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Author Details

Mark R Sanderson
King's College
1978
46
28
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
32634310Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.J Med Chem2020
29968711Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase.Nat Commun2018
27050128Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae and comparison with a related Streptococcus pneumoniae complex.Acta Crystallogr D Struct Biol2016
27655731Exploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolones.Open Biol2016
23965305Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport.Nucleic Acids Res2013
24225024Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction.Open Biol2013
22955930In support of the BMRB.Nat Struct Mol Biol2012
20596531Structural basis of gate-DNA breakage and resealing by type II topoisomerases.PLoS One2010
20532212The SOCS-box of HIV-1 Vif interacts with ElonginBC by induced-folding to recruit its Cul5-containing ubiquitin ligase complex.PLoS Pathog2010
19448616Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases.Nat Struct Mol Biol2009
18787651The difficult case of crystallization and structure solution for the ParC55 breakage-reunion domain of topoisomerase IV from Streptococcus pneumoniae.PLoS One2008
17375187Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target.PLoS One2007
15659402Novel symmetric and asymmetric DNA scission determinants for Streptococcus pneumoniae topoisomerase IV and gyrase are clustered at the DNA breakage site.J Biol Chem2005
14729337Redefinition of the cleavage sites of DNase I on the nucleosome core particle.J Mol Biol2004
12443042Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods.J Enzyme Inhib Med Chem2002
11697728Solution structure, hydrodynamics and thermodynamics of the UvrB C-terminal domain.J Biomol Struct Dyn2001
10631326Crystal structure of Escherichia coli UvrB C-terminal domain, and a model for UvrB-uvrC interaction.FEBS Lett2000
10920199A DNA-porphyrin minor-groove complex at atomic resolution: the structural consequences of porphyrin ruffling.Proc Natl Acad Sci U S A2000
10543876Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954).J Med Chem1999
10371161NMR assignments and secondary structure of the UvrC binding domain of UvrB.FEBS Lett1999
9989588Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir.FEBS Lett1999
9715911Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.Proteins1998
9747715Herpesviral thymidine kinases: laxity and resistance by design.J Gen Virol1998
97841095-Substituted pyrimidines with a 1,5-anhydro-2, 3-dideoxy-D-arabino-hexitol moiety at N-1: synthesis, antiviral activity, conformational analysis, and interaction with viral thymidine kinase.J Med Chem1998
9450049Structure-specificity features of HSV-1 thymidine kinases.Biochem Soc Trans1997
8781240Crystallographic methods and protocols. Introduction.Methods Mol Biol1996
8781242Preliminary characterization of crystals.Methods Mol Biol1996
7552712Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir.Nat Struct Biol1995
8302836Crystal structure of a disulfide-linked "trefoil" motif found in a large family of putative growth factors.Proc Natl Acad Sci U S A1994
1640462Crystal structure of a berenil-d(CGCAAATTTGCG) complex. An example of drug-DNA recognition based on sequence-dependent structural features.J Mol Biol1992
1883321Structural aspects of protein-DNA recognition.Biochem J1991
2216724Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study.Nucleic Acids Res1990
2175678The crystal structure of the catalytic domain of the site-specific recombination enzyme gamma delta resolvase at 2.7 A resolution.Cell1990
2323343Crystal structure of a berenil-dodecanucleotide complex: the role of water in sequence-specific ligand binding.EMBO J1990
2395870Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG).Proc Natl Acad Sci U S A1990
2553982Preparation of heavy-atom derivatives using site-directed mutagenesis. Introduction of cysteine residues into gamma delta resolvase.J Mol Biol1989
2928304Crystal lattice packing is important in determining the bend of a DNA dodecamer containing an adenine tract.Proc Natl Acad Sci U S A1989
2494346Preliminary crystallographic data for NAD(P)H quinone reductase isolated from the Walker 256 rat carcinoma cell line.J Mol Biol1989
2832946Genetic and crystallographic studies of the 3',5'-exonucleolytic site of DNA polymerase I.Science1988
3194400Cocrystal structure of an editing complex of Klenow fragment with DNA.Proc Natl Acad Sci U S A1988
2845104Purification and crystallization of thymidine kinase from herpes simplex virus type 1.J Mol Biol1988
3331343Structural studies of Klenow fragment: an enzyme with two active sites.Cold Spring Harb Symp Quant Biol1987
3017719Conformational analysis of the octamer d(G-G-C-C-G-G-C-C) in aqueous solution. A one-dimensional and two-dimensional proton NMR study at 300 MHz and 500 MHz.Eur J Biochem1986
6856458Assignment of non-exchangeable base proton and H1' resonances of a deoxyoctanucleoside heptaphosphate d(G-G-C*-C*-G-G-C-C) by using the nuclear Overhauser effect.Nucleic Acids Res1983
5188889-beta-D-Arabinofuranosyl-8-n-butylaminoadenine, a C-8 substituted nucleoside in the anti conformation. Crystallographic and NMR studies.Biochim Biophys Acta1979
724521A 1:2 crystalline complex of ApA:proflavine: a model for binding to single-stranded regions in RNA.Nucleic Acids Res1978
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Collaborators

Imperial College London
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The Medical Research Council Biomedical NMR Centre, The Francis Crick Institute
Co-authored papers 2
University of Oxford
Co-authored papers 2
University of Pittsburgh
Co-authored papers 2
University of California San Francisco
Co-authored papers 1
University of Illinois
Co-authored papers 1
and Center for Structural Biology, Vanderbilt University
Co-authored papers 1
Technische Universitat Munchen (TUM)
Co-authored papers 1
University of Bristol
Co-authored papers 1
The University of Manchester
Co-authored papers 1
Rutgers University
Co-authored papers 1
Center for Integrated Protein Science, Technische Universitat Munchen
Co-authored papers 1
Leicester Institute of Structural and Chemical Biology, University of Leicester
Co-authored papers 1
University of Texas Southwestern Medical Center
Co-authored papers 1
The University of Sheffield
Co-authored papers 1
Institute of Systems, The University of Liverpool
Co-authored papers 1
Institute of Integrative Biology, University of Liverpool
Co-authored papers 1
Columbia University
Co-authored papers 1
National Institutes of Health
Co-authored papers 1
Zernike Institute for Advanced Materials, University of Groningen
Co-authored papers 1
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University of Oxford
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University of Cambridge
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Carnegie Mellon University
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Carnegie Mellon University
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Institute for Protein Research, Osaka University
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Sichuan University
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The Francis Crick Institute
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Shinshu University School of Medicine
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