Author details

Full Name

Orly Dym

Affiliation

Weizmann Institute of Science

ORCID

Career Start Year

1995

Papers

H Index

Expertise

CM4AI Collaborator

Andrej Sali (CM4AI)

PMID	Paper Title	Journal Title	Published Year
37787609	PGR5-LIKE PHOTOSYNTHETIC PHENOTYPE1A redox states alleviate photoinhibition during changes in light intensity.	Plant Physiol	2024
36808692	Design of a stable human acid-Î²-glucosidase: towards improved Gaucher disease therapy and mutation classification.	FEBS J	2023
37860961	The impact of molecular variants, crystallization conditions and the space group on ligand-protein complexes: a case study on bacterial phosphotriesterase.	Acta Crystallogr D Struct Biol	2023
37561584	Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer's disease phenotype in mice.	J Clin Invest	2023
37526947	Diversity of CysD domains in gel-forming mucins.	FEBS J	2023
37452148	Phylogeny and biogeography of the algal DMS-releasing enzyme in the global ocean.	ISME Commun	2023
37285353	gUMI-BEAR, a modular, unsupervised population barcoding method to track variants and evolution at high resolution.	PLoS One	2023
37385581	Stable Mammalian Serum Albumins Designed for Bacterial Expression.	J Mol Biol	2023
37094144	Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase.	Proc Natl Acad Sci U S A	2023
35102291	Computationally designed dual-color MRI reporters for noninvasive imaging of transgene expression.	Nat Biotechnol	2022
35359497	The identification and characterization of an oxalyl-CoA synthetase from grass pea (<i>Lathyrus sativus</i> L.).	RSC Chem Biol	2022
34400835	SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution.	Nat Microbiol	2021
33771569	A Molecular Lid Mechanism of K<sup>+</sup> Channel Blocker Action Revealed by a Cone Peptide.	J Mol Biol	2021
33781758	Community-Wide Experimental Evaluation of the PROSS Stability-Design Method.	J Mol Biol	2021
33559605	IceBear: an intuitive and versatile web application for research-data tracking from crystallization experiment to PDB deposition.	Acta Crystallogr D Struct Biol	2021
33918254	Conformation-Specific Inhibitory Anti-MMP-7 Monoclonal Antibody Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Chemotherapeutic Cell Kill.	Cancers (Basel)	2021
33085658	Correction: Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.	PLoS Comput Biol	2020
31873734	Enzyme Evolution: An Epistatic Ratchet versus a Smooth Reversible Transition.	Mol Biol Evol	2020
30478445	RASA2 and NF1; two-negative regulators of Ras with complementary functions in melanoma.	Oncogene	2019
31442220	Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.	PLoS Comput Biol	2019
31202688	The four-helix bundle in cholinesterase dimers: Structural and energetic determinants of stability.	Chem Biol Interact	2019
31444298	Pore-modulating toxins exploit inherent slow inactivation to block K<sup>+</sup> channels.	Proc Natl Acad Sci U S A	2019
29677494	Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.	Mol Cell	2018
30018322	Highly active enzymes by automated combinatorial backbone assembly and sequence design.	Nat Commun	2018
