Skip to Main Content

Author Details

Peter J McHugh
MRC Weatherall Institute of Molecular Medicine, University of Oxford
1993
72
37
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36541070WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures.EMBO J2023
36237323Editorial: Targeting DNA repair and the DNA damage response: Beyond the standard PI3 kinase-like kinases.Front Oncol2022
32518175Genetic and functional insights into CDA-I prevalence and pathogenesis.J Med Genet2021
33767446Neuronal enhancers are hotspots for DNA single-strand break repair.Nature2021
34387696Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.Nucleic Acids Res2021
34387694A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.Nucleic Acids Res2021
34316696The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core.NAR Cancer2021
32271747XPF-ERCC1: Linchpin of DNA crosslink repair.PLoS Genet2020
31989516Analysis of DNA Interstrand Cross-Links and their Repair by Modified Comet Assay.Methods Mol Biol2020
32999459Repeat expansions confer WRN dependence in microsatellite-unstable cancers.Nature2020
32866775The SNM1A DNA repair nuclease.DNA Repair (Amst)2020
30510168Antiviral activity of bone morphogenetic proteins and activins.Nat Microbiol2019
31497827Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors.Chem Commun (Camb)2019
31380542A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A.Org Biomol Chem2019
31127293Microhomologies are prevalent at Cas9-induced larger deletions.Nucleic Acids Res2019
29271657In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.J Med Chem2018
29924986Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading.Cell Rep2018
31414040Squaramide-Based 5'-Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A.ChemistrySelect2018
29467415PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation.Nat Commun2018
29739952Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma.Sci Rep2018
28628639Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.PLoS One2017
28279982A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1.Genes Dev2017
28607004RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks.EMBO J2017
26805042The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins.Trends Biochem Sci2016
27636878Mgm101: A double-duty Rad52-like protein.Cell Cycle2016
27121860Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo.Chem Commun (Camb)2016
26807646EXD2 promotes homologous recombination by facilitating DNA end resection.Nat Cell Biol2016
25505141CSB interacts with SNM1A and promotes DNA interstrand crosslink processing.Nucleic Acids Res2015
26482303Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers.Antimicrob Agents Chemother2015
26582912The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities.Nucleic Acids Res2015
23982883XPF protein levels determine sensitivity of malignant melanoma cells to oxaliplatin chemotherapy: suitability as a biomarker for patient selection.Int J Cancer2014
23352139A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.Chem Biol2013
24360959A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.Cell Rep2013
22912599Components of a Fanconi-like pathway control Pso2-independent DNA interstrand crosslink repair in yeast.PLoS Genet2012
23344082Quantitative analysis of survivin protein expression and its therapeutic depletion by an antisense oligonucleotide in human lung tumors.Mol Ther Nucleic Acids2012
22692201Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases.J Biol Chem2012
22895051A prototypical Fanconi anemia pathway in lower eukaryotes?Cell Cycle2012
21398521Human HEL308 localizes to damaged replication forks and unwinds lagging strand structures.J Biol Chem2011
22101340Orchestrating the nucleases involved in DNA interstrand cross-link (ICL) repair.Cell Cycle2011
21896658Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair.Genes Dev2011
21343337Pathways for Holliday junction processing during homologous recombination in Saccharomyces cerevisiae.Mol Cell Biol2011
20175117The SNM1/Pso2 family of ICL repair nucleases: from yeast to man.Environ Mol Mutagen2010
21135142The Ino80 chromatin-remodeling complex restores chromatin structure during UV DNA damage repair.J Cell Biol2010
21041181Tumor survivin is downregulated by the antisense oligonucleotide LY2181308: a proof-of-concept, first-in-human dose study.Clin Cancer Res2010
19550156Apollo: a healer of the genome?Cell Cycle2009
19805513XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.Mol Cell Biol2009
18006388Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants.DNA Repair (Amst)2008
19047122Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.Clin Cancer Res2008
17096663DNA interstrand cross-link repair in Saccharomyces cerevisiae.FEMS Microbiol Rev2007
17938264DNA sequence selective adenine alkylation, mechanism of adduct repair, and in vivo antitumor activity of the novel achiral seco-amino-cyclopropylbenz[e]indolone analogue of duocarmycin AS-I-145.Mol Cancer Ther2007
  • 1 - 50 of 72

