIV-1 Matrix.mBio2020
33300875HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport.Elife2020
32852081Disrupting HIV-1 capsid formation causes cGAS sensing of viral DNA.EMBO J2020
32553106MxB sensitivity of HIV-1 is determined by a highly variable and dynamic capsid surface.Elife2020
30834893Identifying a nuclear passport for HIV.Elife2019
31970199Lentiviral Vector Production Titer Is Not Limited in HEK293T by Induced Intracellular Innate Immunity.Mol Ther Methods Clin Dev2019
31615393ChromaClade: combined visualisation of phylogenetic and sequence data.BMC Evol Biol2019
30867315Kinetics of Early Innate Immune Activation during HIV-1 Infection of Humanized Mice.J Virol2019
31156613Variable Baseline <i>Papio cynocephalus</i> Endogenous Retrovirus (PcEV) Expression Is Upregulated in Acutely SIV-Infected Macaques and Correlated to STAT1 Expression in the Spleen.Front Immunol2019
29223806Preventing the N-terminal processing of human interferon α-2b and its chimeric derivatives expressed in Escherichia coli.Bioorg Chem2018
29848441IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis.Elife2018
30061100KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control.EMBO Rep2018
30416070Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.Cell Stem Cell2018
30503508Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling.Cell Host Microbe2018
29491158Virulent Poxviruses Inhibit DNA Sensing by Preventing STING Activation.J Virol2018
29084722DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of macrophages.EMBO J2018
29056936Are Evolution and the Intracellular Innate Immune System Key Determinants in HIV Transmission?Front Immunol2017
28122869A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages.EMBO J2017
26679998Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis.J Biol Chem2016
27455304Infection Counter: Automated Quantification of in Vitro Virus Replication by Fluorescence Microscopy.Viruses2016
27440884Nonhuman TRIM5 Variants Enhance Recognition of HIV-1-Infected Cells by CD8+ T Cells.J Virol2016
27509857HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis.Nature2016
26123213Positive Selection Analysis of Overlapping Reading Frames Is Invalid.AIDS Res Hum Retroviruses2015
26101372TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.EMBO J2015
24424502Gene therapy strategies to exploit TRIM derived restriction factors against HIV-1.Viruses2014
25011104Interactions between HIV-1 and the cell-autonomous innate immune system.Cell Host Microbe2014
25162725Early biodistribution and persistence of a protective live attenuated SIV vaccine elicits localised innate responses in multiple lymphoid tissues.PLoS One2014
25132672Endoplasmic reticulum degradation-enhancing α-mannosidase-like protein 1 targets misfolded HLA-B27 dimers for endoplasmic reticulum-associated degradation.Arthritis Rheumatol2014
24525292A model for cofactor use during HIV-1 reverse transcription and nuclear entry.Curr Opin Virol2014
24656066Vpx complementation of 'non-macrophage tropic' R5 viruses reveals robust entry of infectious HIV-1 cores into macrophages.Retrovirology2014
23152371Upregulation of TRIM5α gene expression after live-attenuated simian immunodeficiency virus vaccination in Mauritian cynomolgus macaques, but TRIM5α genotype has no impact on virus acquisition or vaccination outcome.J Gen Virol2013
24067975Tetherin restricts herpes simplex virus 1 and is antagonized by glycoprotein M.J Virol2013
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Collaborators

University College London
Co-authored papers 14
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Co-authored papers 13
J. David Gladstone Institutes
Co-authored papers 11
University College London
Co-authored papers 10
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Co-authored papers 10
University College London
Co-authored papers 7
University College London
Co-authored papers 6
J. David Gladstone Institutes
Co-authored papers 6
University of California San Francisco
Co-authored papers 6
University of California San Francisco
Co-authored papers 6
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 5
Icahn School of Medicine at Mount Sinai
Co-authored papers 5
Icahn School of Medicine at Mount Sinai
Co-authored papers 5
J. David Gladstone Institutes
Co-authored papers 4
Institute of Molecular Systems Biology, ETH Zurich
Co-authored papers 4
University of California, San Francisco
Co-authored papers 4
J. David Gladstone Institutes
Co-authored papers 4
University of Ottawa
Co-authored papers 4
J. David Gladstone Institutes
Co-authored papers 4
University of New South Wales
Co-authored papers 4
Columbia University
Co-authored papers 4
University of California, University of California San Francisco
Co-authored papers 4
The Rockefeller University
Co-authored papers 4
University College London
Co-authored papers 4
University of Cambridge
Co-authored papers 3
University of California San Francisco
Co-authored papers 3
Massachusetts Institute of Technology
Co-authored papers 3
University of California San Francisco
Co-authored papers 3
European Bioinformatics Institute
Co-authored papers 3
IrsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias i Pujol
Co-authored papers 3