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Author Details

Kris M White
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
2010
45
23
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36894709Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection.Nat Genet2023
37758692Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets.Nat Commun2023
37523415Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals.PLoS Pathog2023
37738970SARS-CoV-2 variants evolve convergent strategies to remodel the host response.Cell2023
37354015Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors.Protein Sci2023
37294077Structure-Based Discovery of Inhibitors of the SARS-CoV-2 Nsp14 N7-Methyltransferase.J Med Chem2023
34669512Functional Effects of Cardiomyocyte Injury in COVID-19.J Virol2022
35766385Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity.ACS Infect Dis2022
36558898SARS-CoV-2 Inhibitors Identified by Phenotypic Analysis of a Collection of Viral RNA-Binding Molecules.Pharmaceuticals (Basel)2022
36197970Common and species-specific molecular signatures, networks, and regulators of influenza virus infection in mice, ferrets, and humans.Sci Adv2022
35012962Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19.Life Sci Alliance2022
34942634Evolution of enhanced innate immune evasion by SARS-CoV-2.Nature2022
35332335Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2.Nature2022
35169796The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters.bioRxiv2022
34112877Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19.Sci Rep2021
33495306Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A.Science2021
33791693Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2.bioRxiv2021
33821262Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19.Res Sq2021
33836156TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation.Cell2021
34663813Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.Nat Commun2021
34326236Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2.Science2021
34075384Plitidepsin has a positive therapeutic index in adult patients with COVID-19 requiring hospitalization.medRxiv2021
33984267Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture.Cell Rep2021
34260245Aryl Sulfonamide Inhibits Entry and Replication of Diverse Influenza Viruses via the Hemagglutinin Protein.J Med Chem2021
32511357A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals.bioRxiv2020
33200140Physiology of cardiomyocyte injury in COVID-19.medRxiv2020
33060197Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.Science2020
33299999Topoisomerase 1 inhibition therapy protects against SARS-CoV-2-induced inflammation and death in animal models.bioRxiv2020
33154106An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.Science2020
33097660SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling.Proc Natl Acad Sci U S A2020
32707573Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.Nature2020
32817938An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation.bioRxiv2020
32645325The Global Phosphorylation Landscape of SARS-CoV-2 Infection.Cell2020
32585083An In Vitro Microneutralization Assay for SARS-CoV-2 Serology and Drug Screening.Curr Protoc Microbiol2020
32240278Chemical intervention of influenza virus mRNA nuclear export.PLoS Pathog2020
32353859A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.Nature2020
32268088Passenger Mutations Confound Phenotypes of SARM1-Deficient Mice.Cell Rep2020
29268608Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein.ACS Infect Dis2018
30146161Transcription Elongation Can Affect Genome 3D Structure.Cell2018
29395518Influenza B virus reverse genetic backbones with improved growth properties in the EB66® cell line as basis for vaccine seed virus generation.Vaccine2018
28953980Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication.PLoS Pathog2017
25984567A Potent Anti-influenza Compound Blocks Fusion through Stabilization of the Prefusion Conformation of the Hemagglutinin Protein.ACS Infect Dis2015
23933115New-generation screening assays for the detection of anti-influenza compounds targeting viral and host functions.Antiviral Res2013
20130051Role of the IE62 consensus binding site in transactivation by the varicella-zoster virus IE62 protein.J Virol2010
20631144Varicella-zoster virus immediate-early protein 62 blocks interferon regulatory factor 3 (IRF3) phosphorylation at key serine residues: a novel mechanism of IRF3 inhibition among herpesviruses.J Virol2010
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Collaborators

Adolfo Garc??a-Sastre
Icahn School of Medicine at Mount Sinai
Co-authored papers 38
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 15
Romel Rosales
Icahn School of Medicine at Mount Sinai
Co-authored papers 15
Lisa Miorin
Icahn School of Medicine at Mount Sinai
Co-authored papers 13
Mehdi Bouhaddou
J. David Gladstone Institutes
Co-authored papers 10
Sumit K Chanda
The Scripps Research Institute
Co-authored papers 10
Kevan M Shokat
University of California San Francisco
Co-authored papers 9
Danielle L Swaney
J. David Gladstone Institutes
Co-authored papers 9
Kirsten Obernier (CM4AI)
University of California San Francisco
Co-authored papers 9
Marco Vignuzzi
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 9
Brian K Shoichet
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 8
Veronica V Rezelj
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 8
Jyoti Batra
J. David Gladstone Institutes
Co-authored papers 8
Randy A Albrecht
Icahn School of Medicine at Mount Sinai
Co-authored papers 7
Melanie Ott
Gladstone Institute of Virology
Co-authored papers 7
Margaret Soucheray
J. David Gladstone Institutes
Co-authored papers 7
Raveen Rathnasinghe
Icahn School of Medicine at Mount Sinai New York
Co-authored papers 7
Michael Schotsaert
Icahn School of Medicine at Mount Sinai
Co-authored papers 7
Laura Martin-Sancho
The Scripps Research Institute
Co-authored papers 6
Lars Pache
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 6
Pedro Beltrao
Institute of Molecular Systems Biology, ETH Zurich
Co-authored papers 6
Lorena Zuliani-Alvarez
J. David Gladstone Institutes
Co-authored papers 6
Megan L Shaw
Icahn School of Medicine at Mount Sinai
Co-authored papers 6
Thomas P Zwaka
Icahn School of Medicine at Mount Sinai
Co-authored papers 6
Hannes Braberg
University of California San Francisco
Co-authored papers 5
Kliment A Verba
University of California, University of California San Francisco
Co-authored papers 5
Soner Yildiz
University of Geneva
Co-authored papers 5
Tia A Tummino
Quantitative Biosciences Institute (QBI), University of California San Francisco
Co-authored papers 5
Danish Memon
European Bioinformatics Institute
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Paul D De Jesus
Sanford Burnham Prebys Medical Discovery Institute
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Release 1.2