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Author Details

Robert K Bradley
Fred Hutchinson Cancer Research Center, University of Washington
1998
70
38
PMIDPaper TitleJournal TitlePublished Year
36627445RNA splicing dysregulation and the hallmarks of cancer.Nat Rev Cancer2023
37502871DUX4 is a common driver of immune evasion and immunotherapy failure in metastatic cancers.bioRxiv2023
37137707Recursive splicing discovery using lariats in total RNA sequencing.Life Sci Alliance2023
37166992The proto-oncogene SRC phosphorylates cGAS to inhibit an antitumor immune response.JCI Insight2023
37396617pgMAP: a pipeline to enable guide RNA read mapping from dual-targeting CRISPR screens.ArXiv2023
36563682Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia.Cancer Cell2023
35241838Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells.Nat Biotechnol2022
34861039Coordinated missplicing of TMEM14C and ABCB7 causes ring sideroblast formation in SF3B1-mutant myelodysplastic syndrome.Blood2022
33473122Short H2A histone variants are expressed in cancer.Nat Commun2021
33846634Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition.Nat Genet2021
33527899Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia.Elife2021
34880103Nonsense-mediated mRNA decay uses complementary mechanisms to suppress mRNA and protein accumulation.Life Sci Alliance2021
34469736Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genome.Cell Rep2021
34568833<i>ZBTB33</i> is mutated in clonal hematopoiesis and myelodysplastic syndromes and impacts RNA splicing.Blood Cancer Discov2021
34171309Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.Cell2021
34285073Characterization of neoantigen-specific T cells in cancer resistant to immune checkpoint therapies.Proc Natl Acad Sci U S A2021
34373451Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer.Nat Commun2021
33404013The origins and consequences of <i>UPF1</i> variants in pancreatic adenosquamous carcinoma.Elife2021
32559497Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer.Cancer Cell2020
32001512Recurrent SRSF2 mutations in MDS affect both splicing and NMD.Genes Dev2020
31961934Rare and private spliceosomal gene mutations drive partial, complete, and dual phenocopies of hotspot alterations.Blood2020
31911676RNA isoform screens uncover the essentiality and tumor-suppressor activity of ultraconserved poison exons.Nat Genet2020
32640014Single-cell genomics reveals the genetic and molecular bases for escape from mutational epistasis in myeloid neoplasms.Blood2020
32278354Transgenic mice expressing tunable levels of DUX4 develop characteristic facioscapulohumeral muscular dystrophy-like pathophysiology ranging in severity.Skelet Muscle2020
30644821Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of facioscapulohumeral muscular dystrophy.Elife2019
31327741DUX4 Suppresses MHC Class I to Promote Cancer Immune Evasion and Resistance to Checkpoint Blockade.Dev Cell2019
31434678RNA components of the spliceosome regulate tissue- and cancer-specific alternative splicing.Genome Res2019
31578525Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis.Nature2019
31597964Spliceosomal disruption of the non-canonical BAF complex in cancer.Nature2019
30842218The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulation.Genes Dev2019
29681544Dissecting the Contributions of Cooperating Gene Mutations to Cancer Phenotypes and Drug Responses with Patient-Derived iPSCs.Stem Cell Reports2018
30107174Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.Cancer Cell2018
30322915Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene <i>U2af1</i>.Proc Natl Acad Sci U S A2018
30388411Exon Junction Complex Shapes the Transcriptome by Repressing Recursive Splicing.Mol Cell2018
29666160Most human introns are recognized via multiple and tissue-specific branchpoints.Genes Dev2018
27694897Systematic and functional characterization of novel androgen receptor variants arising from alternative splicing in the ligand-binding domain.Oncogene2017
28669802The RNA Surveillance Factor UPF1 Represses Myogenesis via Its E3 Ubiquitin Ligase Activity.Mol Cell2017
28717044Congenital myotonic dystrophy-an RNA-mediated disease across a developmental continuum.Genes Dev2017
27282250RNA splicing factors as oncoproteins and tumour suppressors.Nat Rev Cancer2016
28171552Model systems of DUX4 expression recapitulate the transcriptional profile of FSHD cells.Hum Mol Genet2016
27646533Translational plasticity facilitates the accumulation of nonsense genetic variants in the human population.Genome Res2016
27776121Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival.PLoS Genet2016
27151974Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesis.Genes Dev2016
27270779Erratum: Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins.Nat Med2016
27135740Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins.Nat Med2016
25267526U2AF1 mutations alter splice site recognition in hematological malignancies.Genome Res2015
28843286Integrative Clinical Genomics of Advanced Prostate Cancer.Cell2015
26554309Expression of androgen receptor splice variants in clinical breast cancers.Oncotarget2015
26113877Widespread intron retention diversifies most cancer transcriptomes.Genome Med2015
25965569SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition.Cancer Cell2015
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Collaborators

Heidi Dvinge
University of Wisconsin School of Medicine and Public Health
Co-authored papers 11
Ian Holmes
University of California berkeley
Co-authored papers 8
Stephen R Plymate
University of Washington
Co-authored papers 4
Jean-Baptiste Micol
INSERM U7, Universite Paris-Saclay
Co-authored papers 4
Lior Pachter
Co-authored papers 4
Alice H Berger
Fred Hutchinson Cancer Research Center
Co-authored papers 4
Yu Chen
School of Pharmacy, University of Wisconsin-Madison
Co-authored papers 3
Peter S Nelson
Fred Hutchinson Cancer Center
Co-authored papers 3
Camille Lobry
INSERM U1170, Universite Paris Saclay
Co-authored papers 3
Gerhardt Attard
The Institute of Cancer Research
Co-authored papers 2
Colin C Pritchard
University of Washington, USA Brotman Baty Institute for Precision Medicine
Co-authored papers 2
Glenn C Gaviola
Veterans Affairs Medical Center
Co-authored papers 2
Joaquin Mateo
Vall d'Hebron Institute of Oncology, Vall d'Hebron University Hospital Campus
Co-authored papers 2
Jeremy C Durack
Memorial Sloan Kettering Cancer Center
Co-authored papers 2
Christopher B Burge
Co-authored papers 2
Michael J Morris
Memorial Sloan Kettering Cancer Center
Co-authored papers 2
Scott A Tomlins
Rogel Cancer Center, University of Michigan Medical School ann arbor
Co-authored papers 2
Kenneth Eng
Caryl and Israel Englander Institute for Precision Medicine
Co-authored papers 2
Jake Vinson
Prostate Cancer Clinical Trials Consortium (PCCTC)
Co-authored papers 2
Bruce Montgomery
Fred Hutchinson Cancer Center, University of Washington
Co-authored papers 2
Christine Brennan
University of Michigan ann arbor
Co-authored papers 2
Levi A Garraway
Broad Institute of Harvard and MIT
Co-authored papers 2
Manaswi Gupta
Broad Institute of Massachusetts Institute of Technology and Harvard
Co-authored papers 2
Rosina T Lis
National Cancer Institute
Co-authored papers 2
Charles L Sawyers
Memorial Sloan Kettering Cancer Center
Co-authored papers 2
Pankaj Vats
Michigan Center for Translational Pathology, University of Michigan ann arbor
Co-authored papers 2
Dan R Robinson
Michigan Center for Translational Pathology, University of Michigan ann arbor
Co-authored papers 2
Elisabeth I Heath
Karmanos Cancer Center, Wayne State University
Co-authored papers 2
Susana Miranda
The Institute of Cancer Research
Co-authored papers 2
Michael B Eisen
Howard Hughes Medical Institute, University of California Berkeley
Co-authored papers 2
Release 1.2