Author details

Full Name

Bryan R G Williams

Affiliation

ORCID

Career Start Year

1977

Papers

351

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37001527	Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities.	Cancer Cell	2023
36875104	The protein kinase R modifies gut physiology to limit colitis.		2023
36818474	Nanocell COVID-19 vaccine triggers a novel immune response pathway producing high-affinity antibodies which neutralize all variants of concern.		2022
35692780	Integrin-Linked Kinase Expression Characterizes the Immunosuppressive Tumor Microenvironment in Colorectal Cancer and Regulates PD-L1 Expression and Immune Cell Cytotoxicity.	Frontiers in Oncology	2022
35924852	Genistein Targets STING-Driven Antiviral Responses.	mBio	2022
33674584	Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages.	Nat Commun	2021
34163519	A Potential Role for Integrin-Linked Kinase in Colorectal Cancer Growth and Progression via Regulating Senescence and Immunity.	Frontiers in Genetics	2021
31992625	Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses.	mBio	2020
31337876	Lnc(ing) interferon production and action.	Cell Research	2019
29102683	Meeting summary: 2nd Aegean Conference on Cytokine Signaling in Cancer.	Cytokine	2018
28925507	(-)-Epigallocatechin-3-gallate and EZH2 inhibitor GSK343 have similar inhibitory effects and mechanisms of action on colorectal cancer cells.	Clinical and Experimental Pharmacology and Physiology	2018
29872566	PD-L1 expression is a prognostic factor in subgroups of gastric cancer patients stratified according to their levels ofÂ CD8 and FOXP3 immune markers.	OncoImmunology	2018
29903521	Mechanisms and consequences of constitutive activation of integrin-linked kinase in acute myeloid leukemia.	Cytokine and Growth Factor Reviews	2018
27694309	Activation of cGAS-dependent antiviral responses by DNA intercalating agents.	Nucleic Acids Research	2017
28959682	An Emergence Framework of Carcinogenesis.	Frontiers in Oncology	2017
28815679	(-)-Epigallocatechin-3-gallate and atorvastatin treatment down-regulates liver fibrosis-related genes in non-alcoholic fatty liver disease.	Clinical and Experimental Pharmacology and Physiology	2017
28851763	The innate immune receptor MDA5 limits rotavirus infection but promotes cell death and pancreaticÂ inflammation.	EMBO Journal	2017
28974621	Topoisomerase 1 Inhibition Promotes Cyclic GMP-AMP Synthase-Dependent Antiviral Responses.	mBio	2017
28794235	Integrin-Linked Kinase Expression in Myeloid Cells Promotes Inflammatory Signaling during Experimental Colitis.	Journal of Immunology	2017
28611196	ATF3 Repression of BCL-X<sub>L</sub> Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types.	Clin Cancer Res	2017
29025424	Understanding immune phenotypes in human gastric disease tissues by multiplexed immunohistochemistry.	Journal of Translational Medicine	2017
29184082	Identification of a histone family gene signature for predicting the prognosis of cervical cancer patients.	Scientific Reports	2017
28281686	Auto-phosphorylation Represses Protein Kinase R Activity.	Scientific Reports	2017
28223321	A non-canonical function of Ezh2 preserves immune homeostasis.	EMBO Rep	2017
27166376	Cre-dependent DNA recombination activates a STING-dependent innate immune response.	Nucleic Acids Research	2016
27196751	Activating Transcription Factor 3 Expression as a Marker of Response to the Histone Deacetylase Inhibitor Pracinostat.	Molecular Cancer Therapeutics	2016
26794869	The kinase activity of PKR represses inflammasome activity.	Cell Research	2016
27043324	Surgical margins in head and neck squamous cell carcinoma: Effect of heat artifact on immunohistochemistry as a future tool for assessment.	Head and Neck	2016
26569329	Transcriptional Activation of Inflammatory Genes: Mechanistic Insight into Selectivity and Diversity.	Biomolecules	2015
25539920	Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors.	Nucleic Acids Research	2015
25865065	The acetyltransferase HAT1 moderates the NF-ÎºB response by regulating the transcription factor PLZF.	Nature Communications	2015
25605927	BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs.	Proc Natl Acad Sci U S A	2015
25381386	IL-10 regulates Aicda expression through miR-155.	Journal of Leukocyte Biology	2015
26518879	Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs.	Journal of Biological Chemistry	2015
26414443	The protein activator of protein kinase R, PACT/RAX, negatively regulates protein kinase R during mouse anterior pituitary development.		2015
25100717	Integrin-linked kinase modulates lipopolysaccharide- and Helicobacter pylori-induced nuclear factor ÎºB-activated tumor necrosis factor-Î± production via regulation of p65 serine 536 phosphorylation.	Journal of Biological Chemistry	2014
25404612	Molecular dynamics reveal a novel kinase-substrate interface that regulates protein translation.	Journal of Molecular Cell Biology	2014
24362029	The role of Ets2 transcription factor in the induction of microRNA-155 (miR-155) by lipopolysaccharide and its targeting by interleukin-10.	Journal of Biological Chemistry	2014
24317040	High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3.	Nature Immunology	2014
24227841	Inosine-mediated modulation of RNA sensing by Toll-like receptor 7 (TLR7) and TLR8.	Journal of Virology	2014
24905201	Protein kinase R and the inflammasome.	Journal of Interferon and Cytokine Research	2014
23697557	Activating transcription factor 3 contributes to Toll-like receptor-mediated macrophage survival via repression of Bax and Bak.	Journal of Interferon and Cytokine Research	2013
23536558	ATF3 suppresses metastasis of bladder cancer by regulating gelsolin-mediated remodeling of the actin cytoskeleton.	Cancer Research	2013
23325848	Conformational rearrangements of RIG-I receptor on formation of a multiprotein:dsRNA assembly.	Nucleic Acids Research	2013
23711406	Fine tuning type I interferon responses.	Cytokine and Growth Factor Reviews	2013
23709276	The use of miRNA microarrays for the analysis of cancer samples with global miRNA decrease.	RNA	2013
22083527	HDACi: molecular mechanisms and therapeutic implications in the innate immune system.	Immunology and Cell Biology	2012
22633459	Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense.	Immunity	2012
22684508	A miR-19 regulon that controls NF-ÎºB signaling.	Nucleic Acids Research	2012
22873641	Regulation of double-stranded RNA dependent protein kinase expression and attenuation of protein synthesis induced by bacterial toll-like receptors agonists in the absence of interferon.	Journal of Interferon and Cytokine Research	2012