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Author Details
Full Name
Greg J Towers
Affiliation
University College London
ORCID
Career Start Year
1995
Papers
122
H Index
53
Expertise
CM4AI Collaborator
Kirsten Obernier (CM4AI)
PMID
Paper Title
Journal Title
Published Year
37507296
Molecular frustration: a hypothesis for regulation of viral infections.
Trends Microbiol
2024
36693093
SARS-CoV-2 evolution influences GBP and IFITM sensitivity.
Proc Natl Acad Sci U S A
2023
37491597
Plasmapheresis to remove amyloid fibrin(ogen) particles for treating the post-COVID-19 condition.
Cochrane Database Syst Rev
2023
37738970
SARS-CoV-2 variants evolve convergent strategies to remodel the host response.
Cell
2023
36653446
SARS-CoV-2 variant biology: immune escape, transmission and fitness.
Nat Rev Microbiol
2023
35332335
Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2.
Nature
2022
35812362
Anti-type I interferon antibodies as a cause of severe COVID-19.
Fac Rev
2022
35999696
Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spike.
EMBO Rep
2022
36289397
Evasion of cGAS and TRIM5 defines pandemic HIV.
Nat Microbiol
2022
35073912
HIV-2/SIV Vpx antagonises NF-κB activation by targeting p65.
Retrovirology
2022
35012962
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19.
Life Sci Alliance
2022
34942634
Evolution of enhanced innate immune evasion by SARS-CoV-2.
Nature
2022
34101213
SARS-CoV-2 sensing by RIG-I and MDA5 links epithelial infection to macrophage inflammation.
EMBO J
2021
33791702
Characterisation of B.1.1.7 and Pangolin coronavirus spike provides insights on the evolutionary trajectory of SARS-CoV-2.
bioRxiv
2021
34541469
STING nuclear partners contribute to innate immune signaling responses.
iScience
2021
34075384
Plitidepsin has a positive therapeutic index in adult patients with COVID-19 requiring hospitalization.
medRxiv
2021
34127972
Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant.
bioRxiv
2021
32539931
Hepatitis C virus exploits cyclophilin A to evade PKR.
Elife
2020
33144375
<i>In Vivo</i> Emergence of a Novel Protease Inhibitor Resistance Signature in HIV-1 Matrix.
mBio
2020
33300875
HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport.
Elife
2020
32852081
Disrupting HIV-1 capsid formation causes cGAS sensing of viral DNA.
EMBO J
2020
32553106
MxB sensitivity of HIV-1 is determined by a highly variable and dynamic capsid surface.
Elife
2020
30834893
Identifying a nuclear passport for HIV.
Elife
2019
31970199
Lentiviral Vector Production Titer Is Not Limited in HEK293T by Induced Intracellular Innate Immunity.
Mol Ther Methods Clin Dev
2019
31615393
ChromaClade: combined visualisation of phylogenetic and sequence data.
BMC Evol Biol
2019
30867315
Kinetics of Early Innate Immune Activation during HIV-1 Infection of Humanized Mice.
J Virol
2019
31156613
Variable Baseline <i>Papio cynocephalus</i> Endogenous Retrovirus (PcEV) Expression Is Upregulated in Acutely SIV-Infected Macaques and Correlated to STAT1 Expression in the Spleen.
Front Immunol
2019
29223806
Preventing the N-terminal processing of human interferon α-2b and its chimeric derivatives expressed in Escherichia coli.
Bioorg Chem
2018
29848441
IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis.
Elife
2018
30061100
KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control.
EMBO Rep
2018
30416070
Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.
Cell Stem Cell
2018
30503508
Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling.
Cell Host Microbe
2018
29491158
Virulent Poxviruses Inhibit DNA Sensing by Preventing STING Activation.
J Virol
2018
29084722
DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of macrophages.
EMBO J
2018
29056936
Are Evolution and the Intracellular Innate Immune System Key Determinants in HIV Transmission?
Front Immunol
2017
28122869
A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages.
EMBO J
2017
26679998
Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis.
J Biol Chem
2016
27455304
Infection Counter: Automated Quantification of in Vitro Virus Replication by Fluorescence Microscopy.
Viruses
2016
27440884
Nonhuman TRIM5 Variants Enhance Recognition of HIV-1-Infected Cells by CD8+ T Cells.
J Virol
2016
27509857
HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis.
Nature
2016
26123213
Positive Selection Analysis of Overlapping Reading Frames Is Invalid.
AIDS Res Hum Retroviruses
2015
26101372
TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.
EMBO J
2015
24424502
Gene therapy strategies to exploit TRIM derived restriction factors against HIV-1.
Viruses
2014
25011104
Interactions between HIV-1 and the cell-autonomous innate immune system.
Cell Host Microbe
2014
25162725
Early biodistribution and persistence of a protective live attenuated SIV vaccine elicits localised innate responses in multiple lymphoid tissues.
PLoS One
2014
25132672
Endoplasmic reticulum degradation-enhancing α-mannosidase-like protein 1 targets misfolded HLA-B27 dimers for endoplasmic reticulum-associated degradation.
Arthritis Rheumatol
2014
24525292
A model for cofactor use during HIV-1 reverse transcription and nuclear entry.
Curr Opin Virol
2014
24656066
Vpx complementation of 'non-macrophage tropic' R5 viruses reveals robust entry of infectious HIV-1 cores into macrophages.
Retrovirology
2014
23152371
Upregulation of TRIM5α gene expression after live-attenuated simian immunodeficiency virus vaccination in Mauritian cynomolgus macaques, but TRIM5α genotype has no impact on virus acquisition or vaccination outcome.
J Gen Virol
2013
24067975
Tetherin restricts herpes simplex virus 1 and is antagonized by glycoprotein M.
J Virol
2013
1 - 50 of 122
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Co-authored papers
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J. David Gladstone Institutes
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University of California San Francisco
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Kris M White
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
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Adolfo Garc??a-Sastre
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Pedro Beltrao
Institute of Molecular Systems Biology, ETH Zurich
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Manisha Ummadi
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Danielle L Swaney
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