Recommended Authors

Marc Wiedner
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Career Start Year 2013
Number of shared co-authors 2
Natalie Saini
Medical University of South Carolina
Career Start Year 2012
Number of shared co-authors 0
David Gallo
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Career Start Year 2010
Number of shared co-authors 0
Jianfeng Li
Mitchell Cancer Institute, University of South Alabama
Career Start Year 2008
Number of shared co-authors 5
Abdelghani Mazouzi
Netherlands Cancer Institute
Career Start Year 2005
Number of shared co-authors 1
Ga??lle Legube
CNRS, Universite de Toulouse
Career Start Year 2002
Number of shared co-authors 3
Joanna I Loizou
Center for Cancer Research, Comprehensive Cancer Centre, Medical University of Vienna
Career Start Year 2002
Number of shared co-authors 2
Kyle M Miller
The University of Texas at Austin
Career Start Year 2001
Number of shared co-authors 1
Hans Hombauer
German Cancer Research Center (DKFZ)
Career Start Year 2000
Number of shared co-authors 1
Junjie Chen
The University of Texas MD Anderson Cancer Center
Career Start Year 2000
Number of shared co-authors 1
Xiaolan Zhao
Memorial Sloan-Kettering Cancer Center
Career Start Year 1998
Number of shared co-authors 2
Thomas Helleday
The University of Sheffield
Career Start Year 1998
Number of shared co-authors 4
Kenji Shimada
Friedrich Miescher Institute for Biomedical Research
Career Start Year 1997
Number of shared co-authors 4
Agata Smogorzewska
Instituto de Investigacion Sanitaria Hospital 12 de Octubre (imas12)
Career Start Year 1997
Number of shared co-authors 1
Simon J Boulton
The Francis Crick Institute
Career Start Year 1996
Number of shared co-authors 2
Daniel Durocher
The Lunenfeld-Tannenbaum Research Institute, Mount Sinai Hospital
Career Start Year 1995
Number of shared co-authors 3
Grant W Brown
University of Toronto, 1 King's College Circle
Career Start Year 1991
Number of shared co-authors 0
John W Phillips
University of California los angeles
Career Start Year 1988
Number of shared co-authors 0
Stephen P Jackson
Mission Therapeutics Ltd. Glenn Berge Building
Career Start Year 1987
Number of shared co-authors 2
Robert W Sobol
University of South Alabama
Career Start Year 1987
Number of shared co-authors 5
Bennett Van Houten
UPMC-Hillman Cancer Center, University of Pittsburgh
Career Start Year 1982
Number of shared co-authors 3
Wolf-Dietrich Heyer
University of California davis
Career Start Year 1982
Number of shared co-authors 0
Stephen J Elledge
Howard Hughes Medical Institute, Brigham and Women's Hospital, Harvard Medical School
Career Start Year 1982
Number of shared co-authors 3
Dmitry A Gordenin
National Institute of Environmental Health Sciences (NIEHS)
Career Start Year 1981
Number of shared co-authors 0
Yves Pommier
Center for Cancer Research, National Cancer Institute
Career Start Year 1980
Number of shared co-authors 3
Raymond J Monnat
University of Washington School of Medicine
Career Start Year 1978
Number of shared co-authors 1
Rodney Rothstein
Columbia University Vagelos College of Physicians & Surgeons
Career Start Year 1977
Number of shared co-authors 1
Leona D Samson
Massachusetts Institute of Technology
Career Start Year 1977
Number of shared co-authors 1
Richard D Kolodner
Ludwig Institute for Cancer Research San Diego Branch
Career Start Year 1972
Number of shared co-authors 4
Thomas E Wilson
University of Michigan ann arbor
Career Start Year 1955
Number of shared co-authors 0

Collaborators

Opher Gileadi
Structural Genomics Consortium Karolinska Institute Stockholm Sweden.
Co-authored papers 11
Sovan Sarkar
CRUK MRC Oxford Institute for Radiation Oncology, University of Oxford
Co-authored papers 6
Adrian L Harris
University of Oxford
Co-authored papers 3
Jan Rehwinkel
MRC Weatherall Institute of Molecular Medicine, University of Oxford
Co-authored papers 2
Raymond T Chung
Massachusetts General Hospital and Harvard Medical School
Co-authored papers 1
Nikhil Bhagwat
Howard Hughes Medical Institute, University of California at Davis
Co-authored papers 1
No??mi B A Roy
MRC Weatherall Institute of Molecular Medicine, University of Oxford
Co-authored papers 1
Fred van Leeuwen
Netherlands Cancer Institute, University of Amsterdam
Co-authored papers 1
Robert L Walker
Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 1
Ajit Jadhav
Co-authored papers 1
Haico van Attikum
Leiden University Medical Center
Co-authored papers 1
Eleni Giannoulatou
Co-authored papers 1
Alan D D'Andrea
Dana-Farber Cancer Institute
Co-authored papers 1
Kiran Garimella
Co-authored papers 1
Francesc Castro-Giner
University of Basel and University Hospital Basel
Co-authored papers 1
Marijke Pool
Leiden University Medical Center
Co-authored papers 1
Tibor van Welsem
Netherlands Cancer Institute
Co-authored papers 1
Han-Yu Shih
National Eye Institute, National Institutes of Health
Co-authored papers 1
Rohith Srivas
Amgen Inc.
Co-authored papers 1
Tanya T Paull
University of Texas at Austin
Co-authored papers 1
Katherine Licon
University of California San Diego
Co-authored papers 1
Syed Haider
Institute of Cancer Research
Co-authored papers 1
Vip Viprakasit
Co-authored papers 1
Adam J Bass
Co-authored papers 1
Gemma F Codner
Medical Research Council Harwell Institute
Co-authored papers 1
Johann S de Bono
The Institute for Cancer Research
Co-authored papers 1
Erik Malta
Leiden University Medical Center
Co-authored papers 1
Michael E Ward
National Institute of Neurological, National Institutes of Health (NIH)
Co-authored papers 1
Michael A Eberle
Illumina Inc.
Co-authored papers 1
Anne-Ruxandra Carvunis
University of Pittsburgh School of Medicine.
Co-authored papers 1
Release 1.2