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Author Details

Matthew H Todd
School of Pharmacy, University College London
2001
67
23
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36542544Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid.ACS Chem Neurosci2023
37991879Open Source Antibiotics: Simple Diarylimidazoles Are Potent against Methicillin-Resistant <i>Staphylococcus aureus</i>.ACS Infect Dis2023
37417544Structure-Property Optimization of a Series of Imidazopyridines for Visceral Leishmaniasis.ACS Infect Dis2023
37360399Target 2035 - an update on private sector contributions.RSC Med Chem2023
34212944A critical overview of computational approaches employed for COVID-19 drug discovery.Chem Soc Rev2021
33635937Copper(ii) complexes of N-propargyl cyclam ligands reveal a range of coordination modes and colours, and unexpected reactivity.Dalton Trans2021
35211674Target 2035 - update on the quest for a probe for every protein.RSC Med Chem2021
34842878Platinum binding preferences dominate the binding of novel polyamide amidine anthraquinone platinum(II) complexes to DNA.Dalton Trans2021
34250265There is no market for new antibiotics: this allows an open approach to research and development.Wellcome Open Res2021
32786609<i>tele</i>-Substitution Reactions in the Synthesis of a Promising Class of 1,2,4-Triazolo[4,3-<i>a</i>]pyrazine-Based Antimalarials.J Org Chem2020
34122912Correction: Metal complexes as a promising source for new antibiotics.Chem Sci2020
33145011Open science approaches to COVID-19.F1000Res2020
32678591Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials.J Med Chem2020
30902052The past, present and future of anti-malarial medicines.Malar J2019
31612602Six Laws of Open Source Drug Discovery.ChemMedChem2019
28981966The C6H6 NMR repository: An integral solution to control the flow of your data from the magnet to the public.Magn Reson Chem2018
30457865Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis.J Med Chem2018
30333745Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities.Front Pharmacol2018
29698504Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma.PLoS Negl Trop Dis2018
29558124Antitubercular Bis-Substituted Cyclam Derivatives: Structure-Activity Relationships and in Vivo Studies.J Med Chem2018
29052259Molecular Switches for any pH: A Systematic Study of the Versatile Coordination Behaviour of Cyclam Scorpionands.Chemistry2018
28523850N-Aryl Groups Are Ubiquitous in Cross-Dehydrogenative Couplings Because They Stabilize Reactive Intermediates.Chemistry2017
28125069Recent Advances in Macrocyclic Fluorescent Probes for Ion Sensing.Molecules2017
28419094An open source pharma roadmap.PLoS Med2017
27214150Nontoxic Metal-Cyclam Complexes, a New Class of Compounds with Potency against Drug-Resistant Mycobacterium tuberculosis.J Med Chem2016
28144313A direct method for the <i>N</i>-tetraalkylation of azamacrocycles.Beilstein J Org Chem2016
27800551Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles.ACS Cent Sci2016
27547648Synthesis and Evaluation of 1,8-Disubstituted-Cyclam/Naphthalimide Conjugates as Probes for Metal Ions.ChemistryOpen2016
25670990Efficient deprotection of F-BODIPY derivatives: removal of BF2 using Brønsted acids.Beilstein J Org Chem2015
29308130Experiences with a researcher-centric ELN.Chem Sci2015
25996061Using an open source model to accelerate schistosomiasis drug research.Future Med Chem2015
23985301Open source drug discovery - a limited tutorial.Parasitology2014
25493550Efficient Synthesis and Anti-Tubercular Activity of a Series of Spirocycles: An Exercise in Open Science.PLoS One2014
25483149The properties and performance of a pH-responsive functionalised nanoparticle.Faraday Discuss2014
25338264pH-Responsive quantum dots (RQDs) that combine a fluorescent nanoparticle with a pH-sensitive dye.Phys Chem Chem Phys2014
24983863Incorporating a piperidinyl group in the fluorophore extends the fluorescence lifetime of click-derived cyclam-naphthalimide conjugates.PLoS One2014
25132118Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid β.Metallomics2014
23303717A fluorescent "allosteric scorpionand" complex visualizes a biological recognition event.Chembiochem2013
24551546Incorporation of Bulky and Cationic Cyclam-Triazole Moieties into Marimastat Can Generate Potent MMP Inhibitory Activity without Inducing Cytotoxicity.ChemistryOpen2013
24086123Ten simple rules for cultivating open science and collaborative R&amp;D.PLoS Comput Biol2013
24219617In vitro metabolic profile and in vivo antischistosomal activity studies of (η(6)-praziquantel)Cr(CO)3 derivatives.J Med Chem2013
23820826Enhancing the usefulness of cross dehydrogenative coupling reactions with a removable protecting group.Org Biomol Chem2013
22142205Oxidative arylation of isochroman.J Org Chem2012
23094038The outcome of the oxidations of unusual enediamide motifs is governed by the stabilities of the intermediate iminium ions.PLoS One2012
21305620A click fluorophore sensor that can distinguish Cu(II) and Hg(II) via selective anion-induced demetallation.Chemistry2011
22111787Copper, nickel, and zinc cyclam-amino acid and cyclam-peptide complexes may be synthesized with "click" chemistry and are noncytotoxic.Inorg Chem2011
21941234Open science is a research accelerator.Nat Chem2011
21949890Resolution of praziquantel.PLoS Negl Trop Dis2011
21573061Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal.PLoS One2011
21380414Chemical sensors that incorporate click-derived triazoles.Chem Soc Rev2011
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Collaborators

Aled M Edwards
University of Toronto
Co-authored papers 3
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 2
Cheryl H Arrowsmith
University of Toronto
Co-authored papers 2
Stefan Knapp
Institute of Pharmaceutical Chemistry, Goethe University
Co-authored papers 2
Arti K Rai
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Co-authored papers 2
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University of California san francisco
Co-authored papers 2
Antonio Pineda-Lucena
Instituto de Investigacion Sanitaria La Fe
Co-authored papers 2
Ginger Taylor
Co-authored papers 2
Marc A Marti-Renom
Universitat Pompeu Fabra (UPF)
Co-authored papers 2
Leticia Ort??
Principe Felipe Research Center
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Narayanan Eswar
University of California at San Francisco
Co-authored papers 2
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University of Vermont Cancer Center
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Oncology R&D
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University of Georgia
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Institut fur Pharmazeutische Chemie, Philipps-Universitat Marburg
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Arij Al Chawaf
University of Toronto Toronto Ontario M5G 1L7 Canada.
Co-authored papers 1
Andrew I Su
The Scripps Research Institute
Co-authored papers 1
Stuart A Ralph
Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
Co-authored papers 1
Stephen M Fuchs
Tufts University
Co-authored papers 1
Stefan Kubicek
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Co-authored papers 1
George Papadatos
European Molecular Biology Laboratory - European Bioinformatics Institute
Co-authored papers 1
Milka Kostic
Dana-Farber Cancer Institute .
Co-authored papers 1
Tudor I Oprea
Expert Systems Inc.
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John Wilbanks
United States of America Ewing Marion Kauffman Foundation
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Paul Workman
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Timothy M Ryan
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Release 1.2