30088929	Manipulating the Folding Landscape of a Multidomain Protein.	J Phys Chem B	2018
30270109	Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.	Mol Cell	2018
30538236	Ultrahigh specificity in a network of computationally designed protein-interaction pairs.	Nat Commun	2018
29704493	Co-translational Folding Intermediate Dictates Membrane Targeting of the Signal Recognition Particle Receptor.	J Mol Biol	2018
29211984	Promiscuous Protein Binding as a Function of Protein Stability.	Structure	2017
28345864	Triple-Stage Mass Spectrometry Unravels the Heterogeneity of an Endogenous Protein Complex.	Anal Chem	2017
28973872	Principles for computational design of binding antibodies.	Proc Natl Acad Sci U S A	2017
27098554	Fine Tuning of Chlorophyll Spectra by Protein-Induced Ring Deformation.	Angew Chem Int Ed Engl	2016
27425410	Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.	Mol Cell	2016
26990888	The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex.	Protein Sci	2016
26806127	De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints.	Cell	2016
25482542	Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody.	Structure	2015
25785780	AcpM, the meromycolate extension acyl carrier protein of Mycobacterium tuberculosis, is activated by the 4'-phosphopantetheinyl transferase PptT, a potential target of the multistep mycolic acid biosynthesis.	Biochemistry	2015
23385743	Structure of ALD1, a plant-specific homologue of the universal diaminopimelate aminotransferase enzyme of lysine biosynthesis.	Acta Crystallogr Sect F Struct Biol Cryst Commun	2013
22194329	Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations.	Acta Crystallogr D Biol Crystallogr	2012
22685214	Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.	Proc Natl Acad Sci U S A	2012
21277311	Optimization of the in-silico-designed kemp eliminase KE70 by computational design and directed evolution.	J Mol Biol	2011
22198278	Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential.	Nat Med	2011
21959261	Cyt1Aa toxin: crystal structure reveals implications for its membrane-perforating function.	J Mol Biol	2011
21473635	Structure of estradiol metal chelate and estrogen receptor complex: the basis for designing a new class of selective estrogen receptor modulators.	J Med Chem	2011
21458342	A de novo protein binding pair by computational design and directed evolution.	Mol Cell	2011
20102159	Biochemical and structural properties of chimeras constructed by exchange of cofactor-binding domains in alcohol dehydrogenases from thermophilic and mesophilic microorganisms.	Biochemistry	2010
20545310	The intrinsic protein flexibility of endogenous protease inhibitor TIMP-1 controls its binding interface and affects its function.	Biochemistry	2010
20368465	Metamorphic proteins mediate evolutionary transitions of structure.	Proc Natl Acad Sci U S A	2010
20306145	Crystal structure of the three FK506 binding protein domains of wheat FKBP73: evidence for a unique wFK73_2 domain.	J Struct Funct Genomics	2010
20036254	Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the KE07 series.	J Mol Biol	2010

