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Author Details

Robert J Kay
University of Toronto
1986
48
34
PMIDPaper TitleJournal TitlePublished Year
26682987Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation.Immunity2015
21285350Phosphoinositide 3-kinase regulates plasma membrane targeting of the Ras-specific exchange factor RasGRP1.J Biol Chem2011
19168098Membrane localization of RasGRP1 is controlled by an EF-hand, and by the GEF domain.Biochim Biophys Acta2009
17523924Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs.Biochem J2007
17942889CUL7 is a novel antiapoptotic oncogene.Cancer Res2007
17567957Regulation of RasGRP1 by B cell antigen receptor requires cooperativity between three domains controlling translocation to the plasma membrane.Mol Biol Cell2007
15829980Deregulated expression of RasGRP1 initiates thymic lymphomagenesis independently of T-cell receptors.Oncogene2005
14991610The RhoA- and CDC42-specific exchange factor Dbs promotes expansion of immature thymocytes and deletion of double-positive and single-positive thymocytes.Eur J Immunol2004
14970203RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis.J Biol Chem2004
12538669Transgenic expression of RasGRP1 induces the maturation of double-negative thymocytes and enhances the production of CD8 single-positive thymocytes.J Immunol2003
11751416The chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation.Cancer Res2001
11360179The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways.Oncogene2001
10702799The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells.Oncogene2000
10951580G2A is an oncogenic G protein-coupled receptor.Oncogene2000
10523665Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation.Mol Cell Biol1999
9890991The Dbl-related protein, Lfc, localizes to microtubules and mediates the activation of Rac signaling pathways in cells.J Biol Chem1999
9819387Regulation of RasGRP via a phorbol ester-responsive C1 domain.Mol Cell Biol1998
9657155Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation.Cell1998
9844916Dissection of signaling pathways and cloning of new signal transducers in tyrosine kinase-induced pathways by genetic selection.Leukemia1998
9372970Complementation of growth factor receptor-dependent mitogenic signaling by a truncated type I phosphatidylinositol 4-phosphate 5-kinase.Mol Cell Biol1997
8543797Reduction of early B lymphocyte precursors in transgenic mice overexpressing the murine heat-stable antigen.J Immunol1996
8920854Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes.J Exp Med1996
8910315Lfc and Lsc oncoproteins represent two new guanine nucleotide exchange factors for the Rho GTP-binding protein.J Biol Chem1996
8702517Expression cloning of lsc, a novel oncogene with structural similarities to the Dbl family of guanine nucleotide exchange factors.J Biol Chem1996
7654214Functions of the C-terminal domain of CTP: phosphocholine cytidylyltransferase. Effects of C-terminal deletions on enzyme activity, intracellular localization and phosphorylation potential.Biochem J1995
7823939Expression cloning of oncogenes by retroviral transfer of cDNA libraries.Mol Cell Biol1995
7862449Retroviral transduction and oncogenic selection of a cDNA encoding Dbs, a homolog of the Dbl guanine nucleotide exchange factor.Oncogene1995
7629163Expression cloning of lfc, a novel oncogene with structural similarities to guanine nucleotide exchange factors and to the regulatory region of protein kinase C.J Biol Chem1995
7918629Primary structure and expression of a human CTP:phosphocholine cytidylyltransferase.Biochim Biophys Acta1994
8270863Defective development of thymocytes overexpressing the costimulatory molecule, heat-stable antigen.J Exp Med1994
7959762Mapping of CD24 and homologous sequences to multiple chromosomal loci.Genomics1994
7949162Selection of retrovirally transduced hematopoietic cells using CD24 as a marker of gene transfer.Blood1994
7683034Expression of Thy-1 on human hematopoietic progenitor cells.J Exp Med1993
1332057Ligand-induced phosphorylation of the murine interleukin 3 receptor signals its cleavage.Proc Natl Acad Sci U S A1992
1644833Purification of the murine interleukin 3 receptor.J Biol Chem1992
1712638Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer.Blood1991
1831224CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor.J Immunol1991
2118158Expression cloning of a cDNA encoding M1/69-J11d heat-stable antigens.J Immunol1990
2318876Heterogeneous modifications of the 114/A10 protein of interleukin-3-dependent cells are concentrated in a highly repetitive amino-terminal domain.J Biol Chem1990
2166941Cloning and expression of rat liver CTP: phosphocholine cytidylyltransferase: an amphipathic protein that controls phosphatidylcholine synthesis.Proc Natl Acad Sci U S A1990
2632349Structure, organization, and expression of the 16-kDa heat shock gene family of Caenorhabditis elegans.Genome1989
2784793Molecular cloning of 114/A10, a cell surface antigen containing highly conserved repeated elements, which is expressed by murine hemopoietic progenitor cells and interleukin-3-dependent cell lines.J Biol Chem1989
2788579Identification and characterization of 114/A10, an antigen highly expressed on the surface of murine myeloid and erythroid progenitor cells and IL-3-dependent cell lines.Exp Hematol1989
3031611Hybrid pUC vectors for addition of new restriction enzyme sites to the ends of DNA fragments.Nucleic Acids Res1987
17770331Duplication of CaMV 35S Promoter Sequences Creates a Strong Enhancer for Plant Genes.Science1987
3588308Expression of intron-containing C. elegans heat shock genes in mouse cells demonstrates divergence of 3' splice site recognition sequences between nematodes and vertebrates, and an inhibitory effect of heat shock on the mammalian splicing apparatus.Nucleic Acids Res1987
3017958Structure, expression, and evolution of a heat shock gene locus in Caenorhabditis elegans that is flanked by repetitive elements.J Biol Chem1986
3023964Efficient transcription of a Caenorhabditis elegans heat shock gene pair in mouse fibroblasts is dependent on multiple promoter elements which can function bidirectionally.Mol Cell Biol1986
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Collaborators

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Lunenfeld-Tanenbaum Research Institute
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Wellcome Sanger Institute
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Universite de Montreal
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University of Toronto
Co-authored papers 1
3Allergan Inc.,Markham,Ontario,Canada.
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University of California los angeles
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The Hospital for Sick Children, University of Toronto
Co-authored papers 1
University of California los angeles
Co-authored papers 1
Children's Hospital Research Foundation
Co-authored papers 1
University of Toronto, College St
Co-authored papers 1
Schroeder Arthritis Institute
Co-authored papers 1
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The Ontario Cancer Institute, Princess Margaret Hospital, University of Toronto
Co-authored papers 1
University of California los angeles
Co-authored papers 1
the Princess Margaret Cancer Centre, University Health Network
Co-authored papers 1
Institute for Research in Immunology and Cancer (IRIC), University of Montreal
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University of Toronto
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