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Author Details

Natasha A Karp
Wellcome Sanger Institute
2004
90
42
PMIDPaper TitleJournal TitlePublished Year
37085139Impact of repeated micro and macro blood sampling on clinical chemistry and haematology in rats for toxicokinetic studies.Regul Toxicol Pharmacol2023
37289836Statistical simulations show that scientists need not increase overall sample size by default when including both sexes in in vivo studies.PLoS Biol2023
35179486Sex differences and sex bias in human circadian and sleep physiology research.Elife2022
35511779Do multiple experimenters improve the reproducibility of animal studies?PLoS Biol2022
36538757Correction: Do multiple experimenters improve the reproducibility of animal studies?PLoS Biol2022
36395326A qualitative study of the barriers to using blinding in in vivo experiments and suggestions for improvement.PLoS Biol2022
34855537Statistical reproducibility for pairwise <i>t</i>-tests in pharmaceutical research.Stat Methods Med Res2022
33028591Preclinical Comparison of the Blood-brain barrier Permeability of Osimertinib with Other EGFR TKIs.Clin Cancer Res2021
35047700What is the optimum design for my animal experiment?BMJ Open Sci2021
32488205Reproducibility of animal research in light of biological variation.Nat Rev Neurosci2020
34095516The ARRIVE guidelines 2.0: updated guidelines for reporting animal research.BMJ Open Sci2020
31844327High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation.Nat Immunol2020
33024165Improving reproducibility in animal research by splitting the study population into several 'mini-experiments'.Sci Rep2020
32663221Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0.PLoS Biol2020
32663219The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.PLoS Biol2020
32663096The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.J Cereb Blood Flow Metab2020
32662519The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.Br J Pharmacol2020
32660541The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.BMC Vet Res2020
32826978Reply to 'It is time for an empirically informed paradigm shift in animal research'.Nat Rev Neurosci2020
32666546The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.Exp Physiol2020
32277094A multi-batch design to deliver robust estimates of efficacy and reduce animal use - a syngeneic tumour case study.Sci Rep2020
32514108Author Correction: Reproducibility of animal research in light of biological variation.Nat Rev Neurosci2020
30640950Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection.PLoS Pathog2019
31146025The functional observational battery and modified Irwin test as global neurobehavioral assessments in the rat: Pharmacological validation data and a comparison of methods.J Pharmacol Toxicol Methods2019
30973018Feedback from the European Bioanalysis Forum liquid microsampling consortium: microsampling: assessing accuracy and precision of handheld pipettes and capillaries.Bioanalysis2019
30854487Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts.Commun Biol2019
30873526onlineFDR: an R package to control the false discovery rate for growing data repositories.Bioinformatics2019
30418665Sex bias in preclinical research and an exploration of how to change the status quo.Br J Pharmacol2019
29505576Reproducible preclinical research-Is embracing variability the answer?PLoS Biol2018
33954268Revision of the ARRIVE guidelines: rationale and scope.BMJ Open Sci2018
30254068Optimizing the design of population-based patient-derived tumor xenograft studies to better predict clinical response.Dis Model Mech2018
29614333Pharmacological validation of individual animal locomotion, temperature and behavioural analysis in group-housed rats using a novel automated home cage analysis system: A comparison with the modified Irwin test.J Pharmacol Toxicol Methods2018
29357292Reproducibility and replicability of rodent phenotyping in preclinical studies.Neurosci Biobehav Rev2018
29703891Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.Nat Commun2018
28052056Genome-wide in vivo screen identifies novel host regulators of metastatic colonization.Nature2017
28394359The role of sex and body weight on the metabolic effects of high-fat diet in C57BL/6N mice.Nutr Diabetes2017
28960183The Experimental Design Assistant.Nat Methods2017
28957312The Experimental Design Assistant.PLoS Biol2017
29026089A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.Nat Commun2017
29095442A high-throughput in vivo screening method in the mouse for identifying regulators of metastatic colonization.Nat Protoc2017
28650954Prevalence of sexual dimorphism in mammalian phenotypic traits.Nat Commun2017
28650483Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.Nat Genet2017
28830544IL-18 associated with lung lymphoid aggregates drives IFNγ production in severe COPD.Respir Res2017
28877172Automated recording of home cage activity and temperature of individual rats housed in social groups: The Rodent Big Brother project.PLoS One2017
28895944Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation.Sci Data2017
27932544Improving the Identification of Phenotypic Abnormalities and Sexual Dimorphism in Mice When Studying Rare Event Categorical Characteristics.Genetics2017
26865945Reporting phenotypes in mouse models when considering body size as a potential confounder.J Biomed Semantics2016
26387837Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines.J Pathol2016
27126290Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure.J Pathol2016
27096380Standardized Welfare Terms for the Zebrafish Community.Zebrafish2016
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Collaborators

Jacqueline K White
Wellcome Trust Sanger Institute
Co-authored papers 23
David J Adams
Wellcome Sanger Institute
Co-authored papers 18
Kathryn S Lilley
University of Cambridge
Co-authored papers 17
Terrence F Meehan
European Bioinformatics Institute
Co-authored papers 10
Ann-Marie Mallon
The Turing Institute
Co-authored papers 9
Jeremy Mason
European Molecular Biology Laboratory - European Bioinformatics Institute
Co-authored papers 9
Damian Smedley
William Harvey Research Institute, Queen Mary University of London
Co-authored papers 8
Yann Herault
Institut Clinique de la Souris (ICS), Universite de Strasbourg, CNRS, INSERM
Co-authored papers 8
Hugh Morgan
MRC Harwell Institute
Co-authored papers 8
Martin Hrab?? de Angelis
German Center for Diabetes Research (DZD e.V.)
Co-authored papers 8
Steve D M Brown
Mary Lyon Centre Harwell Science and Innovation Campus Oxfordshire UK.
Co-authored papers 8
Helen Parkinson
European Bioinformatics Institute
Co-authored papers 8
Sara Wells
Mary Lyon Centre at Medical Research Council
Co-authored papers 7
Luis Santos
The Turing Institute
Co-authored papers 7
Colin McKerlie
The Hospital for Sick Children
Co-authored papers 6
Ann M Flenniken
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 6
Simon Greenaway
Harwell Institute
Co-authored papers 5
Henrik Westerberg
MRC Harwell Institute
Co-authored papers 5
Glauco P Tocchini-Valentini
Monterotondo Mouse Clinic (MMC), Italian National Research Council (CNR)
Co-authored papers 5
Karen L Svenson
Co-authored papers 5
William C Skarnes
Wellcome Trust Sanger Institute
Co-authored papers 5
Tania Sorg
Universite de Strasbourg, CNRS, INSERM, Institut de La Clinique de La Souris
Co-authored papers 5
Kent C Lloyd
University of California davis
Co-authored papers 5
Wolfgang Wurst
Institute of Developmental Genetics, German Research Center for Environmental Health
Co-authored papers 4
Arthur L Beaudet
Baylor College of Medicine
Co-authored papers 4
Stephen A Murray
Columbia University.
Co-authored papers 4
Jonathan Warren
European Bioinformatics Institute
Co-authored papers 4
Lauryl M J Nutter
The Hospital for Sick Children
Co-authored papers 4
David B West
Children's Hospital Oakland Research Institute
Co-authored papers 4
Monica J Justice
The Hospital for Sick Children
Co-authored papers 4
Release 1.2