1 - 50 of 77

Ashwani Kumar

Bhabha Atomic Research Centre

Career Start Year 2009

Number of shared co-authors 0

Thomas Clayton

Celgene/Bristol-Myers Squibb Corporation

Career Start Year 2004

Number of shared co-authors 3

Sagar D Khare

The State University of New Jersey

Career Start Year 2003

Number of shared co-authors 8

Heath E Klock

Merck & Co., Inc.

Career Start Year 2002

Number of shared co-authors 3

Marc C Deller

Incyte Corporation

Career Start Year 2000

Number of shared co-authors 2

Anthony P Duff

Bragg Institute

Career Start Year 2000

Number of shared co-authors 1

Maksymilian Chruszcz

University of South Carolina, Michigan State University

Career Start Year 2000

Number of shared co-authors 15

David R Hall

Diamond Light Source Ltd, Harwell Science & Innovation Campus

Career Start Year 1998

Number of shared co-authors 4

Ashley M Deacon

Accelero Biostructures Inc., USA XPose Therapeutics Inc.

Career Start Year 1996

Number of shared co-authors 4

Clemens Vonrhein

Global Phasing Ltd

Career Start Year 1995

Number of shared co-authors 2

Lukasz Jaroszewski

University of California Riverside School of Medicine

Career Start Year 1995

Number of shared co-authors 10

Paul D Adams

Lawrence Berkeley National Laboratory

Career Start Year 1994

Number of shared co-authors 11

Diana R Tomchick

University of Texas Southwestern Medical Center

Career Start Year 1993

Number of shared co-authors 1

Gye Won Han

Bridge Institute, University of Southern California

Career Start Year 1991

Number of shared co-authors 6

Subbiah Parthasarathy

New York University Grossman School of Medicine

Career Start Year 1990

Number of shared co-authors 15

Wladek Minor

University of Virginia

Career Start Year 1989

Number of shared co-authors 24

Roland L Dunbrack

Fox Chase Cancer Center

Career Start Year 1989

Number of shared co-authors 9

Marc-Andr?? Elsliger

Joint Center for Structural Genomics

Career Start Year 1989

Number of shared co-authors 4

Mark S Johnson

Abo Akademi University

Career Start Year 1985

Number of shared co-authors 1

Vladimir N Malashkevich

Albert Einstein College of Medicine

Career Start Year 1982

Number of shared co-authors 9

Tom Alber

University of California berkeley

Career Start Year 1976

Number of shared co-authors 7

Ivan Rayment

College of Agricultural and Life Sciences, University of Wisconsin-Madison

Career Start Year 1976

Number of shared co-authors 1

Shoshana J Wodak

VIB-VUB Center for Structural Biology

Career Start Year 1975

Number of shared co-authors 9

Martino Bolognesi

University of Milano

Career Start Year 1975

Number of shared co-authors 4

Ezra Peisach

The State University of New Jersey

Career Start Year 1975

Number of shared co-authors 3

George N Phillips

Rice University

Career Start Year 1974

Number of shared co-authors 7

Jules Mitchell Guss

The University of Sydney

Career Start Year 1973

Number of shared co-authors 3

Tom L Blundell

Heartand Lung Research Institute, University of Cambridge

Career Start Year 1971

Number of shared co-authors 3

Wayne A Hendrickson

Columbia University

Career Start Year 1968

Number of shared co-authors 9

Robert M Stroud

University of California San Francisco

Career Start Year 1965

Number of shared co-authors 2

row(s) 1 - 30 of 30

Shira Albeck

Weizmann Institute of Science

Co-authored papers 35

Tamar Unger

Weizmann Institute of Science

Co-authored papers 19

Joel L Sussman

Weizmann Institute of Science

Co-authored papers 18

Yoav Peleg

Weizmann Institute of Science

Co-authored papers 15

Sarel J Fleishman

Co-authored papers 13

Jaime Prilusky

Weizmann Institute of Science

Co-authored papers 7

David Baker

University of Washington

Co-authored papers 5

Gideon Schreiber

Co-authored papers 5

Miriam Eisenstein

Weizmann Institute of Science

Co-authored papers 3

Gaetano T Montelione

Rensselaer Polytechnic Institute

Co-authored papers 2

Renaud Vincentelli

CNRS, Aix-Marseille Universite

Co-authored papers 2

Dana Reichmann

The A. Silberman Institute of Life Sciences, The Hebrew University of Jerusalem

Co-authored papers 2

Colin Kleanthous

Co-authored papers 2

David Eisenberg

university of california los angeles

Co-authored papers 2

David I Stuart

University of Oxford

Co-authored papers 2

Christian Cambillau

Aix Marseille University and CNRS

Co-authored papers 2

Fran??ois Guillemot

the Francis Crick Institute

Co-authored papers 1

Kristin C Gunsalus

Center for Genomics and Systems Biology, New York University Abu Dhabi (NYUAD)

Co-authored papers 1

Hualiang Jiang

Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Co-authored papers 1

Masayori Inouye

Robert Wood Johnson Medical School, Rutgers University

Co-authored papers 1

Ritu Shastry

Co-authored papers 1

Opher Gileadi

Structural Genomics Consortium Karolinska Institute Stockholm Sweden.

Co-authored papers 1

Zihe Rao

Nankai University

Co-authored papers 1

Yardena Samuels

Weizmann Institute of Science

Co-authored papers 1

Ian A Wilson

The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology

Co-authored papers 1

Kellie Cunningham

Co-authored papers 1

F W Studier

Brookhaven National Laboratory

Co-authored papers 1

Patrick Masson

carnegie mellon university

Co-authored papers 1

P??r Nordlund

Karolinska Institutet, BioClinicum J6

Co-authored papers 1

Geoffrey S Waldo

Los Alamos National Laboratory

Co-authored papers 1

1 - 30

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